Click here to switch to the map view.

The map label for this gene is ribBA [H]

Identifier: 17231028

GI number: 17231028

Start: 4259678

End: 4261441

Strand: Reverse

Name: ribBA [H]

Synonym: all3536

Alternate gene names: 17231028

Gene position: 4261441-4259678 (Counterclockwise)

Preceding gene: 17231030

Following gene: 17231026

Centisome position: 66.44

GC content: 44.44

Gene sequence:

>1764_bases
GTGTCACAACCTAAAAATACACAGCAGTCCTCAACTAATCCCCTGAACGGGGAGAACCCTGGCACGGGTGTTGTTCCTCA
GATATTTGCCTCTTCAACCGAAAAGTTTATGTTTGATTCTATTGATGCTGCCTTATCAGATTTAAAAGCCGGTCGTGCCA
TTGTAGTGGTAGATGATGAAAATCGAGAAAATGAAGGCGATTTGATTTGTGCTGCCCAATTTGCCACACCTGACATGATT
AATTTTATGGCGGTGGAAGCAAGAGGGTTGATTTGTTTAGCAATGACAGGCGATCGCCTCGATGAACTCGATCTACCATT
GATGGTGACAAATATCACCGACCCCAACCAGACAGCTTTTACTGTCAGTATTGATGCTAGCCCCCATTTGGGAGTATCTA
CTGGTATATCAGCCGAAGACCGGGCGCGAACAATTCAGATTACACTCAACCCAGCCACCAAACCTTCAGATTTGCGTCGT
CCTGGTCATATTTTTCCTTTACGGGCTAAAGCTGGCGGAGTACTGAAACGCGCAGGGCATACAGAGGCGGCGGTTGATTT
ATCTCGCTTGGCTGGATTGTACCCGGCTGGGGTGATTTGTGAAATTCAAAACCCCGATGGTTCAATGGCGAGATTACAAC
AGTTAATTGAATATGCCAAACACCACAACCTGAAAATTATTAGTATTGCTGATTTAATTAGTTATCGCCTGCAACACGAT
CGCCTGGTATATCGTGAAGTAGTCACTAAACTACCCAGTCAATTCGGTCAGTTTGACATCTACGCCTATCGCCACACCCT
CGACAATACAGAACACGTCGCCATTGTCAAGGGCAATCCTGAGAACTTTCGAGATGAACCTGTGATGGTGCGGATGCACT
CAGAATGTTTAACAGGTGATGCGTTGGGTTCTTTACGCTGCGATTGTCGGATGCAGTTACAAGCTGCCTTGAAAATGATT
GAAACTGCTGGTCAAGGTGTGGTTGTCTACCTAAGGCAAGAAGGACGAGGAATTGGCTTAATTAACAAACTTAAAGCCTA
TTCTTTACAGGATATGGGACTGGATACAGTGGAAGCTAACGAGCGCTTGGGTTTCCCCGCAGACTTGCGTGATTATGGCA
TGGGAGCGCAAATGCTTATGGATTTGGGCGTGAAAAAGATTCGCCTGATTACTAATAATCCCCGGAAAATTGCCGGGGTA
AAAGGGTATGGGTTGGAAGTAGTTGACCGCCTGCCATTACTCATTGAAGCCAACGATTATAATTCCTATTACTTGGCGAC
CAAGGCGAAAAAACTCGGTCATATGCTTTTGCAGACTTACCTCGTAACTGTAGCTATTCACTGGCAAGATGACCCGCAAT
TGGTGACAAAACGCTATGAACGTTTAGAGAAACTGCGGCATTTAGTTAGAGGCTATGATTTATTGTTACAGGAAGAAGCC
CGACCATTGGCGATCGCTCTTTTCGACAAGCCATCTTTGACAGTACACTTAGGGTTTGACCAAGAAAAAGTCGCTAGTTG
TGATTGGTATAGCCAAAGCGGTCATCCCTACGTACAAGCAATTTTGCCAATTCTCGATAACCTAGCAACTCTACCTTACG
TCCAGAAACTTGAATTTTTGATTTCTCCTGGTAGTGATCCCCTCAGTAATTTGCAAGTCCAACTAGACAGGCAAACGATT
TCACCTGATAAATTACCTTCTTCTGTAAGTAATGAGTTGGAGACACAGAAAATTTACAGTTTGAGTAAAGAATTGGAAGA
TTGA

Upstream 100 bases:

>100_bases
ATCAAAACATTGCTAGTCTATATCTCCGCCGTATAAACGAGCTACAATTTAGAATAAGAAATTGTTAAGAAAATTTACTA
TCCCTGGCTCAAAATCCTCT

Downstream 100 bases:

>100_bases
ATCAATTCAAAATTCAAAATTCAAAATAGCCTACGGCTACTCCTGCGGATAACTCGCAGAGTAGGCTACGCCAACAAAAT
ACCCTTCTCCTTTGGAGATG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MSQPKNTQQSSTNPLNGENPGTGVVPQIFASSTEKFMFDSIDAALSDLKAGRAIVVVDDENRENEGDLICAAQFATPDMI
NFMAVEARGLICLAMTGDRLDELDLPLMVTNITDPNQTAFTVSIDASPHLGVSTGISAEDRARTIQITLNPATKPSDLRR
PGHIFPLRAKAGGVLKRAGHTEAAVDLSRLAGLYPAGVICEIQNPDGSMARLQQLIEYAKHHNLKIISIADLISYRLQHD
RLVYREVVTKLPSQFGQFDIYAYRHTLDNTEHVAIVKGNPENFRDEPVMVRMHSECLTGDALGSLRCDCRMQLQAALKMI
ETAGQGVVVYLRQEGRGIGLINKLKAYSLQDMGLDTVEANERLGFPADLRDYGMGAQMLMDLGVKKIRLITNNPRKIAGV
KGYGLEVVDRLPLLIEANDYNSYYLATKAKKLGHMLLQTYLVTVAIHWQDDPQLVTKRYERLEKLRHLVRGYDLLLQEEA
RPLAIALFDKPSLTVHLGFDQEKVASCDWYSQSGHPYVQAILPILDNLATLPYVQKLEFLISPGSDPLSNLQVQLDRQTI
SPDKLPSSVSNELETQKIYSLSKELED

Sequences:

>Translated_587_residues
MSQPKNTQQSSTNPLNGENPGTGVVPQIFASSTEKFMFDSIDAALSDLKAGRAIVVVDDENRENEGDLICAAQFATPDMI
NFMAVEARGLICLAMTGDRLDELDLPLMVTNITDPNQTAFTVSIDASPHLGVSTGISAEDRARTIQITLNPATKPSDLRR
PGHIFPLRAKAGGVLKRAGHTEAAVDLSRLAGLYPAGVICEIQNPDGSMARLQQLIEYAKHHNLKIISIADLISYRLQHD
RLVYREVVTKLPSQFGQFDIYAYRHTLDNTEHVAIVKGNPENFRDEPVMVRMHSECLTGDALGSLRCDCRMQLQAALKMI
ETAGQGVVVYLRQEGRGIGLINKLKAYSLQDMGLDTVEANERLGFPADLRDYGMGAQMLMDLGVKKIRLITNNPRKIAGV
KGYGLEVVDRLPLLIEANDYNSYYLATKAKKLGHMLLQTYLVTVAIHWQDDPQLVTKRYERLEKLRHLVRGYDLLLQEEA
RPLAIALFDKPSLTVHLGFDQEKVASCDWYSQSGHPYVQAILPILDNLATLPYVQKLEFLISPGSDPLSNLQVQLDRQTI
SPDKLPSSVSNELETQKIYSLSKELED
>Mature_586_residues
SQPKNTQQSSTNPLNGENPGTGVVPQIFASSTEKFMFDSIDAALSDLKAGRAIVVVDDENRENEGDLICAAQFATPDMIN
FMAVEARGLICLAMTGDRLDELDLPLMVTNITDPNQTAFTVSIDASPHLGVSTGISAEDRARTIQITLNPATKPSDLRRP
GHIFPLRAKAGGVLKRAGHTEAAVDLSRLAGLYPAGVICEIQNPDGSMARLQQLIEYAKHHNLKIISIADLISYRLQHDR
LVYREVVTKLPSQFGQFDIYAYRHTLDNTEHVAIVKGNPENFRDEPVMVRMHSECLTGDALGSLRCDCRMQLQAALKMIE
TAGQGVVVYLRQEGRGIGLINKLKAYSLQDMGLDTVEANERLGFPADLRDYGMGAQMLMDLGVKKIRLITNNPRKIAGVK
GYGLEVVDRLPLLIEANDYNSYYLATKAKKLGHMLLQTYLVTVAIHWQDDPQLVTKRYERLEKLRHLVRGYDLLLQEEAR
PLAIALFDKPSLTVHLGFDQEKVASCDWYSQSGHPYVQAILPILDNLATLPYVQKLEFLISPGSDPLSNLQVQLDRQTIS
PDKLPSSVSNELETQKIYSLSKELED

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=50, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=50, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=42.9951690821256, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=43.9306358381503, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 65179; Mature: 65047

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPKNTQQSSTNPLNGENPGTGVVPQIFASSTEKFMFDSIDAALSDLKAGRAIVVVDDE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
NRENEGDLICAAQFATPDMINFMAVEARGLICLAMTGDRLDELDLPLMVTNITDPNQTAF
CCCCCCCEEEEEECCCCCHHHEEEEECCCEEEEEECCCCCCCCCCCEEEEECCCCCCEEE
TVSIDASPHLGVSTGISAEDRARTIQITLNPATKPSDLRRPGHIFPLRAKAGGVLKRAGH
EEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCCCCEEEEECCCCCHHHHCCC
TEAAVDLSRLAGLYPAGVICEIQNPDGSMARLQQLIEYAKHHNLKIISIADLISYRLQHD
CHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
RLVYREVVTKLPSQFGQFDIYAYRHTLDNTEHVAIVKGNPENFRDEPVMVRMHSECLTGD
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEEEEECHHCCCC
ALGSLRCDCRMQLQAALKMIETAGQGVVVYLRQEGRGIGLINKLKAYSLQDMGLDTVEAN
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCHHHCCCCEECCC
ERLGFPADLRDYGMGAQMLMDLGVKKIRLITNNPRKIAGVKGYGLEVVDRLPLLIEANDY
CCCCCCCCHHHHCCCHHHHHHCCCEEEEEEECCCCEEECCCCCCHHHHCCCCEEEEECCC
NSYYLATKAKKLGHMLLQTYLVTVAIHWQDDPQLVTKRYERLEKLRHLVRGYDLLLQEEA
CCEEEEHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLAIALFDKPSLTVHLGFDQEKVASCDWYSQSGHPYVQAILPILDNLATLPYVQKLEFL
CCEEEEEECCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHE
ISPGSDPLSNLQVQLDRQTISPDKLPSSVSNELETQKIYSLSKELED
ECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQPKNTQQSSTNPLNGENPGTGVVPQIFASSTEKFMFDSIDAALSDLKAGRAIVVVDDE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
NRENEGDLICAAQFATPDMINFMAVEARGLICLAMTGDRLDELDLPLMVTNITDPNQTAF
CCCCCCCEEEEEECCCCCHHHEEEEECCCEEEEEECCCCCCCCCCCEEEEECCCCCCEEE
TVSIDASPHLGVSTGISAEDRARTIQITLNPATKPSDLRRPGHIFPLRAKAGGVLKRAGH
EEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCCCCEEEEECCCCCHHHHCCC
TEAAVDLSRLAGLYPAGVICEIQNPDGSMARLQQLIEYAKHHNLKIISIADLISYRLQHD
CHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
RLVYREVVTKLPSQFGQFDIYAYRHTLDNTEHVAIVKGNPENFRDEPVMVRMHSECLTGD
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEEEEECHHCCCC
ALGSLRCDCRMQLQAALKMIETAGQGVVVYLRQEGRGIGLINKLKAYSLQDMGLDTVEAN
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCHHHCCCCEECCC
ERLGFPADLRDYGMGAQMLMDLGVKKIRLITNNPRKIAGVKGYGLEVVDRLPLLIEANDY
CCCCCCCCHHHHCCCHHHHHHCCCEEEEEEECCCCEEECCCCCCHHHHCCCCEEEEECCC
NSYYLATKAKKLGHMLLQTYLVTVAIHWQDDPQLVTKRYERLEKLRHLVRGYDLLLQEEA
CCEEEEHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLAIALFDKPSLTVHLGFDQEKVASCDWYSQSGHPYVQAILPILDNLATLPYVQKLEFL
CCEEEEEECCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHE
ISPGSDPLSNLQVQLDRQTISPDKLPSSVSNELETQKIYSLSKELED
ECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]