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The map label for this gene is lipB [H]

Identifier: 17230677

GI number: 17230677

Start: 3854572

End: 3855237

Strand: Direct

Name: lipB [H]

Synonym: alr3185

Alternate gene names: 17230677

Gene position: 3854572-3855237 (Clockwise)

Preceding gene: 17230675

Following gene: 17230679

Centisome position: 60.1

GC content: 43.99

Gene sequence:

>666_bases
ATGATCCGTAGTAATAAACCCCCAGAGAACAATTGTTTGTTATATAACAAAGGATTAATGCCATATTTGGCAGCTCACGC
ATGGCAGCGATCGCTCTTGCGCCAACGCATCGATTACCCTAATCTAGAGGATGTACTGATATTACTGGAACATCCGCCAG
TCTACACTTTGGGGCAAGGCAGTAGTCTAGAATTTCTCAAATTTGACCCTAATCAAAGTGAGTTTGAGATACATCGAATT
GAACGGGGCGGAGAAGTTACTTACCACTGTCCAGGTCAATTAGTGGGGTATCCGATTTTAAATCTGCACCGCCATCGCCA
AGATTTGCACTGGTACTTGCGACAATTAGAAGAAGTTATCATCCGTGTACTAGCAGTTTACGACTTAAAAGGCGATCGCC
TGCCATCTTTGACTGGGGTTTGGTTAGAAGGGAGGAAAGTTGCAGCCATCGGCATTAAAGTTAGTCGTTGGATTACCATG
CACGGTTTTGCTTTAAATGTCTGTCCTGATATGACAGGCTTTAGCCGAATAGTCCCTTGTGGCATTACTGATAAGCCTGT
TGGCAGTTTAGCCCAATGGATACCAGGAATTACTTGTGAGGAAGTACGAGTTCATGTTGTCCAGGCTTTTGCAGAAGTGT
TTGGTCTGGAATTAGTTGACAGTTGA

Upstream 100 bases:

>100_bases
CCTTGATGTTCCTTTAAAATCCTTTGCAAAGCTTGACAATTGTTGACTCAGAAGCTGTGAGTTGAAATATATTTAGTTGT
AAAACCTGTTGATTTTTGGC

Downstream 100 bases:

>100_bases
CAGTTAACTGTTGACTGCTTCATCATGTAATAGGTGCAATCTACTACGAAAATTTGCATATATGAGAATATCCTGGTTCA
AGCTAGAATATGAATGCTTA

Product: lipoyltransferase

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQGSSLEFLKFDPNQSEFEIHRI
ERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVIIRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITM
HGFALNVCPDMTGFSRIVPCGITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS

Sequences:

>Translated_221_residues
MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQGSSLEFLKFDPNQSEFEIHRI
ERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVIIRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITM
HGFALNVCPDMTGFSRIVPCGITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS
>Mature_221_residues
MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQGSSLEFLKFDPNQSEFEIHRI
ERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVIIRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITM
HGFALNVCPDMTGFSRIVPCGITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=221, Percent_Identity=34.841628959276, Blast_Score=98, Evalue=5e-21,
Organism=Escherichia coli, GI87081767, Length=194, Percent_Identity=30.4123711340206, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323268, Length=156, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355483, Length=208, Percent_Identity=35.5769230769231, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 25207; Mature: 25207

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQG
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCEEEECCC
SSLEFLKFDPNQSEFEIHRIERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVI
CCEEEEEECCCCCCEEEEEECCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
IRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITMHGFALNVCPDMTGFSRIVPC
HHHHHHHCCCCCCCCCCEEEEECCCEEEEEEEEEEEEEEECCEEEECCCCCCCCCCEEEC
GITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRSNKPPENNCLLYNKGLMPYLAAHAWQRSLLRQRIDYPNLEDVLILLEHPPVYTLGQG
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCEEEECCC
SSLEFLKFDPNQSEFEIHRIERGGEVTYHCPGQLVGYPILNLHRHRQDLHWYLRQLEEVI
CCEEEEEECCCCCCEEEEEECCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHH
IRVLAVYDLKGDRLPSLTGVWLEGRKVAAIGIKVSRWITMHGFALNVCPDMTGFSRIVPC
HHHHHHHCCCCCCCCCCEEEEECCCEEEEEEEEEEEEEEECCEEEECCCCCCCCCCEEEC
GITDKPVGSLAQWIPGITCEEVRVHVVQAFAEVFGLELVDS
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA