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The map label for this gene is lpxB [H]

Identifier: 17229766

GI number: 17229766

Start: 2736581

End: 2737735

Strand: Direct

Name: lpxB [H]

Synonym: alr2274

Alternate gene names: 17229766

Gene position: 2736581-2737735 (Clockwise)

Preceding gene: 17229765

Following gene: 17229768

Centisome position: 42.67

GC content: 44.59

Gene sequence:

>1155_bases
ATGCGGATATTTATTAGCACTGGCGAAGTTTCTGGCGATTTGCAAGGGGCGCTGTTGATTGCGGCGCTGCAACGTCAGGC
TGTGGCTCTGGGGGTGGAGTTAGAGATTGTGGCTCTGGGTGGCGACAAAATGGCGGCTGCTGGGGCAACTATTTTGGGCA
ATACCAGTGGTATTGGTTCAATGGGGATTTTTGAATCTCTGCCCTATGTTGTGCCTACTTTGATAGTACAACGACGAGCG
ATCGCCTATTTAAAACAAAACCCCCCAGATTTAGTAGTGCTGATTGATTACATGGGGCCAAATCTTGGCGTTGGGACTTA
TATGCAGAAGCATTTACCCCATGTGCCTGTAGCCTATTACATCGCGCCCCAAGAGTGGGTTTGGTCGATGAGTTTGCGGA
ATACATCCCGAATAGTTGGTTTTACAGATAAATTATTGGCAATTTTTCCAGAAGAAGCACGTTATTTTAGTCACAACGGT
GCTGATGTTACCTGGGTAGGACATCCTTTAATTGACCGAATGCAGGAGGTTCTTAGCAGAGAAGAAGCTCGCGCAAAGTT
AGGAATTACACCAGAACAAAAAGCGATCGCTCTTTTGCCCGCTTCCCGTAAGCAAGAGTTAAAATATTTACTACCACCAA
TTTTCCAAGCTGCCCAAAATATTCAAGCTAAATTACCAGAGGCGCATTTTTGGATTCCCCTGTCGTTGGAAGTTTACAGA
CAACCAATCGAAGCAGCCATCAAAAGTTACGGTTTACAAGCAACAATTGTATCTGGTCAACAAAAAGAAGTATTTGCGGC
GGCTGATATCGCCATTACCAAATCTGGCACAGTTAATTTAGAACTTGCCCTGTTGAACATACCGCAAGTTGTAGTTTATC
GCTTACATCCTGTCACCGTTTGGATTGCGCGGAAAATCCTTAAAGGTTCTATCCCTTTTGCCTCGCCACCTAATTTAGTG
GTAATGAAACCAATTGTGCCAGAGTTGTTACAAGAACAAGCAACCCCAGAGAATATTACGCAAGCATCGATGGAATTATT
GCTCAATTACGAGCGCCGTAAGCAAACCTTGGCAGACTATCAAGAAATGCGCCAATGTTTGGGAGAATTAGGAGTATGCG
ATCGCGCAGCTCAAGAAATTTTGCAAATGCTTTAG

Upstream 100 bases:

>100_bases
TCAACGATTTTCCCCTTCCCCAGTCCCCAATCCCCAATCCCTAATCCCCAATCCCTAATCCCCAATCCCTAATCCCCAAT
CCCTAATCCCTAATATTAAA

Downstream 100 bases:

>100_bases
AGCGTGCTGGCTCAAGTCGCTTCTCTACAAGATGTTGCGCGTTAATAGCGCAGGCGTAACGCTCCAAATTCAAAATTCAA
AAAAGGTCAATGGTTTGTAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGSMGIFESLPYVVPTLIVQRRA
IAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYYIAPQEWVWSMSLRNTSRIVGFTDKLLAIFPEEARYFSHNG
ADVTWVGHPLIDRMQEVLSREEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLPEAHFWIPLSLEVYR
QPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTVWIARKILKGSIPFASPPNLV
VMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADYQEMRQCLGELGVCDRAAQEILQML

Sequences:

>Translated_384_residues
MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGSMGIFESLPYVVPTLIVQRRA
IAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYYIAPQEWVWSMSLRNTSRIVGFTDKLLAIFPEEARYFSHNG
ADVTWVGHPLIDRMQEVLSREEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLPEAHFWIPLSLEVYR
QPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTVWIARKILKGSIPFASPPNLV
VMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADYQEMRQCLGELGVCDRAAQEILQML
>Mature_384_residues
MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGSMGIFESLPYVVPTLIVQRRA
IAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYYIAPQEWVWSMSLRNTSRIVGFTDKLLAIFPEEARYFSHNG
ADVTWVGHPLIDRMQEVLSREEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLPEAHFWIPLSLEVYR
QPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTVWIARKILKGSIPFASPPNLV
VMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADYQEMRQCLGELGVCDRAAQEILQML

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=385, Percent_Identity=28.3116883116883, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42392; Mature: 42392

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGS
CEEEEECCCCCCCHHHHHHHHHHHHHHHEECEEEEEEEECCCCHHHCCCEEEECCCCCCC
MGIFESLPYVVPTLIVQRRAIAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYY
HHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEE
IAPQEWVWSMSLRNTSRIVGFTDKLLAIFPEEARYFSHNGADVTWVGHPLIDRMQEVLSR
ECCHHHEEEECCCCCCEEECCHHHHHHHCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHH
EEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLPEAHFWIPLSLEVYR
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEHHHHH
QPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTV
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCEEEEEEEECCCCEEEEEECHHHH
WIARKILKGSIPFASPPNLVVMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADY
HHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEMRQCLGELGVCDRAAQEILQML
HHHHHHHHHCCCCHHHHHHHHHHC
>Mature Secondary Structure
MRIFISTGEVSGDLQGALLIAALQRQAVALGVELEIVALGGDKMAAAGATILGNTSGIGS
CEEEEECCCCCCCHHHHHHHHHHHHHHHEECEEEEEEEECCCCHHHCCCEEEECCCCCCC
MGIFESLPYVVPTLIVQRRAIAYLKQNPPDLVVLIDYMGPNLGVGTYMQKHLPHVPVAYY
HHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEE
IAPQEWVWSMSLRNTSRIVGFTDKLLAIFPEEARYFSHNGADVTWVGHPLIDRMQEVLSR
ECCHHHEEEECCCCCCEEECCHHHHHHHCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHH
EEARAKLGITPEQKAIALLPASRKQELKYLLPPIFQAAQNIQAKLPEAHFWIPLSLEVYR
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEHHHHH
QPIEAAIKSYGLQATIVSGQQKEVFAAADIAITKSGTVNLELALLNIPQVVVYRLHPVTV
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCEEEEEEEECCCCEEEEEECHHHH
WIARKILKGSIPFASPPNLVVMKPIVPELLQEQATPENITQASMELLLNYERRKQTLADY
HHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEMRQCLGELGVCDRAAQEILQML
HHHHHHHHHCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA