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The map label for this gene is purH [H]

Identifier: 17230585

GI number: 17230585

Start: 3745060

End: 3746580

Strand: Reverse

Name: purH [H]

Synonym: all3093

Alternate gene names: 17230585

Gene position: 3746580-3745060 (Counterclockwise)

Preceding gene: 17230586

Following gene: 17230579

Centisome position: 58.41

GC content: 48.26

Gene sequence:

>1521_bases
ATGGCGCGTCTAGCACTGCTGAGTGTATCTAACAAGACTGGTTTAATTGACTTAGCTCGTCGCTTGGTGGAGGAATTTGA
GTTTGATTTAATCAGCAGTGGGGGGACAGCCCAAGCCCTCAAGGATGCTGGTTTACCTGTGACGAAGGTTGCAGATTACA
CGGGTTCGCCAGAGATTTTGGGTGGACGGGTGAAAACTCTACATCCCCGGATTCATGGGGGGATTTTGGCTAGGCGGGAT
GTAGCTAGTGATTTGACAGATTTGGAAAATAACCAAATTCGCCCGATTGATTTGGTGGTGGTGAATCTTTATCCCTTTGA
GTCTACTATTGCTAAACCAGGGGTGACGTTGGCGGAAGCTGTGGAACAAATTGACATTGGCGGCCCGGCGATGTTGCGGG
CATCATCGAAGAATTTTGCTCATCTGACGGTATTATGTGATCCGGCGCAGTATGACGAGTATTTGCAAGAATTACGGCAA
AATAACGGAGTGGCTTCCTTAGAATTTCGGCAAAAGGCGGCTTTGAAAGGGTTTTTACATACAGCAAGTTATGATAGCGC
TATAGCCTCTTACCTCTCAGGTACACAACAGCACACCCTAAGCGGTACTGAATTACAATCTCTGCGTTACGGTGAGAACC
CCCATCAGCCAGCAGCTTGGTATCAAACGGGGACTACGCCAACAGGGTGGACAGCAGCCGAGAAACTGCAAGGTAAGGAA
CTGAGTTACAATAACTTGGTTGACTTAGAAGCCGCCCGACGCATTATTGCAGAGTTCACTGATACACCAGCCGCAACGAT
TATTAAACATACTAATCCCTGCGGTACGGCGTTGGCAGATACCATTGTGGAGGCTTACCAAAAGGCTTTTAATGCTGATG
CTACTTCGGCATTTGGGGGGATTGTCGCCCTGAACCGTCCTATTGATGCAGCGACAGCCAGCGAGTTAACCAAGACGTTT
TTAGAATGTGTGATTGCGCCTGATTGTGATGCAGAAGCGCAAAAAATCCTCTCCAAGAAATCTAATGTGCGGGTGTTGAC
TTTGGCTGATTTGAGTACCGGCCCTAAAACTTTAGTCAAACAAATCGCCGGGGGTTTCCTGGTGCAGGCTGCGGATGATA
TTGCTGCTGACACAAGTCAATGGCAAGTCGTGACAGAACGCCAACCTACACCCGATGAATTAGCAGAATTGCTGTTTGCT
TGGAAAGTCTGCAAACACGTTAAATCTAATGCTATTGTTGTGACAAGCGATCGCACTACTCTAGGTGTAGGTGCAGGACA
AATGAACCGCATTGGTTCAACGAAAATTGCCTTAGAACAAGCTGGAGACAAAGCTAAAGGTGCAATCCTCGCCAGCGATG
GATTTTTCCCCTTCGATGATACAGTGAGAACCGCCGCCGCCGCCGGTATTAGCGCCATTGTCCAACCAGGGGGAAGCCTG
CGGGATCAAGATTCTGTCAAAGCTGCTAATGAACTCGGTTTGCTGATGGTGTTGACTGGGGTGCGTCACTTTTTACACTA
A

Upstream 100 bases:

>100_bases
TCACTAAAATATGATGGCTGATTATGTTATTCCTGATGCCCTTGAAGTGAAGCAAGGGTTGTGTGAAAATTGGGGTCTTT
GGCATCTGAGGAATTGAGAC

Downstream 100 bases:

>100_bases
AGATGGGTGTAGAGGAGCGCTTGATTATTTGATAACTAGCGAATGCTCATCAGAAAACCTCTGCGTGCCTTGGCGCTAAC
CTTAGCGTTACTCAGCGTTA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MARLALLSVSNKTGLIDLARRLVEEFEFDLISSGGTAQALKDAGLPVTKVADYTGSPEILGGRVKTLHPRIHGGILARRD
VASDLTDLENNQIRPIDLVVVNLYPFESTIAKPGVTLAEAVEQIDIGGPAMLRASSKNFAHLTVLCDPAQYDEYLQELRQ
NNGVASLEFRQKAALKGFLHTASYDSAIASYLSGTQQHTLSGTELQSLRYGENPHQPAAWYQTGTTPTGWTAAEKLQGKE
LSYNNLVDLEAARRIIAEFTDTPAATIIKHTNPCGTALADTIVEAYQKAFNADATSAFGGIVALNRPIDAATASELTKTF
LECVIAPDCDAEAQKILSKKSNVRVLTLADLSTGPKTLVKQIAGGFLVQAADDIAADTSQWQVVTERQPTPDELAELLFA
WKVCKHVKSNAIVVTSDRTTLGVGAGQMNRIGSTKIALEQAGDKAKGAILASDGFFPFDDTVRTAAAAGISAIVQPGGSL
RDQDSVKAANELGLLMVLTGVRHFLH

Sequences:

>Translated_506_residues
MARLALLSVSNKTGLIDLARRLVEEFEFDLISSGGTAQALKDAGLPVTKVADYTGSPEILGGRVKTLHPRIHGGILARRD
VASDLTDLENNQIRPIDLVVVNLYPFESTIAKPGVTLAEAVEQIDIGGPAMLRASSKNFAHLTVLCDPAQYDEYLQELRQ
NNGVASLEFRQKAALKGFLHTASYDSAIASYLSGTQQHTLSGTELQSLRYGENPHQPAAWYQTGTTPTGWTAAEKLQGKE
LSYNNLVDLEAARRIIAEFTDTPAATIIKHTNPCGTALADTIVEAYQKAFNADATSAFGGIVALNRPIDAATASELTKTF
LECVIAPDCDAEAQKILSKKSNVRVLTLADLSTGPKTLVKQIAGGFLVQAADDIAADTSQWQVVTERQPTPDELAELLFA
WKVCKHVKSNAIVVTSDRTTLGVGAGQMNRIGSTKIALEQAGDKAKGAILASDGFFPFDDTVRTAAAAGISAIVQPGGSL
RDQDSVKAANELGLLMVLTGVRHFLH
>Mature_505_residues
ARLALLSVSNKTGLIDLARRLVEEFEFDLISSGGTAQALKDAGLPVTKVADYTGSPEILGGRVKTLHPRIHGGILARRDV
ASDLTDLENNQIRPIDLVVVNLYPFESTIAKPGVTLAEAVEQIDIGGPAMLRASSKNFAHLTVLCDPAQYDEYLQELRQN
NGVASLEFRQKAALKGFLHTASYDSAIASYLSGTQQHTLSGTELQSLRYGENPHQPAAWYQTGTTPTGWTAAEKLQGKEL
SYNNLVDLEAARRIIAEFTDTPAATIIKHTNPCGTALADTIVEAYQKAFNADATSAFGGIVALNRPIDAATASELTKTFL
ECVIAPDCDAEAQKILSKKSNVRVLTLADLSTGPKTLVKQIAGGFLVQAADDIAADTSQWQVVTERQPTPDELAELLFAW
KVCKHVKSNAIVVTSDRTTLGVGAGQMNRIGSTKIALEQAGDKAKGAILASDGFFPFDDTVRTAAAAGISAIVQPGGSLR
DQDSVKAANELGLLMVLTGVRHFLH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=471, Percent_Identity=39.2781316348195, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1790439, Length=526, Percent_Identity=46.3878326996198, Blast_Score=457, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=36.4978902953587, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71985574, Length=302, Percent_Identity=26.4900662251656, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323768, Length=472, Percent_Identity=39.4067796610169, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6323056, Length=473, Percent_Identity=39.1120507399577, Blast_Score=274, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24649832, Length=467, Percent_Identity=40.8993576017131, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 54036; Mature: 53905

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLALLSVSNKTGLIDLARRLVEEFEFDLISSGGTAQALKDAGLPVTKVADYTGSPEIL
CCCEEEEEECCCCCHHHHHHHHHHHHCHHHCCCCCHHHHHHHCCCCHHHHCCCCCCCHHC
GGRVKTLHPRIHGGILARRDVASDLTDLENNQIRPIDLVVVNLYPFESTIAKPGVTLAEA
CCCCEEECCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHCCCCCHHHHH
VEQIDIGGPAMLRASSKNFAHLTVLCDPAQYDEYLQELRQNNGVASLEFRQKAALKGFLH
HHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
TASYDSAIASYLSGTQQHTLSGTELQSLRYGENPHQPAAWYQTGTTPTGWTAAEKLQGKE
HCCHHHHHHHHHCCCHHHCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHCCCC
LSYNNLVDLEAARRIIAEFTDTPAATIIKHTNPCGTALADTIVEAYQKAFNADATSAFGG
CCCCCEECHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHCCC
IVALNRPIDAATASELTKTFLECVIAPDCDAEAQKILSKKSNVRVLTLADLSTGPKTLVK
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
QIAGGFLVQAADDIAADTSQWQVVTERQPTPDELAELLFAWKVCKHVKSNAIVVTSDRTT
HHHCCEEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
LGVGAGQMNRIGSTKIALEQAGDKAKGAILASDGFFPFDDTVRTAAAAGISAIVQPGGSL
EEECCCCCCCCCCCEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
RDQDSVKAANELGLLMVLTGVRHFLH
CCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARLALLSVSNKTGLIDLARRLVEEFEFDLISSGGTAQALKDAGLPVTKVADYTGSPEIL
CCEEEEEECCCCCHHHHHHHHHHHHCHHHCCCCCHHHHHHHCCCCHHHHCCCCCCCHHC
GGRVKTLHPRIHGGILARRDVASDLTDLENNQIRPIDLVVVNLYPFESTIAKPGVTLAEA
CCCCEEECCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHCCCCCHHHHH
VEQIDIGGPAMLRASSKNFAHLTVLCDPAQYDEYLQELRQNNGVASLEFRQKAALKGFLH
HHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
TASYDSAIASYLSGTQQHTLSGTELQSLRYGENPHQPAAWYQTGTTPTGWTAAEKLQGKE
HCCHHHHHHHHHCCCHHHCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHCCCC
LSYNNLVDLEAARRIIAEFTDTPAATIIKHTNPCGTALADTIVEAYQKAFNADATSAFGG
CCCCCEECHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHCCC
IVALNRPIDAATASELTKTFLECVIAPDCDAEAQKILSKKSNVRVLTLADLSTGPKTLVK
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
QIAGGFLVQAADDIAADTSQWQVVTERQPTPDELAELLFAWKVCKHVKSNAIVVTSDRTT
HHHCCEEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
LGVGAGQMNRIGSTKIALEQAGDKAKGAILASDGFFPFDDTVRTAAAAGISAIVQPGGSL
EEECCCCCCCCCCCEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
RDQDSVKAANELGLLMVLTGVRHFLH
CCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA