Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 17229847

GI number: 17229847

Start: 2837152

End: 2838243

Strand: Direct

Name: ald [H]

Synonym: alr2355

Alternate gene names: 17229847

Gene position: 2837152-2838243 (Clockwise)

Preceding gene: 17229843

Following gene: 17229851

Centisome position: 44.24

GC content: 44.69

Gene sequence:

>1092_bases
ATGGAAATCGGCGTTCCTAAAGAAACTAAAGATCAAGAATTTCGTGTGGGGTTAAGTCCTGCTAGCGTGCGGGTGTTGAA
GGAAAATGGTCATAGTATATTTGTTCAGACTCAAGCTGGTAGTGGTGCTGGGTTTACAGATGATGATTATCGCAGTGTAG
GGGCGGATATTGTCCCAACAGCAGAGGCAGTTTGGAGTCGAGAGTTAGTAGTCAAAGTTAAAGAACCACTGACGAGTGAG
TACAACTTTTTACAGAAAGGGCAGATATTGTTTACTTATCTGCATTTAGCAGCCGATCGCAAATTAACAGAGCATTTAAT
TGATTGTGGCATTTGTGCGATCGCTTACGAAACCGTAGAACAACCAGGCGCTAACAGACTACCACTACTGACCCCCATGA
GCATTATTGCCGGTCGGTTAGCAGTACAATTTGGCGCACGCTATTTAGAACGCCAACAAGGTGGTAGAGGTGTACTGCTG
GGTGGTGTTCCTGGAGTTAAACCAGGAAAAGTAGTTATTCTCGGTGGCGGTGTAGTTGGTACAGAAGCTGCCAGAATTGC
CGTAGGTATGGGTGCAACCGTACAAATATTAGATGTAAATGTTGAACGTTTATCTTATTTAGAAACTTTGTTTGGTTCTA
GAGTGGAATTACTTTACAGCAGTTCTGCCCATATCGAAGCCGCAGTTAAAGAAGCAGATTTACTTGTTGGTGCTGTTTTG
GTACTAGGACGCAGAGCGCCAATTCTAGTATCTCGTGAATTAGTTAAACAAATGCACCCAGGTTCGGTAATAGTTGATGT
GGCTGTAGATCAAGGTGGTTGTGTGGAAACCTTACACGCCACATCCCACACCAACCCAACATACCTTGAAGAGGGCGTAG
TACATTACGGCGTTCCCAATATGCCAGGTGCAGTACCTTGGACAGCCACTCAAGCTCTTAACAACAGTACATTGCCTTAC
GTTGTGCAGTTGGCAAATCAAGGACTCAAAGCGTTGGAAGTGAATCAAGTACTCGCCAAGGGTTTGAATGTGCAGAATCA
TCGCCTTGTACACCCGGCTGTACAAGAGGTTTTTCCTGATTTAGTCCATTGA

Upstream 100 bases:

>100_bases
GATTGGGCAAACTAATGTTGTAGATAGATATCCACAATACGGAAGTGTCAGTCTGATACTGGCAGGCTAAATTAAACAAA
AAATTTATCAGAGGCGTTAA

Downstream 100 bases:

>100_bases
TTTTAGGGTAATTGGTAATTGGTAATTGGTAATTGAGAACAAATTCCTTGCCATTACCCATTACCCATTCCCCATTCCCA
ATTTACGTTTTACATCGATT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MEIGVPKETKDQEFRVGLSPASVRVLKENGHSIFVQTQAGSGAGFTDDDYRSVGADIVPTAEAVWSRELVVKVKEPLTSE
YNFLQKGQILFTYLHLAADRKLTEHLIDCGICAIAYETVEQPGANRLPLLTPMSIIAGRLAVQFGARYLERQQGGRGVLL
GGVPGVKPGKVVILGGGVVGTEAARIAVGMGATVQILDVNVERLSYLETLFGSRVELLYSSSAHIEAAVKEADLLVGAVL
VLGRRAPILVSRELVKQMHPGSVIVDVAVDQGGCVETLHATSHTNPTYLEEGVVHYGVPNMPGAVPWTATQALNNSTLPY
VVQLANQGLKALEVNQVLAKGLNVQNHRLVHPAVQEVFPDLVH

Sequences:

>Translated_363_residues
MEIGVPKETKDQEFRVGLSPASVRVLKENGHSIFVQTQAGSGAGFTDDDYRSVGADIVPTAEAVWSRELVVKVKEPLTSE
YNFLQKGQILFTYLHLAADRKLTEHLIDCGICAIAYETVEQPGANRLPLLTPMSIIAGRLAVQFGARYLERQQGGRGVLL
GGVPGVKPGKVVILGGGVVGTEAARIAVGMGATVQILDVNVERLSYLETLFGSRVELLYSSSAHIEAAVKEADLLVGAVL
VLGRRAPILVSRELVKQMHPGSVIVDVAVDQGGCVETLHATSHTNPTYLEEGVVHYGVPNMPGAVPWTATQALNNSTLPY
VVQLANQGLKALEVNQVLAKGLNVQNHRLVHPAVQEVFPDLVH
>Mature_363_residues
MEIGVPKETKDQEFRVGLSPASVRVLKENGHSIFVQTQAGSGAGFTDDDYRSVGADIVPTAEAVWSRELVVKVKEPLTSE
YNFLQKGQILFTYLHLAADRKLTEHLIDCGICAIAYETVEQPGANRLPLLTPMSIIAGRLAVQFGARYLERQQGGRGVLL
GGVPGVKPGKVVILGGGVVGTEAARIAVGMGATVQILDVNVERLSYLETLFGSRVELLYSSSAHIEAAVKEADLLVGAVL
VLGRRAPILVSRELVKQMHPGSVIVDVAVDQGGCVETLHATSHTNPTYLEEGVVHYGVPNMPGAVPWTATQALNNSTLPY
VVQLANQGLKALEVNQVLAKGLNVQNHRLVHPAVQEVFPDLVH

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=343, Percent_Identity=30.9037900874636, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI122939153, Length=343, Percent_Identity=30.9037900874636, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1787887, Length=368, Percent_Identity=29.8913043478261, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17550456, Length=357, Percent_Identity=29.1316526610644, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38894; Mature: 38894

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGVPKETKDQEFRVGLSPASVRVLKENGHSIFVQTQAGSGAGFTDDDYRSVGADIVPT
CCCCCCCCCCCCCEEECCCHHHEEEEEECCCEEEEEEECCCCCCCCCCHHHHCCCCCCCC
AEAVWSRELVVKVKEPLTSEYNFLQKGQILFTYLHLAADRKLTEHLIDCGICAIAYETVE
HHHHHHHHHEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPGANRLPLLTPMSIIAGRLAVQFGARYLERQQGGRGVLLGGVPGVKPGKVVILGGGVVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCEEC
TEAARIAVGMGATVQILDVNVERLSYLETLFGSRVELLYSSSAHIEAAVKEADLLVGAVL
CCHHEEEECCCCEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
VLGRRAPILVSRELVKQMHPGSVIVDVAVDQGGCVETLHATSHTNPTYLEEGVVHYGVPN
HHCCCCCCEEHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHCCCEEECCCC
MPGAVPWTATQALNNSTLPYVVQLANQGLKALEVNQVLAKGLNVQNHRLVHPAVQEVFPD
CCCCCCCHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHHHH
LVH
HCC
>Mature Secondary Structure
MEIGVPKETKDQEFRVGLSPASVRVLKENGHSIFVQTQAGSGAGFTDDDYRSVGADIVPT
CCCCCCCCCCCCCEEECCCHHHEEEEEECCCEEEEEEECCCCCCCCCCHHHHCCCCCCCC
AEAVWSRELVVKVKEPLTSEYNFLQKGQILFTYLHLAADRKLTEHLIDCGICAIAYETVE
HHHHHHHHHEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPGANRLPLLTPMSIIAGRLAVQFGARYLERQQGGRGVLLGGVPGVKPGKVVILGGGVVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCEEC
TEAARIAVGMGATVQILDVNVERLSYLETLFGSRVELLYSSSAHIEAAVKEADLLVGAVL
CCHHEEEECCCCEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
VLGRRAPILVSRELVKQMHPGSVIVDVAVDQGGCVETLHATSHTNPTYLEEGVVHYGVPN
HHCCCCCCEEHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHCCCEEECCCC
MPGAVPWTATQALNNSTLPYVVQLANQGLKALEVNQVLAKGLNVQNHRLVHPAVQEVFPD
CCCCCCCHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHHHH
LVH
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA