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The map label for this gene is adhI [H]

Identifier: 17230302

GI number: 17230302

Start: 3419284

End: 3420393

Strand: Reverse

Name: adhI [H]

Synonym: all2810

Alternate gene names: 17230302

Gene position: 3420393-3419284 (Counterclockwise)

Preceding gene: 17230305

Following gene: 17230300

Centisome position: 53.33

GC content: 45.32

Gene sequence:

>1110_bases
GTGGAAGTGAAAGCAGCAATAGCTTACGGCGCGGGTAAGCCGTTGACAATTGAAACCGTTCAACTAGAGGGGCCAAAAGC
TGGGGAAGTATTGGTTGAAGTTAAAGCCAGTGGCGTTTGCCATACCGATGCTTACACCCTTTCAGGAAATGATCCCGAAG
GTTTGTTCCCCGCCATTTTAGGACATGAGGGTGCGGGGGTAGTAGTAGATGTGGGCGCTGGTGTTACCAGTGTCAAACCA
GGGGATCATGTGATTCCTCTCTACACCCCAGAATGTCGCCAATGTGCCTATTGTTTAAGCTTTAAGACTAATCTGTGTCA
AGCTATTCGTGGTACTCAAGGACGTGGTGTGATGCCCGATGGGACTAGTCGTTTTAGTATCAATGGGCAGATGATTCATC
ACTATATGGGTACATCTACGTTTGCTAACTACACAGTGTTACCGGAAATTGCTGTAGCCAAAATTCGAGAAGATGCCCCA
TTTGACAAGGTTTGTTACATTGGGTGCGGTGTAACGACAGGTATTGGTGCAGTCATTTATACAGCCAAGGTGGAAGCAGG
GGCAAATGTCGTCGTTTTTGGCTTGGGGGGTATTGGTTTAAACGTCATCCAAGGGGCGCGGATGGTGGGTGCGAATATGA
TTGTCGGCGTAGATATTAATCCCAGCAAACGCGCCTTGGCTGAAAAATTTGGGATGACACATTTTGTTAATCCCCAAGAA
GTTGAGGGTGATTTAGTTGCTTATTTGGTGGACTTAACGAAAGGCGGCGCTGATTACAGTTTTGAATGTATTGGTAACGT
CAATGTGATGCGCCAAGCCTTAGAATGCTGTCATAAGGGTTGGGGTGTGAGTGTAATTATTGGTGTAGCTGGTGCAGGAC
AAGAAATTAGTACTCGTCCCTTTCAATTAGTGACTGGGCGTGTGTGGAAAGGTTCTGCTTTTGGTGGCGCTAGAGGGCGT
ACAGATGTGCCGAAAATTGTTGATTGGTATATGGATGGAAAGATAAATATTGATGATTTAATTACTCATGTGATGCCAAT
TGAAAAAATTAATGATGCTATGGATTTGATGCACAGAGGTGAATCGATTCGCAGTGTGGTGACTTTTTAA

Upstream 100 bases:

>100_bases
TCATTTTTAATTTTTCAGTGTTGCAGGTAAGATACTCCCAGGTAAGGGCTTTTTTTGAATTTTGAATTTTGAATTTTGAA
TTGATGAGGAGGGCTAACTC

Downstream 100 bases:

>100_bases
TAGCTAGATTGTACTCAGAGTGGGTAATACCCAACTTGATTATATAGAGGCAGGTGCGATCGCTTTACCCCATCTGTCCT
CGTACCCATTCCCTAATTAC

Product: glutathione dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MEVKAAIAYGAGKPLTIETVQLEGPKAGEVLVEVKASGVCHTDAYTLSGNDPEGLFPAILGHEGAGVVVDVGAGVTSVKP
GDHVIPLYTPECRQCAYCLSFKTNLCQAIRGTQGRGVMPDGTSRFSINGQMIHHYMGTSTFANYTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGIGAVIYTAKVEAGANVVVFGLGGIGLNVIQGARMVGANMIVGVDINPSKRALAEKFGMTHFVNPQE
VEGDLVAYLVDLTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEISTRPFQLVTGRVWKGSAFGGARGR
TDVPKIVDWYMDGKINIDDLITHVMPIEKINDAMDLMHRGESIRSVVTF

Sequences:

>Translated_369_residues
MEVKAAIAYGAGKPLTIETVQLEGPKAGEVLVEVKASGVCHTDAYTLSGNDPEGLFPAILGHEGAGVVVDVGAGVTSVKP
GDHVIPLYTPECRQCAYCLSFKTNLCQAIRGTQGRGVMPDGTSRFSINGQMIHHYMGTSTFANYTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGIGAVIYTAKVEAGANVVVFGLGGIGLNVIQGARMVGANMIVGVDINPSKRALAEKFGMTHFVNPQE
VEGDLVAYLVDLTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEISTRPFQLVTGRVWKGSAFGGARGR
TDVPKIVDWYMDGKINIDDLITHVMPIEKINDAMDLMHRGESIRSVVTF
>Mature_369_residues
MEVKAAIAYGAGKPLTIETVQLEGPKAGEVLVEVKASGVCHTDAYTLSGNDPEGLFPAILGHEGAGVVVDVGAGVTSVKP
GDHVIPLYTPECRQCAYCLSFKTNLCQAIRGTQGRGVMPDGTSRFSINGQMIHHYMGTSTFANYTVLPEIAVAKIREDAP
FDKVCYIGCGVTTGIGAVIYTAKVEAGANVVVFGLGGIGLNVIQGARMVGANMIVGVDINPSKRALAEKFGMTHFVNPQE
VEGDLVAYLVDLTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEISTRPFQLVTGRVWKGSAFGGARGR
TDVPKIVDWYMDGKINIDDLITHVMPIEKINDAMDLMHRGESIRSVVTF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=59.9455040871935, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=47.9674796747967, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=46.8834688346883, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=45.1871657754011, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=46.3414634146341, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=44.3243243243243, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=44.3243243243243, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=44.6866485013624, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.8753462603878, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI156627571, Length=368, Percent_Identity=22.8260869565217, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=61.2466124661247, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI87082125, Length=364, Percent_Identity=26.6483516483516, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=25.3561253561254, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.7534246575342, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=26.1363636363636, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081918, Length=222, Percent_Identity=31.0810810810811, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=357, Percent_Identity=24.3697478991597, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786825, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=25.8152173913043, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=57.372654155496, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=57.0666666666667, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=57.566765578635, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562584, Length=374, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=27.4932614555256, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=352, Percent_Identity=26.9886363636364, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=278, Percent_Identity=25.5395683453237, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=54.7683923705722, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319621, Length=365, Percent_Identity=29.8630136986301, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=359, Percent_Identity=27.5766016713092, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=27.8688524590164, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=28.7292817679558, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=28.7292817679558, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=359, Percent_Identity=27.0194986072423, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=28.735632183908, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=373, Percent_Identity=25.201072386059, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=61.9565217391304, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39128; Mature: 39128

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKAAIAYGAGKPLTIETVQLEGPKAGEVLVEVKASGVCHTDAYTLSGNDPEGLFPAIL
CCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVDVGAGVTSVKPGDHVIPLYTPECRQCAYCLSFKTNLCQAIRGTQGRGVMPD
CCCCCCEEEECCCCEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GTSRFSINGQMIHHYMGTSTFANYTVLPEIAVAKIREDAPFDKVCYIGCGVTTGIGAVIY
CCCEEEECCEEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEECCHHHCCCEEEE
TAKVEAGANVVVFGLGGIGLNVIQGARMVGANMIVGVDINPSKRALAEKFGMTHFVNPQE
EEEECCCCCEEEEEECCCCHHHHHCCEEECCEEEEEEECCCHHHHHHHHHCCEECCCHHH
VEGDLVAYLVDLTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEISTRP
CCCHHEEEEEEHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGARGRTDVPKIVDWYMDGKINIDDLITHVMPIEKINDAMDLMHRG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
ESIRSVVTF
HHHHHHHCC
>Mature Secondary Structure
MEVKAAIAYGAGKPLTIETVQLEGPKAGEVLVEVKASGVCHTDAYTLSGNDPEGLFPAIL
CCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVDVGAGVTSVKPGDHVIPLYTPECRQCAYCLSFKTNLCQAIRGTQGRGVMPD
CCCCCCEEEECCCCEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GTSRFSINGQMIHHYMGTSTFANYTVLPEIAVAKIREDAPFDKVCYIGCGVTTGIGAVIY
CCCEEEECCEEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEECCHHHCCCEEEE
TAKVEAGANVVVFGLGGIGLNVIQGARMVGANMIVGVDINPSKRALAEKFGMTHFVNPQE
EEEECCCCCEEEEEECCCCHHHHHCCEEECCEEEEEEECCCHHHHHHHHHCCEECCCHHH
VEGDLVAYLVDLTKGGADYSFECIGNVNVMRQALECCHKGWGVSVIIGVAGAGQEISTRP
CCCHHEEEEEEHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGARGRTDVPKIVDWYMDGKINIDDLITHVMPIEKINDAMDLMHRG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
ESIRSVVTF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]