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The map label for this gene is srrB [H]

Identifier: 17230647

GI number: 17230647

Start: 3819488

End: 3820522

Strand: Direct

Name: srrB [H]

Synonym: alr3155

Alternate gene names: 17230647

Gene position: 3819488-3820522 (Clockwise)

Preceding gene: 17230642

Following gene: 17230648

Centisome position: 59.55

GC content: 41.26

Gene sequence:

>1035_bases
GTGATTTCTATGGAGTTTTCTACGCCAACAGAATATGTATTTGGATATCTTTATACTGGGCCAATTCTGTTAGCTAATCA
CTGGTTTGGACGTATAGCAACTTTATTGACGACATTTATTGCTGTATTTTTAACAATTCTTAATCTTGGTTTTCCAAATA
ATGAAGTGATTAGGTTTCCTACAGTTGCTAGTCGGATGATCGCTTGTATGTCCTTAATTGTAACAGGGATTTTAAGCGAT
CGCCTGCGTCGTTCTCAAGAGGCGATCGCCCTCACCCGTGCCAAATTAGAATCACAGGAAGAATTAGTCAGACTGCGGGA
AGATTTTGCTTCTACTCTCACCCACGATTTGAAAACACCGCTTTTGGGTGCTATTGAAACTCTCAAAGCTGTTCAACAAG
AAAAATTTGGTGCGGTATCATCAGCACAGCAGCCGGTGTTAGCCACAATTATCCGCAGCCATCAAACTTCTCTACAACTC
CTAGAAACTTTATTAGATATCTATCGCAATGATACAGAAGGTTTACAGCTCAATTTAATTCCTGTGGATTTAACCACTTT
GGCAGAAGAAGCAGCGAGTACACTAATTGATTTGGCTGCTAGTCGGCGAGTTCATATATCGTTTAATTATGGTGACTCTG
ATTGGCGGCGATCGCTGTGGGTAAACGGTGATCCTCTGCAATTGCAACGGGTGTTGTATAATCTCCTAGTCAATGCTATC
AATCATTCTCGGCGGGGCGATCGTGTAGAGGTTGTATTGGAAACCCAAGCTTCCTATCAAGTAGTAAAAATTTCCGATAC
TGGCGCAGGTATTCAAGCAGAACAGTTTCCTCATTTATTTGAACGATTTTATCAAGGCCATAGTGAACGCCAAGCCAAAG
GTTCAGGTTTAGGACTTTATTTATCTCGACAAATTATTGCAGCTCATAACGGTATAATTTGGGCAGAGAATAGAGTTCCT
ACGGGTGCTATGTTTGCATTCAAATTGCCTTTTCTCCCATTTCAGCCCTCTTTATCTGCGTCAGATGGCTTCTAA

Upstream 100 bases:

>100_bases
AAATTACGAATTAATATAAATGCTATCCCGGCGAACTAAATTACTATCCCAAAACTCATTTTTGGTAAAAGCCTCAGTCA
TCTTAGGGCTATTGATCACA

Downstream 100 bases:

>100_bases
CCCGGTAAAAATTCTGTTGGTTGAAGATGATGAACTCTTTCGCTTAGGCTTGCGGGTGCGATTACAACAAGAAGCAGGCT
TAGAAATTATTGCTGAGGCT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTILNLGFPNNEVIRFPTVASRMIACMSLIVTGILSD
RLRRSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQEKFGAVSSAQQPVLATIIRSHQTSLQL
LETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDSDWRRSLWVNGDPLQLQRVLYNLLVNAI
NHSRRGDRVEVVLETQASYQVVKISDTGAGIQAEQFPHLFERFYQGHSERQAKGSGLGLYLSRQIIAAHNGIIWAENRVP
TGAMFAFKLPFLPFQPSLSASDGF

Sequences:

>Translated_344_residues
MISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTILNLGFPNNEVIRFPTVASRMIACMSLIVTGILSD
RLRRSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQEKFGAVSSAQQPVLATIIRSHQTSLQL
LETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDSDWRRSLWVNGDPLQLQRVLYNLLVNAI
NHSRRGDRVEVVLETQASYQVVKISDTGAGIQAEQFPHLFERFYQGHSERQAKGSGLGLYLSRQIIAAHNGIIWAENRVP
TGAMFAFKLPFLPFQPSLSASDGF
>Mature_344_residues
MISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTILNLGFPNNEVIRFPTVASRMIACMSLIVTGILSD
RLRRSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTPLLGAIETLKAVQQEKFGAVSSAQQPVLATIIRSHQTSLQL
LETLLDIYRNDTEGLQLNLIPVDLTTLAEEAASTLIDLAASRRVHISFNYGDSDWRRSLWVNGDPLQLQRVLYNLLVNAI
NHSRRGDRVEVVLETQASYQVVKISDTGAGIQAEQFPHLFERFYQGHSERQAKGSGLGLYLSRQIIAAHNGIIWAENRVP
TGAMFAFKLPFLPFQPSLSASDGF

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=29.0598290598291, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=29.1338582677165, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=26.1194029850746, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=245, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=27.4261603375527, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=30.859375, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=28.3261802575107, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=26.5060240963855, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=25.1063829787234, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=24.4, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=24.6428571428571, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=206, Percent_Identity=29.6116504854369, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788549, Length=291, Percent_Identity=26.1168384879725, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38467; Mature: 38467

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTILNLGFPNNEVIRFP
CEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
TVASRMIACMSLIVTGILSDRLRRSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LLGAIETLKAVQQEKFGAVSSAQQPVLATIIRSHQTSLQLLETLLDIYRNDTEGLQLNLI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PVDLTTLAEEAASTLIDLAASRRVHISFNYGDSDWRRSLWVNGDPLQLQRVLYNLLVNAI
ECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
NHSRRGDRVEVVLETQASYQVVKISDTGAGIQAEQFPHLFERFYQGHSERQAKGSGLGLY
HCCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHH
LSRQIIAAHNGIIWAENRVPTGAMFAFKLPFLPFQPSLSASDGF
HHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MISMEFSTPTEYVFGYLYTGPILLANHWFGRIATLLTTFIAVFLTILNLGFPNNEVIRFP
CEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
TVASRMIACMSLIVTGILSDRLRRSQEAIALTRAKLESQEELVRLREDFASTLTHDLKTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LLGAIETLKAVQQEKFGAVSSAQQPVLATIIRSHQTSLQLLETLLDIYRNDTEGLQLNLI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PVDLTTLAEEAASTLIDLAASRRVHISFNYGDSDWRRSLWVNGDPLQLQRVLYNLLVNAI
ECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
NHSRRGDRVEVVLETQASYQVVKISDTGAGIQAEQFPHLFERFYQGHSERQAKGSGLGLY
HCCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHH
LSRQIIAAHNGIIWAENRVPTGAMFAFKLPFLPFQPSLSASDGF
HHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA