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The map label for this gene is purD

Identifier: 17231002

GI number: 17231002

Start: 4230076

End: 4231353

Strand: Direct

Name: purD

Synonym: alr3510

Alternate gene names: 17231002

Gene position: 4230076-4231353 (Clockwise)

Preceding gene: 17231000

Following gene: 17231003

Centisome position: 65.95

GC content: 49.14

Gene sequence:

>1278_bases
GTGAAAGTTTTAGTTGTCGGTAACGGGGGACGTGAACACGCTCTAGCGTGGAAACTATTGCAATCGCCACAAATTGAGCA
AGTCGCCTGTGTGCCAGGAAATGGGGGGACGGCAACTTTGGCACGTTGCCAAAATGTATCTTTAGCCGTGGATGATTTTG
AGGGAATTAGTCAATATGCCTTGAATCAGGGTTTTTCTTTGGTGGTAGTCGGGCCGGAAGTACCCTTGGCAAAAGGAATT
ACTGACTATCTACAAGAAAAAGGGTTGATGGTGTTTGGGCCAAGCCGAGCCGGAGCGCAAATTGAAGCGAGTAAGGCTTG
GGCAAAAGCTCTGATGCAGGAAGCTGGGATTCCTACCGCCAAGGCTGCGGTATTTACAGAGGCAGCAGCAGCCAAGTCAT
ATATTCAGGCACAGGGAGCGCCTATAGTCGTCAAGGCGGATGGTTTAGCGGCTGGCAAGGGTGTCACCGTGGCAACGACA
ATTGAACAGGCACAGAGTGCCATTGATGCCATATTTCAAGGGCAGTTTGGTAGTGCGGGTGAGTTTGTTGTCATTGAAGA
ATGTTTGACTGGGCAAGAAGTTTCTGTATTGGCTTTGACGGATGGATTGACAATTCGTCCCTTGTTACCCGCCCAAGACC
ATAAGCGAATTGGGGAAGGGGATACAGGGGAAAATACAGGCGGGATGGGAGCTTATGCACCAGCACCAATCGCCACACCA
GAGTTAATGGCACTGGTGCAAACCGAAGTTTTAGAAAGAGCGATCGCCACCTTACAATCTAAAGGCATCGATTATCGTGG
TGTACTCTACGCCGGGTTGATGATTACACCCAATGGCGATTTTAAGGTCTTAGAATTTAACTGCCGCTTTGGCGACCCAG
AAACGCAAGTCATCCTCCCCTTATTAGCCACCCCCCTAGAAGAATTGATTCTAGCTTGTGTACAGCAGCGTTTAGGTGAG
CTACCACCCATTGCTTGGCAAGGGGGAGCATCCGCCACCGTAGTGGCAGCTTCCGGCGGCTATCCTGGGGATTATGAAAA
AGGCCAAGTCATTACCGGCATTCCTCAAGCAGAAGCCACAGGTGCAACAGTATTTCATGCAGGCACAAAGTTGAACGCGC
AACAACAGATAGTTACAGATGGCGGCAGAGTCCTAAATGTTACAGGAATCGGAGAAAATTTCCAACAAGCCCTCGCGCAA
GCGTACACTGGAATTAAAGCCATAGACTTTTCGGGCATATATTACCGGAGAGATATTGGTTATAGAGTCAATAGTTGA

Upstream 100 bases:

>100_bases
TCCCCATCATAGGACTTGCATCAAGGTCAGAATTGGTGAAGAATTGATCCGCGAGAGTCATAAAGTACTCTCGCTTCGCC
AGAGACGCAAGAGGGAATCA

Downstream 100 bases:

>100_bases
TAGTCCGAAGTCCATTGTTAACTGTTGACCGTTGACCGTTGACTAATAACAACTGACAACTGACAACTGAGCTAATGTCC
AAAATAACTGTTAATTTTTA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYALNQGFSLVVVGPEVPLAKGI
TDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTAKAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATT
IEQAQSAIDAIFQGQFGSAGEFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATP
ELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILPLLATPLEELILACVQQRLGE
LPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEATGATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQ
AYTGIKAIDFSGIYYRRDIGYRVNS

Sequences:

>Translated_425_residues
MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYALNQGFSLVVVGPEVPLAKGI
TDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTAKAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATT
IEQAQSAIDAIFQGQFGSAGEFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATP
ELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILPLLATPLEELILACVQQRLGE
LPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEATGATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQ
AYTGIKAIDFSGIYYRRDIGYRVNS
>Mature_425_residues
MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYALNQGFSLVVVGPEVPLAKGI
TDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTAKAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATT
IEQAQSAIDAIFQGQFGSAGEFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATP
ELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILPLLATPLEELILACVQQRLGE
LPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEATGATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQ
AYTGIKAIDFSGIYYRRDIGYRVNS

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI4503915, Length=423, Percent_Identity=50.8274231678487, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI209869995, Length=423, Percent_Identity=50.8274231678487, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI209869993, Length=423, Percent_Identity=50.8274231678487, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI28416899, Length=423, Percent_Identity=50.8274231678487, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1790438, Length=423, Percent_Identity=48.6997635933806, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567511, Length=429, Percent_Identity=42.4242424242424, Blast_Score=323, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6321203, Length=437, Percent_Identity=42.79176201373, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI24582400, Length=429, Percent_Identity=49.4172494172494, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI62471619, Length=429, Percent_Identity=49.4172494172494, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PUR2_NOSS1 (Q8YRD8)

Other databases:

- EMBL:   BA000019
- PIR:   AG2244
- RefSeq:   NP_487550.1
- ProteinModelPortal:   Q8YRD8
- SMR:   Q8YRD8
- STRING:   Q8YRD8
- GeneID:   1107108
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3510
- NMPDR:   fig|103690.1.peg.3817
- eggNOG:   COG0151
- HOGENOM:   HBG404060
- OMA:   GVPIVIK
- PhylomeDB:   Q8YRD8
- ProtClustDB:   PRK00885
- BioCyc:   NSP103690:ALR3510-MONOMER
- HAMAP:   MF_00138
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.90.600.10
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR00877

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.13

Molecular weight: Translated: 44390; Mature: 44390

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50975 ATP_GRASP; PS00184 GARS; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYA
CEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCEEEECCHHHHHHHH
LNQGFSLVVVGPEVPLAKGITDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTA
HCCCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCEEEHHHHHHHHHHHHCCCCHH
KAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATTIEQAQSAIDAIFQGQFGSAG
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCC
EFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATP
CEEEEEHHCCCCCEEEEEEECCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILP
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCEEEHH
LLATPLEELILACVQQRLGELPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEAT
HHHCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCC
GATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQAYTGIKAIDFSGIYYRRDIG
CCEEEECCCCCCCCCEEECCCCEEEEEEECCHHHHHHHHHHHCCCEEEECCCEEEEEECC
YRVNS
EEECC
>Mature Secondary Structure
MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYA
CEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCEEEECCHHHHHHHH
LNQGFSLVVVGPEVPLAKGITDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTA
HCCCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCEEEHHHHHHHHHHHHCCCCHH
KAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATTIEQAQSAIDAIFQGQFGSAG
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCC
EFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATP
CEEEEEHHCCCCCEEEEEEECCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILP
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCEEEHH
LLATPLEELILACVQQRLGELPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEAT
HHHCCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCC
GATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQAYTGIKAIDFSGIYYRRDIG
CCEEEECCCCCCCCCEEECCCCEEEEEEECCHHHHHHHHHHHCCCEEEECCCEEEEEECC
YRVNS
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840