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The map label for this gene is siaT [H]

Identifier: 17230519

GI number: 17230519

Start: 3666671

End: 3668008

Strand: Direct

Name: siaT [H]

Synonym: alr3027

Alternate gene names: 17230519

Gene position: 3666671-3668008 (Clockwise)

Preceding gene: 17230518

Following gene: 17230529

Centisome position: 57.17

GC content: 43.12

Gene sequence:

>1338_bases
ATGACACTGGCTTATGAATGGTTGGGGCCAGTGATGTTTGCTGGTGCTTTAGTTCTATTATCTTCAGGCTACCCAGTAGC
TTTTTCTTTGGGTGGAGTAGCGATTTTATTTGGATTGTTGGGAATTGGTTTAGGTGTCTTTGACCCTATATTCCTCACAG
CCATGCCACAGCGTATTTTCGGCATTATGGCTAATTATACCCTGTTAGCAATCCCTTATTTTATTTTTATGGGGGCAATG
TTAGAAAAATCTGGCATTGCCGAAAGACTCCTAGAAACAATGGGTATTTTGTTAGGACGCTTGCGTGGTGGACTTGCTTT
AGCCGTTGTCTTAGTAGGCGCATTATTAGCTGCAACCACTGGTGTAGTAGCAGCCACAGTGGTGGCAATGGGTTTGATTT
CTCTACCGATTATGCTGCGCTATGGATACAACAAAGAATTAGCCACTGGTGTGATTGCTGCATCGGGAACCTTGGGACAA
ATTATCCCGCCGAGTGTGGTGTTAGTTGTATTAGGTGATCAATTGGGTATATCGGTAGGAGACTTGTTCATTGGTTCCGT
GATTCCAGGTTTGATGATGGCAAGTGCTTTTGCCCTTCATGTATTAATTGTGGCTTTCATCAGACCGGATGTAGCTCCAG
CCTTACCTGCCCAAGTGAGAGAAATCGGTGGTAAAGCCTTGGGAAAAAGGGTGATACAGGTGATGATACCGCCTTTGATA
CTGATTTTATTAGTATTGGGGAGTATCTTTTTTGGCTTTGCTACACCAACAGAAGCAGGTGCAGTAGGTTGTGCTGGGGC
GATCGCTCTTGCGGCTGCTAATGGTCAATTCACTTTAGAATCATTACGCCAAGTCTGCGATACTACCTTACGCATCACTA
GTATGGTAGTTTTTATCCTCATTGGCTCCACTGCATTTAGTTTAGTGTTCCGGGGATTGAACGGCGATCAATTCATGTTC
GATGTCCTAGCCAATCTCCCTGGTGGTAAAATCGGCTTTTTGTTTGTCAGCATGACGACAGTATTTCTTTTGGGCTTTTT
CATCGATTTTTTCGAGATTGCCTTTATTGTCATACCTTTATTTGTTCCAGTTGCCCAAAAATTAGGCATTGACTTAGTTT
GGTACGGTGTGATTTTAGGCGCAAATTTGCAAACATCCTTTCTCACACCACCCTTTGGCTTTGCCTTATTTTATTTACGA
GGTGTAGCACCACCAGAAGTCACCACATCAGATATTTATCGCGGTGTCATACCCTTTATTCTCTTGCAACTTTTAGTCCT
GCTGTTAATCATTATTTTCCCCGGAATTGTCAGTTTCCTACCATCTTTGGGAAGTTAA

Upstream 100 bases:

>100_bases
ATTATCGTTGGCTTTGTGTTGTTAATTATTCAAGGAATTTCCCAAGCAATTAAAAATTTAGCAATTATCCAAGGCAGACT
AGAACCCCAGGAGGAAAATC

Downstream 100 bases:

>100_bases
AGTATTGGTAATTACGCAGTTTTCTTTTGCATTAAGTACAAGGTTATTAGTTTTAAGGCAGTCCCGATGAAAAAATTTCA
CAGTCATAGATGAAAGATAT

Product: hypothetical protein

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTLAYEWLGPVMFAGALVLLSSGYPVAFSLGGVAILFGLLGIGLGVFDPIFLTAMPQRIFGIMANYTLLAIPYFIFMGAM
LEKSGIAERLLETMGILLGRLRGGLALAVVLVGALLAATTGVVAATVVAMGLISLPIMLRYGYNKELATGVIAASGTLGQ
IIPPSVVLVVLGDQLGISVGDLFIGSVIPGLMMASAFALHVLIVAFIRPDVAPALPAQVREIGGKALGKRVIQVMIPPLI
LILLVLGSIFFGFATPTEAGAVGCAGAIALAAANGQFTLESLRQVCDTTLRITSMVVFILIGSTAFSLVFRGLNGDQFMF
DVLANLPGGKIGFLFVSMTTVFLLGFFIDFFEIAFIVIPLFVPVAQKLGIDLVWYGVILGANLQTSFLTPPFGFALFYLR
GVAPPEVTTSDIYRGVIPFILLQLLVLLLIIIFPGIVSFLPSLGS

Sequences:

>Translated_445_residues
MTLAYEWLGPVMFAGALVLLSSGYPVAFSLGGVAILFGLLGIGLGVFDPIFLTAMPQRIFGIMANYTLLAIPYFIFMGAM
LEKSGIAERLLETMGILLGRLRGGLALAVVLVGALLAATTGVVAATVVAMGLISLPIMLRYGYNKELATGVIAASGTLGQ
IIPPSVVLVVLGDQLGISVGDLFIGSVIPGLMMASAFALHVLIVAFIRPDVAPALPAQVREIGGKALGKRVIQVMIPPLI
LILLVLGSIFFGFATPTEAGAVGCAGAIALAAANGQFTLESLRQVCDTTLRITSMVVFILIGSTAFSLVFRGLNGDQFMF
DVLANLPGGKIGFLFVSMTTVFLLGFFIDFFEIAFIVIPLFVPVAQKLGIDLVWYGVILGANLQTSFLTPPFGFALFYLR
GVAPPEVTTSDIYRGVIPFILLQLLVLLLIIIFPGIVSFLPSLGS
>Mature_444_residues
TLAYEWLGPVMFAGALVLLSSGYPVAFSLGGVAILFGLLGIGLGVFDPIFLTAMPQRIFGIMANYTLLAIPYFIFMGAML
EKSGIAERLLETMGILLGRLRGGLALAVVLVGALLAATTGVVAATVVAMGLISLPIMLRYGYNKELATGVIAASGTLGQI
IPPSVVLVVLGDQLGISVGDLFIGSVIPGLMMASAFALHVLIVAFIRPDVAPALPAQVREIGGKALGKRVIQVMIPPLIL
ILLVLGSIFFGFATPTEAGAVGCAGAIALAAANGQFTLESLRQVCDTTLRITSMVVFILIGSTAFSLVFRGLNGDQFMFD
VLANLPGGKIGFLFVSMTTVFLLGFFIDFFEIAFIVIPLFVPVAQKLGIDLVWYGVILGANLQTSFLTPPFGFALFYLRG
VAPPEVTTSDIYRGVIPFILLQLLVLLLIIIFPGIVSFLPSLGS

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG4664

COG function: function code Q; TRAP-type mannitol/chloroaromatic compound transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=399, Percent_Identity=27.8195488721804, Blast_Score=111, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 46826; Mature: 46695

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLAYEWLGPVMFAGALVLLSSGYPVAFSLGGVAILFGLLGIGLGVFDPIFLTAMPQRIF
CEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIMANYTLLAIPYFIFMGAMLEKSGIAERLLETMGILLGRLRGGLALAVVLVGALLAATT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVAATVVAMGLISLPIMLRYGYNKELATGVIAASGTLGQIIPPSVVLVVLGDQLGISVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHEEEEECCHHCCHHH
DLFIGSVIPGLMMASAFALHVLIVAFIRPDVAPALPAQVREIGGKALGKRVIQVMIPPLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LILLVLGSIFFGFATPTEAGAVGCAGAIALAAANGQFTLESLRQVCDTTLRITSMVVFIL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IGSTAFSLVFRGLNGDQFMFDVLANLPGGKIGFLFVSMTTVFLLGFFIDFFEIAFIVIPL
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVPVAQKLGIDLVWYGVILGANLQTSFLTPPFGFALFYLRGVAPPEVTTSDIYRGVIPFI
HHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLQLLVLLLIIIFPGIVSFLPSLGS
HHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]