Click here to switch to the map view.

The map label for this gene is trxA [C]

Identifier: 17229859

GI number: 17229859

Start: 2851152

End: 2851478

Strand: Reverse

Name: trxA [C]

Synonym: all2367

Alternate gene names: 17229859

Gene position: 2851478-2851152 (Counterclockwise)

Preceding gene: 17229860

Following gene: 17229856

Centisome position: 44.46

GC content: 39.76

Gene sequence:

>327_bases
ATGCCTACTGATACAGTTGCTTACGTTCAAGAAAATGAATTTGATACCGTTTTAAGTGAAGATAAAGTCGTTGTAGTTGA
CTTTACTGCTACTTGGTGTGGCCCATGTCGCCTTGTCAGTCCGTTAATGGATCAACTAGCTGATGAGTACAAAGGCCGCG
TTAAAGTGGTTAAGGTAGACGTAGACAACAATAAACCTCTCTTCAAAAGGTTTGGACTTCGCAGTATTCCAGCCGTGTTA
ATTTTTAAAGATGGTGAGTTAACAGAAAAGATTGTGGGAGTTTCTCCTTATGAACAGTTTAGTGGAGCAGTGGAAAAGCT
TATTTAG

Upstream 100 bases:

>100_bases
GTATCTGTGGTGAACAACTAACTGTATCAACACAGAAACAATCATACTTTCATCTTCTTCTGTTTACAAAAATTTTAGTT
TGATATTGGAAATAAAATTA

Downstream 100 bases:

>100_bases
CTTGTTTTTGAGTATTGGTAAAACAAGTGCTGTGGTATTGACCAGGTATTGTTAAAGTTGTTATAGCATTGTTGCAGTGA
GAAATGATTATTAATGAATT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MPTDTVAYVQENEFDTVLSEDKVVVVDFTATWCGPCRLVSPLMDQLADEYKGRVKVVKVDVDNNKPLFKRFGLRSIPAVL
IFKDGELTEKIVGVSPYEQFSGAVEKLI

Sequences:

>Translated_108_residues
MPTDTVAYVQENEFDTVLSEDKVVVVDFTATWCGPCRLVSPLMDQLADEYKGRVKVVKVDVDNNKPLFKRFGLRSIPAVL
IFKDGELTEKIVGVSPYEQFSGAVEKLI
>Mature_107_residues
PTDTVAYVQENEFDTVLSEDKVVVVDFTATWCGPCRLVSPLMDQLADEYKGRVKVVKVDVDNNKPLFKRFGLRSIPAVLI
FKDGELTEKIVGVSPYEQFSGAVEKLI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=35.1063829787234, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI50592994, Length=88, Percent_Identity=32.9545454545455, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=39.3939393939394, Blast_Score=98, Evalue=2e-22,
Organism=Escherichia coli, GI1788936, Length=87, Percent_Identity=42.5287356321839, Blast_Score=86, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509965, Length=101, Percent_Identity=34.6534653465347, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=93, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=85, Percent_Identity=34.1176470588235, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=36.4864864864865, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=96, Percent_Identity=28.125, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=73, Percent_Identity=38.3561643835616, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=37.6470588235294, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=36.4705882352941, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=43.0379746835443, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24664269, Length=101, Percent_Identity=40.5940594059406, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17530795, Length=90, Percent_Identity=31.1111111111111, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639068, Length=83, Percent_Identity=36.144578313253, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=40.2439024390244, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12098; Mature: 11967

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDTVAYVQENEFDTVLSEDKVVVVDFTATWCGPCRLVSPLMDQLADEYKGRVKVVKVD
CCCCCEEEEECCCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDNNKPLFKRFGLRSIPAVLIFKDGELTEKIVGVSPYEQFSGAVEKLI
ECCCCCHHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTDTVAYVQENEFDTVLSEDKVVVVDFTATWCGPCRLVSPLMDQLADEYKGRVKVVKVD
CCCCEEEEECCCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDNNKPLFKRFGLRSIPAVLIFKDGELTEKIVGVSPYEQFSGAVEKLI
ECCCCCHHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]