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The map label for this gene is coaBC [H]

Identifier: 17230603

GI number: 17230603

Start: 3762327

End: 3763559

Strand: Reverse

Name: coaBC [H]

Synonym: all3111

Alternate gene names: 17230603

Gene position: 3763559-3762327 (Counterclockwise)

Preceding gene: 17230604

Following gene: 17230602

Centisome position: 58.68

GC content: 45.01

Gene sequence:

>1233_bases
ATGGCTCATCCTCAACCGCAAGCTGAAAATCGCAAAAGTAGGGTTCTTGTTGCTGTGGGTGGCGGTATCGCTGCTTATAA
GGTTTGTGAGGTCGTTTCGAATTTGTTTAAGTCGGGGGTGGAAGTTCGAGTCATTCTTACCCGTTCCGCACAAGAATTTA
TAACGCCTTTAACTTTATCAACCCTCTCCCGTCACCCTGCTTATACAGATGATGATTTTTGGCAATCTACTCACTCTCGT
CCGTTGCATATCGAGTTGGGTGAGTGGGCGGATTTGTTGGTGATTGCTCCCCTCACCGCTAATACCTTAGCTAAACTCAC
TTACGGGATGGCTGATAATTTACTCACCAATACAGTGTTAGCTTCCAATTGTCCCGCATTGTTAGCGCCGGCGATGAATA
CTGATATGTGGGAACAACTCACTGTGCAGCGTAATTGGCAGCAGTTGTTAACAGATAGCAGATATCATGGTATTGGCACA
GCATCGGGATTATTGGCGTGCGATCGCGTCGGTGCTGGTAGAATGGCGGAACCTCCAGAGATTTTGGCTTACACTCAATC
TCTATTACATACTCAAGGTAAGCGAGATTTAGCCGGGAAGCGAGTTTTAATTAGTGCGGGAGGTACAAGGGAGTATCTTG
ACCCGGTGCGATTTATTGGTAATCCTTCTACTGGTAAAATGGGACTGGCTTTAGCCCAAGCTGCTTTACACCGTGGGGCA
AAGGTGACATTGGTGCATGGGGTGGCGAGTTGGGTTGTACCTTTGGGTGTGCAAGCAATTCCCATTATCAATGCCGAAGA
AATGCAGCAGGTAATGTTGGAATATTTACCCAATGCAGATATCATCGTTATGTCTGCGGCTGTGGCTGATGTCAAACCTC
AAGATTATAGTACAGAAAAATTACCCAAGCGATCGCTCCCCCAGTCTTTACCTTTGGAACCAGTACCCGATATCGTTGCT
CAATTAGGTAAACTCAAACAACCCCATCAGCGTTTAATTGGTTTTGCTGCTCAGACAGGGGATATAGTTACACCAGCTAA
AGAGAAATTATATAGTAAGAAATTAGATGCGATCGTTGCAAACCCCATCGACAAAGCAGATAGTGGTTTTGGTAGCGATA
ATAATCAAGCTATCTTCTTAGATAACCAAGATAGACAAGTGACAATCCCACCTTGTTCTAAATTGCAACTAGCTCACCAT
CTCTTCGATTTTGTCAGCAACCTGACACTATGA

Upstream 100 bases:

>100_bases
TTTGGAACCATACGACGAAGCTTAGGTATTTGATAATCAGGAGTTAGAAATAATTCGTCCTTAAGAATTATCTCTAACTC
CTTACTCTTCAGTTTTTGTT

Downstream 100 bases:

>100_bases
TTCAGTAAGACAGAGCAACTGAGGTACACCCCAATCTTCTCAAACAAGGTTAGTAAAGTCGAAAATATACCTCACCAACT
CAGGAACCAGTATATCCCCA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAHPQPQAENRKSRVLVAVGGGIAAYKVCEVVSNLFKSGVEVRVILTRSAQEFITPLTLSTLSRHPAYTDDDFWQSTHSR
PLHIELGEWADLLVIAPLTANTLAKLTYGMADNLLTNTVLASNCPALLAPAMNTDMWEQLTVQRNWQQLLTDSRYHGIGT
ASGLLACDRVGAGRMAEPPEILAYTQSLLHTQGKRDLAGKRVLISAGGTREYLDPVRFIGNPSTGKMGLALAQAALHRGA
KVTLVHGVASWVVPLGVQAIPIINAEEMQQVMLEYLPNADIIVMSAAVADVKPQDYSTEKLPKRSLPQSLPLEPVPDIVA
QLGKLKQPHQRLIGFAAQTGDIVTPAKEKLYSKKLDAIVANPIDKADSGFGSDNNQAIFLDNQDRQVTIPPCSKLQLAHH
LFDFVSNLTL

Sequences:

>Translated_410_residues
MAHPQPQAENRKSRVLVAVGGGIAAYKVCEVVSNLFKSGVEVRVILTRSAQEFITPLTLSTLSRHPAYTDDDFWQSTHSR
PLHIELGEWADLLVIAPLTANTLAKLTYGMADNLLTNTVLASNCPALLAPAMNTDMWEQLTVQRNWQQLLTDSRYHGIGT
ASGLLACDRVGAGRMAEPPEILAYTQSLLHTQGKRDLAGKRVLISAGGTREYLDPVRFIGNPSTGKMGLALAQAALHRGA
KVTLVHGVASWVVPLGVQAIPIINAEEMQQVMLEYLPNADIIVMSAAVADVKPQDYSTEKLPKRSLPQSLPLEPVPDIVA
QLGKLKQPHQRLIGFAAQTGDIVTPAKEKLYSKKLDAIVANPIDKADSGFGSDNNQAIFLDNQDRQVTIPPCSKLQLAHH
LFDFVSNLTL
>Mature_409_residues
AHPQPQAENRKSRVLVAVGGGIAAYKVCEVVSNLFKSGVEVRVILTRSAQEFITPLTLSTLSRHPAYTDDDFWQSTHSRP
LHIELGEWADLLVIAPLTANTLAKLTYGMADNLLTNTVLASNCPALLAPAMNTDMWEQLTVQRNWQQLLTDSRYHGIGTA
SGLLACDRVGAGRMAEPPEILAYTQSLLHTQGKRDLAGKRVLISAGGTREYLDPVRFIGNPSTGKMGLALAQAALHRGAK
VTLVHGVASWVVPLGVQAIPIINAEEMQQVMLEYLPNADIIVMSAAVADVKPQDYSTEKLPKRSLPQSLPLEPVPDIVAQ
LGKLKQPHQRLIGFAAQTGDIVTPAKEKLYSKKLDAIVANPIDKADSGFGSDNNQAIFLDNQDRQVTIPPCSKLQLAHHL
FDFVSNLTL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=186, Percent_Identity=39.7849462365591, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=37.6884422110553, Blast_Score=222, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17560194, Length=201, Percent_Identity=32.3383084577114, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=30.5699481865285, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322925, Length=184, Percent_Identity=29.3478260869565, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324629, Length=85, Percent_Identity=44.7058823529412, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=36.6666666666667, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44564; Mature: 44433

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHPQPQAENRKSRVLVAVGGGIAAYKVCEVVSNLFKSGVEVRVILTRSAQEFITPLTLS
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHH
TLSRHPAYTDDDFWQSTHSRPLHIELGEWADLLVIAPLTANTLAKLTYGMADNLLTNTVL
HHHCCCCCCCHHHHHHHCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ASNCPALLAPAMNTDMWEQLTVQRNWQQLLTDSRYHGIGTASGLLACDRVGAGRMAEPPE
HCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
ILAYTQSLLHTQGKRDLAGKRVLISAGGTREYLDPVRFIGNPSTGKMGLALAQAALHRGA
HHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
KVTLVHGVASWVVPLGVQAIPIINAEEMQQVMLEYLPNADIIVMSAAVADVKPQDYSTEK
EEEEEHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCHHH
LPKRSLPQSLPLEPVPDIVAQLGKLKQPHQRLIGFAAQTGDIVTPAKEKLYSKKLDAIVA
CCHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
NPIDKADSGFGSDNNQAIFLDNQDRQVTIPPCSKLQLAHHLFDFVSNLTL
CCCCCCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AHPQPQAENRKSRVLVAVGGGIAAYKVCEVVSNLFKSGVEVRVILTRSAQEFITPLTLS
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHH
TLSRHPAYTDDDFWQSTHSRPLHIELGEWADLLVIAPLTANTLAKLTYGMADNLLTNTVL
HHHCCCCCCCHHHHHHHCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ASNCPALLAPAMNTDMWEQLTVQRNWQQLLTDSRYHGIGTASGLLACDRVGAGRMAEPPE
HCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
ILAYTQSLLHTQGKRDLAGKRVLISAGGTREYLDPVRFIGNPSTGKMGLALAQAALHRGA
HHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
KVTLVHGVASWVVPLGVQAIPIINAEEMQQVMLEYLPNADIIVMSAAVADVKPQDYSTEK
EEEEEHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCHHH
LPKRSLPQSLPLEPVPDIVAQLGKLKQPHQRLIGFAAQTGDIVTPAKEKLYSKKLDAIVA
CCHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
NPIDKADSGFGSDNNQAIFLDNQDRQVTIPPCSKLQLAHHLFDFVSNLTL
CCCCCCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]