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The map label for this gene is tynA [C]

Identifier: 17230923

GI number: 17230923

Start: 4137723

End: 4139705

Strand: Direct

Name: tynA [C]

Synonym: alr3431

Alternate gene names: 17230923

Gene position: 4137723-4139705 (Clockwise)

Preceding gene: 17230922

Following gene: 17230926

Centisome position: 64.51

GC content: 42.56

Gene sequence:

>1983_bases
ATGATAAAGCGGCTAAAGCTATTCTTCTTGTTAGCTATTACTATTATTATCTGCTGTGGTATATCACTTATATTAATAGA
AACAGTGACAGCAAAACAGCCAGTAATTTCCCATCCTTTGACAGCTTTAACCGAGGCAGAAATTAAAACGGCGGTTGCCT
TGATTAGAAAGGAAAAGTCTTTAACTGACATGGCTGCTTTTCCGTTAATTACCTTGGCTGAACCAGATAAACAAGAAGTT
AGAAATTTTACACAAGGTCAATCATTTGAGCGCAAGGCTTTTTTGGTAGTATATGAGCGCGCGCAAAATAAAACCTATGA
GGGTATTGTTGACCTGAAAACGCAAAAAATAGCGTCCTGGCAAGAGAAACCCCATGTGCAACCGGCAATTTTTAACTCAG
AATATGAACTAGCACGCAATGTAGTCAAATCTGATTCCCGATGGCAAGAAGCGATGAAAAAGCGGGGAATTACAGATTTT
GACCAAGTGCAGGTGAGTTGCTGGGCGGCGGGCATTCTAAGTCAAGAAGAAGCAGCAACAGGGGGGCGTTTGTGTCGGAC
TTTATTATTTTATCGCGGGGAACGCTGGAATTATTACGGTAGTCCTATTGAGGGTGTGATAGCAACGGTTGATTTAAATA
AAGGTACAGTCACCAATTTTATCGACCAGGGGATAGTTCCCATCTCCAAAGAAAATTGGAATTATGATTTACAGTCTTTA
GGTAAATTACTCTCACCGCCGAAACTCTTACAAATACTGCAACCAAAAGGAAAGAGTTTCCAAATTCAGGGTAATGAAGT
CACCTGGCAAGGTTGGAAGTTTCGGTATGTTATGCACCCCCGTGATGGGTTGGTACTGTATCAAGTAAATTACAAAGATG
GGGGAAATGTCCGACCAGTATTGTATCGCGCCAGCTTATCGGAGATGGTTGTACCTTATGGCGACCCTGATCCTACTTGG
TCATTTAGAAACGCTTTCGATGTTGGTGAATATAATCTGGGTTTACTCGCCAGCACAATGGAGTTAGGAAAGGAAATTCC
CCAAAATGGCGTTTTATTTGATGCTGTGTTTGCTAATGAAGAAGGGGAACCCTATGTTATGCCTGGGGTTGTGGGTATCT
ACGAACGGGATAACGGCATACTTTGGAAGCATTATGAATATAATACCCAACGCAACGATGTGCGGCGCGATCGCCAATTA
GTCATTACCATCACGGCGGCGGTTGATAACTATGATTACGGTATTAACTGGATTTTCCACCAAGACGGCACGTTAGAAGT
AGAGAATGATTTAACCGGTATTGTTTTGGTGCAGGGAACAGAAGCGGAAACCCAACCTGAAGATAATTTCTATGGGAGAT
TGCTGGCTAAAAATATTTTTGGTGTCAATCACCAACACTTTTTTAACTATCGCTTAGATATGGATGTGGACGGTCAAGCT
AATAATGTCATGGAAATGAACGTGGCAAGCTTGCCGATAGGTAAGAACAATCCTATCGGCAATGCCATTGTTGTCAAAGA
CACCCCACTCAAAACAGAAAAGGCTGCTGTCCGTGATTTGGATATCAAACACAGTCGGGAATGGATGATTGCGAATGCAG
ATAAGAAAAATGCTTTAGGGGTTGCCCCTGCATATATGCTGATGCCGGGAGGTAATACGGTATTTTTCCCTGTGGAGGGG
GCAAAAATTCGGCAGAAAGCTGAGTTTGCCACTCATCATGTTTGGGTGACTCGATATAAACCACATGAATTATATGCCGG
CGGTGATTATCCTAATCAAGCACCACCAGGAAAAGGTTTACCTGAGTATATTGCTGATGATGAATCGTTGATGGGTCAAG
ATATTGTTTTGTGGTACACGATGGGTATTACTCATGTACCTAAGCCAGAAGATTGGCCTGTGATGCCGGTTCACAAGCTT
GGCTTTAAACTTTCACCTAGAGGCTTTTTTAGCCGCAATCCGGCGATTAATCTGCCTGAGTAA

Upstream 100 bases:

>100_bases
CCCGATTTCTCAAAAAAGTCGGGTATCTGTCTTAACTATTCGGTTTTATATCTGAATTCTGGGAAATAAATAACTATAAA
TTTATTGCCAGATTCCTAGA

Downstream 100 bases:

>100_bases
GTTGTTGCAGCAATTGTATTCATCAATCGCGATCGCCTACAGTGGGTCTATGCCCTGCCGTGGGTGATATATTAGGCTGA
GATTAAAGCTTTAACTTGAC

Product: tyramine oxidase

Products: NA

Alternate protein names: Copper amine oxidase [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MIKRLKLFFLLAITIIICCGISLILIETVTAKQPVISHPLTALTEAEIKTAVALIRKEKSLTDMAAFPLITLAEPDKQEV
RNFTQGQSFERKAFLVVYERAQNKTYEGIVDLKTQKIASWQEKPHVQPAIFNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAATGGRLCRTLLFYRGERWNYYGSPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLQSL
GKLLSPPKLLQILQPKGKSFQIQGNEVTWQGWKFRYVMHPRDGLVLYQVNYKDGGNVRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLFDAVFANEEGEPYVMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQPEDNFYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVASLPIGKNNPIGNAIVVKDTPLKTEKAAVRDLDIKHSREWMIANADKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTRYKPHELYAGGDYPNQAPPGKGLPEYIADDESLMGQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRGFFSRNPAINLPE

Sequences:

>Translated_660_residues
MIKRLKLFFLLAITIIICCGISLILIETVTAKQPVISHPLTALTEAEIKTAVALIRKEKSLTDMAAFPLITLAEPDKQEV
RNFTQGQSFERKAFLVVYERAQNKTYEGIVDLKTQKIASWQEKPHVQPAIFNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAATGGRLCRTLLFYRGERWNYYGSPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLQSL
GKLLSPPKLLQILQPKGKSFQIQGNEVTWQGWKFRYVMHPRDGLVLYQVNYKDGGNVRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLFDAVFANEEGEPYVMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQPEDNFYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVASLPIGKNNPIGNAIVVKDTPLKTEKAAVRDLDIKHSREWMIANADKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTRYKPHELYAGGDYPNQAPPGKGLPEYIADDESLMGQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRGFFSRNPAINLPE
>Mature_660_residues
MIKRLKLFFLLAITIIICCGISLILIETVTAKQPVISHPLTALTEAEIKTAVALIRKEKSLTDMAAFPLITLAEPDKQEV
RNFTQGQSFERKAFLVVYERAQNKTYEGIVDLKTQKIASWQEKPHVQPAIFNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAATGGRLCRTLLFYRGERWNYYGSPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLQSL
GKLLSPPKLLQILQPKGKSFQIQGNEVTWQGWKFRYVMHPRDGLVLYQVNYKDGGNVRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLFDAVFANEEGEPYVMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQPEDNFYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVASLPIGKNNPIGNAIVVKDTPLKTEKAAVRDLDIKHSREWMIANADKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTRYKPHELYAGGDYPNQAPPGKGLPEYIADDESLMGQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRGFFSRNPAINLPE

Specific function: Oxidizes histamine. Other amines including phenethylamine, tyramine, tryptamine, putrescine, and benzylamine also serve as substrate [H]

COG id: COG3733

COG function: function code Q; Cu2+-containing amine oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the copper/topaquinone oxidase family [H]

Homologues:

Organism=Homo sapiens, GI73486661, Length=423, Percent_Identity=26.241134751773, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI60498984, Length=452, Percent_Identity=25.4424778761062, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI60498982, Length=450, Percent_Identity=24.6666666666667, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4502119, Length=418, Percent_Identity=22.0095693779904, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1787651, Length=634, Percent_Identity=32.6498422712934, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000269
- InterPro:   IPR015798
- InterPro:   IPR016182
- InterPro:   IPR015800
- InterPro:   IPR015801
- InterPro:   IPR015802 [H]

Pfam domain/function: PF01179 Cu_amine_oxid; PF02727 Cu_amine_oxidN2; PF02728 Cu_amine_oxidN3 [H]

EC number: =1.4.3.22 [H]

Molecular weight: Translated: 74641; Mature: 74641

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS01165 COPPER_AMINE_OXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRLKLFFLLAITIIICCGISLILIETVTAKQPVISHPLTALTEAEIKTAVALIRKEKS
CCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCC
LTDMAAFPLITLAEPDKQEVRNFTQGQSFERKAFLVVYERAQNKTYEGIVDLKTQKIASW
HHHHHHCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHH
QEKPHVQPAIFNSEYELARNVVKSDSRWQEAMKKRGITDFDQVQVSCWAAGILSQEEAAT
HHCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHEEEEHHHHHCCCHHHCC
GGRLCRTLLFYRGERWNYYGSPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLQSL
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCCCCHHHH
GKLLSPPKLLQILQPKGKSFQIQGNEVTWQGWKFRYVMHPRDGLVLYQVNYKDGGNVRPV
HHHCCCHHHHHHHCCCCCEEEEECCEEEECCEEEEEEECCCCCEEEEEEECCCCCCCCEE
LYRASLSEMVVPYGDPDPTWSFRNAFDVGEYNLGLLASTMELGKEIPQNGVLFDAVFANE
EEECCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
EGEPYVMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQLVITITAAVDNYDYGINWIFH
CCCCEECCCEEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCEEEEEE
QDGTLEVENDLTGIVLVQGTEAETQPEDNFYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
CCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
NNVMEMNVASLPIGKNNPIGNAIVVKDTPLKTEKAAVRDLDIKHSREWMIANADKKNALG
CCEEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCC
VAPAYMLMPGGNTVFFPVEGAKIRQKAEFATHHVWVTRYKPHELYAGGDYPNQAPPGKGL
CCCEEEEECCCCEEEEECCCHHHHHHHHHCEEEEEEEEECCCEEEECCCCCCCCCCCCCC
PEYIADDESLMGQDIVLWYTMGITHVPKPEDWPVMPVHKLGFKLSPRGFFSRNPAINLPE
HHHHCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKRLKLFFLLAITIIICCGISLILIETVTAKQPVISHPLTALTEAEIKTAVALIRKEKS
CCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCC
LTDMAAFPLITLAEPDKQEVRNFTQGQSFERKAFLVVYERAQNKTYEGIVDLKTQKIASW
HHHHHHCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHH
QEKPHVQPAIFNSEYELARNVVKSDSRWQEAMKKRGITDFDQVQVSCWAAGILSQEEAAT
HHCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHEEEEHHHHHCCCHHHCC
GGRLCRTLLFYRGERWNYYGSPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLQSL
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCCCCHHHH
GKLLSPPKLLQILQPKGKSFQIQGNEVTWQGWKFRYVMHPRDGLVLYQVNYKDGGNVRPV
HHHCCCHHHHHHHCCCCCEEEEECCEEEECCEEEEEEECCCCCEEEEEEECCCCCCCCEE
LYRASLSEMVVPYGDPDPTWSFRNAFDVGEYNLGLLASTMELGKEIPQNGVLFDAVFANE
EEECCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
EGEPYVMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQLVITITAAVDNYDYGINWIFH
CCCCEECCCEEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCEEEEEE
QDGTLEVENDLTGIVLVQGTEAETQPEDNFYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
CCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
NNVMEMNVASLPIGKNNPIGNAIVVKDTPLKTEKAAVRDLDIKHSREWMIANADKKNALG
CCEEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCC
VAPAYMLMPGGNTVFFPVEGAKIRQKAEFATHHVWVTRYKPHELYAGGDYPNQAPPGKGL
CCCEEEEECCCCEEEEECCCHHHHHHHHHCEEEEEEEEECCCEEEECCCCCCCCCCCCCC
PEYIADDESLMGQDIVLWYTMGITHVPKPEDWPVMPVHKLGFKLSPRGFFSRNPAINLPE
HHHHCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876243 [H]