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The map label for this gene is pntB [H]

Identifier: 17230900

GI number: 17230900

Start: 4118352

End: 4119755

Strand: Reverse

Name: pntB [H]

Synonym: all3408

Alternate gene names: 17230900

Gene position: 4119755-4118352 (Counterclockwise)

Preceding gene: 17230901

Following gene: 17230896

Centisome position: 64.23

GC content: 46.87

Gene sequence:

>1404_bases
GTGAGCGACTTTTTACCAACTGGAATACAGCTGACGTACTTAGTCGCTGCATCCTTATTTATTCTGGGTTTGAAAAAATT
AGGTTCCCCAGCTACAGCGCGTAACGGGAATGTGATTGGCGCTGTGGGGATGTTGTTGGCAATTGTCGCCACAATGTTAG
ATCAGCACGTCCTCAATTATGAAATGATTTTGTTAGGTTTAGCGATTGGTTCAGGTATTGGTGCGATCGCTGCCTACAAA
GTCCAGATGACAGAAATGCCCCAAATGGTAGGTTTACTTAACGGTTTGGGTGGTGCGGCTTCGGCGTTAGTTGCTGTGGC
TGAGTTCTGGCGGTTATTGGATGCAGGCGCACCTGTACCCTTAGATGTGAACATCTCCATGTTGTTGGATGTGTTGATTG
GTGGTGTCACCTTCACAGGTAGTTTCCTCGCCTTCGCCAAATTGCAAGGATTAATTAGCGGTTCACCAATTACCTTTCCT
TTACAACAACCATTTAACCTCTTACTTTTGGGTGGTTATCTAGCTGGGAGCGCTTATTTAATCGTTACACCAGATAGCTT
ACCTGTATTCTTGGCAGTCGTTGCCGTTTCCCTAGTTTTGGGCGTGATGTTCGTCATCCCCATTGGTGGGGGAGATATGC
CGGTGGTAATTTCCCTGTTGAACTCTTTGTCAGGGATAGCGGCTGCTGCTGCTGGTTTCGTGGTGATGAACAATATGTTA
ATCATCGCCGGCGCATTGGTGGGGGCTTCCGGTTTAATCTTGACGGAAATCATGTGTAAAGCCATGAACCGTTCCCTCTT
CAGCGTCCTGTTTAGCGCTTTTGGTTCTGTGAGTGCAGGTGGCGCTGGTGCGGCTACTGGTACAACAGATCAAACAGTCC
ACAGCATCGATCCTGAAGAAGGCGCAATGATGTTGGGTTATGCTCGTTCTGTGGTGATTGTTCCTGGTTATGGGATGGCT
GTAGCTCAAGCACAACATAGTGTGAGAGAGTTGGCTGATCAATTAGAACGGATGGGTGTTGATGTTAAGTATGCCATTCA
CCCCGTTGCTGGGAGAATGCCCGGACACATGAACGTGTTGTTAGCTGAGGCGAATGTACCATATACCCAGTTGTATGACA
TGGAAGATATTAACCCCCAATTTGAGCAAGCAGATGTAGCTTTAGTGATTGGGGCGAATGATGTAGTCAATCCGGCGGCG
CGGAGTGATACCGCTAGTCCAATTTATGGGATGCCAATTTTGGAAGTAGATAGGGCGAAGCACACTATTGTAATTAAGCG
CGGGATGAGCGCAGGTTTTGCCGGTGTAGATAATGAGTTGTTTTACAAAGATAAAACCACAATGCTTTTTGGTAGTGCGA
AAGATATGGTGGCGAAGTTAGTTTCTGAAGTGAAGCAACTTTAG

Upstream 100 bases:

>100_bases
TAGGTTTGATTGCTGTGACTCTGGCAACAGTCAACGTTGTTGCTGGGTTTCTCGTTACCGACAGAATGTTGCAAATGTTC
AAGAAGAAGGAAGTTAAAGC

Downstream 100 bases:

>100_bases
GGAATTAAGAATAATTTCTAGGTTTACTTGCCTTGGGGGTGTGATGCTTCCGAGGCATTTTTTTTGTGTTTTATTCTGAA
ATCAATTATTCAAGCTCTGG

Product: nicotinamide nucleotide transhydrogenase, subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSDFLPTGIQLTYLVAASLFILGLKKLGSPATARNGNVIGAVGMLLAIVATMLDQHVLNYEMILLGLAIGSGIGAIAAYK
VQMTEMPQMVGLLNGLGGAASALVAVAEFWRLLDAGAPVPLDVNISMLLDVLIGGVTFTGSFLAFAKLQGLISGSPITFP
LQQPFNLLLLGGYLAGSAYLIVTPDSLPVFLAVVAVSLVLGVMFVIPIGGGDMPVVISLLNSLSGIAAAAAGFVVMNNML
IIAGALVGASGLILTEIMCKAMNRSLFSVLFSAFGSVSAGGAGAATGTTDQTVHSIDPEEGAMMLGYARSVVIVPGYGMA
VAQAQHSVRELADQLERMGVDVKYAIHPVAGRMPGHMNVLLAEANVPYTQLYDMEDINPQFEQADVALVIGANDVVNPAA
RSDTASPIYGMPILEVDRAKHTIVIKRGMSAGFAGVDNELFYKDKTTMLFGSAKDMVAKLVSEVKQL

Sequences:

>Translated_467_residues
MSDFLPTGIQLTYLVAASLFILGLKKLGSPATARNGNVIGAVGMLLAIVATMLDQHVLNYEMILLGLAIGSGIGAIAAYK
VQMTEMPQMVGLLNGLGGAASALVAVAEFWRLLDAGAPVPLDVNISMLLDVLIGGVTFTGSFLAFAKLQGLISGSPITFP
LQQPFNLLLLGGYLAGSAYLIVTPDSLPVFLAVVAVSLVLGVMFVIPIGGGDMPVVISLLNSLSGIAAAAAGFVVMNNML
IIAGALVGASGLILTEIMCKAMNRSLFSVLFSAFGSVSAGGAGAATGTTDQTVHSIDPEEGAMMLGYARSVVIVPGYGMA
VAQAQHSVRELADQLERMGVDVKYAIHPVAGRMPGHMNVLLAEANVPYTQLYDMEDINPQFEQADVALVIGANDVVNPAA
RSDTASPIYGMPILEVDRAKHTIVIKRGMSAGFAGVDNELFYKDKTTMLFGSAKDMVAKLVSEVKQL
>Mature_466_residues
SDFLPTGIQLTYLVAASLFILGLKKLGSPATARNGNVIGAVGMLLAIVATMLDQHVLNYEMILLGLAIGSGIGAIAAYKV
QMTEMPQMVGLLNGLGGAASALVAVAEFWRLLDAGAPVPLDVNISMLLDVLIGGVTFTGSFLAFAKLQGLISGSPITFPL
QQPFNLLLLGGYLAGSAYLIVTPDSLPVFLAVVAVSLVLGVMFVIPIGGGDMPVVISLLNSLSGIAAAAAGFVVMNNMLI
IAGALVGASGLILTEIMCKAMNRSLFSVLFSAFGSVSAGGAGAATGTTDQTVHSIDPEEGAMMLGYARSVVIVPGYGMAV
AQAQHSVRELADQLERMGVDVKYAIHPVAGRMPGHMNVLLAEANVPYTQLYDMEDINPQFEQADVALVIGANDVVNPAAR
SDTASPIYGMPILEVDRAKHTIVIKRGMSAGFAGVDNELFYKDKTTMLFGSAKDMVAKLVSEVKQL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=470, Percent_Identity=41.063829787234, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI122939153, Length=470, Percent_Identity=41.063829787234, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1787886, Length=450, Percent_Identity=49.1111111111111, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17550456, Length=461, Percent_Identity=42.5162689804772, Blast_Score=328, Evalue=5e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48564; Mature: 48433

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFLPTGIQLTYLVAASLFILGLKKLGSPATARNGNVIGAVGMLLAIVATMLDQHVLNY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EMILLGLAIGSGIGAIAAYKVQMTEMPQMVGLLNGLGGAASALVAVAEFWRLLDAGAPVP
HHHHHHHHHCCCCCHHHEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
LDVNISMLLDVLIGGVTFTGSFLAFAKLQGLISGSPITFPLQQPFNLLLLGGYLAGSAYL
ECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCEEE
IVTPDSLPVFLAVVAVSLVLGVMFVIPIGGGDMPVVISLLNSLSGIAAAAAGFVVMNNML
EECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIAGALVGASGLILTEIMCKAMNRSLFSVLFSAFGSVSAGGAGAATGTTDQTVHSIDPEE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCC
GAMMLGYARSVVIVPGYGMAVAQAQHSVRELADQLERMGVDVKYAIHPVAGRMPGHMNVL
CCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
LAEANVPYTQLYDMEDINPQFEQADVALVIGANDVVNPAARSDTASPIYGMPILEVDRAK
EEECCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCC
HTIVIKRGMSAGFAGVDNELFYKDKTTMLFGSAKDMVAKLVSEVKQL
EEEEEECCCCCCCCCCCCCEEECCCCEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDFLPTGIQLTYLVAASLFILGLKKLGSPATARNGNVIGAVGMLLAIVATMLDQHVLNY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EMILLGLAIGSGIGAIAAYKVQMTEMPQMVGLLNGLGGAASALVAVAEFWRLLDAGAPVP
HHHHHHHHHCCCCCHHHEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
LDVNISMLLDVLIGGVTFTGSFLAFAKLQGLISGSPITFPLQQPFNLLLLGGYLAGSAYL
ECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCEEE
IVTPDSLPVFLAVVAVSLVLGVMFVIPIGGGDMPVVISLLNSLSGIAAAAAGFVVMNNML
EECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIAGALVGASGLILTEIMCKAMNRSLFSVLFSAFGSVSAGGAGAATGTTDQTVHSIDPEE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCC
GAMMLGYARSVVIVPGYGMAVAQAQHSVRELADQLERMGVDVKYAIHPVAGRMPGHMNVL
CCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
LAEANVPYTQLYDMEDINPQFEQADVALVIGANDVVNPAARSDTASPIYGMPILEVDRAK
EEECCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCC
HTIVIKRGMSAGFAGVDNELFYKDKTTMLFGSAKDMVAKLVSEVKQL
EEEEEECCCCCCCCCCCCCEEECCCCEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]