Click here to switch to the map view.

The map label for this gene is xorIIM [H]

Identifier: 17229768

GI number: 17229768

Start: 2738971

End: 2740266

Strand: Direct

Name: xorIIM [H]

Synonym: alr2276

Alternate gene names: 17229768

Gene position: 2738971-2740266 (Clockwise)

Preceding gene: 17229766

Following gene: 17229770

Centisome position: 42.7

GC content: 43.52

Gene sequence:

>1296_bases
ATGAGTTCCAGCACCCAGGAATTAAAACGCAACTCTAAGCGACGACGACCCATCGCTGTAGATTTGTTTGCAGGTGCAGG
AGGAATGAGTCTTGGTTTTGAACAGGCTGGTTTTGATGTGTTGGCGGCGGTGGAAATTGACCCCATTCACTGTGCAGTAC
ATGAGTATAACTTTCCTTTTTGCTCAGTTTTGTGCAAAAGTGTAGAAGAGACGACAGGCAAAGAGATACGCGATCGCTCC
AAAATCAATAACCAAGAAATAGATGTAATTATTTGCGGTAGTCCCTGTCAAGGTTTTTCCCTGATGGGTAAGCGGGTTTT
TGATGACCCCCGTAACTCCTTAGTATTTCACTTTCATCGGTTAGTACTGGAGTTACAACCGAAATTTTTTGTCATGGAAA
ATGTGCGGGGGATAACTTTTGGTGAACACAAACAAATCCTCCAAGCCTTGATTTATGAGTTTAAAAGCCACGGTTATCAG
GTGGAAGAGAATTATCAAGTTCTCAATGCAGCTCATTATGGAGTACCGCAGGCGCGGGAAAGATTATTTCTTATTGGTGC
AAGGGAAGATGTAAAGTTACCCAAATACCCCAAACCAATTACCAAACCAGCAAAATCAAATAACTCGAAAGCCAGGAATT
TATCTCGTCTGCCACTTTGTCCAAATGTTTGGGAAGCTATTGGCGATTTACCAGAGGTAGAACAATACCCGGAGTTGTTA
ACAAGAGATTGGATAATTGCAGAGTATGGTAAGCCTAGTAATTACGCTGCCGTACTTCGCGGTATTAGTACTTTAGCAGA
TGATTATTCATGCGATCGCCTATTTGATTCGCGTCTTCTCTCTTCTAGTCTCAGAACCAAGCATTCACAAGCAACCATCG
AACGCTTTGCGGCTACAGTCCCAGGGGAAAGAGAACCAATCAGTCGATTCCATAAACTGCATCCATCCGGTGTCTGCAAT
ACCTTAAGGGCGGGAACCGATAAGTTTAAAGGTTCTTTCACCTCCCCTAGACCAATTCATCCATTGACACCCCGATGTAT
TACAGTCCGAGAAGCAGCAAGACTACATTCCTACCCAGACTGGTTTAGATTTCATATCACCAAATGGCATGGTTTTCGCC
AGGTTGGTAACTCTGTACCGCCATTACTAGCAAAAGCAGTCGCCAGGGAGATTATTCGCAGATTGAATATATCACCTGTG
AAACCCAATATTTGCTACCCATTGGGACAAGAAAAGCTACTGCAATTCAACATTTCTCAAGCGGCGCAGTATTATTCTGA
TTTGAAGGGGGTGTAG

Upstream 100 bases:

>100_bases
GTTATAGAATATACTAATTTTAATTTTCCTAAGAATAGTTTAATTAATCGCTGATTCAACAATCTGTATTACGGTTTATC
TTTCAGCGTTTGCATCATCA

Downstream 100 bases:

>100_bases
GGGTGTGGGGGTGTAGGGGAAAGATATCTTTCTTTCATCTATGACTGTGAAACCTGTTTTATCGGGTCTGACTTCTTTAA
CACTAACTCCAACTACGGAA

Product: site-specific DNA-methyltransferase

Products: NA

Alternate protein names: M.XorII; Cytosine-specific methyltransferase XorII [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSSSTQELKRNSKRRRPIAVDLFAGAGGMSLGFEQAGFDVLAAVEIDPIHCAVHEYNFPFCSVLCKSVEETTGKEIRDRS
KINNQEIDVIICGSPCQGFSLMGKRVFDDPRNSLVFHFHRLVLELQPKFFVMENVRGITFGEHKQILQALIYEFKSHGYQ
VEENYQVLNAAHYGVPQARERLFLIGAREDVKLPKYPKPITKPAKSNNSKARNLSRLPLCPNVWEAIGDLPEVEQYPELL
TRDWIIAEYGKPSNYAAVLRGISTLADDYSCDRLFDSRLLSSSLRTKHSQATIERFAATVPGEREPISRFHKLHPSGVCN
TLRAGTDKFKGSFTSPRPIHPLTPRCITVREAARLHSYPDWFRFHITKWHGFRQVGNSVPPLLAKAVAREIIRRLNISPV
KPNICYPLGQEKLLQFNISQAAQYYSDLKGV

Sequences:

>Translated_431_residues
MSSSTQELKRNSKRRRPIAVDLFAGAGGMSLGFEQAGFDVLAAVEIDPIHCAVHEYNFPFCSVLCKSVEETTGKEIRDRS
KINNQEIDVIICGSPCQGFSLMGKRVFDDPRNSLVFHFHRLVLELQPKFFVMENVRGITFGEHKQILQALIYEFKSHGYQ
VEENYQVLNAAHYGVPQARERLFLIGAREDVKLPKYPKPITKPAKSNNSKARNLSRLPLCPNVWEAIGDLPEVEQYPELL
TRDWIIAEYGKPSNYAAVLRGISTLADDYSCDRLFDSRLLSSSLRTKHSQATIERFAATVPGEREPISRFHKLHPSGVCN
TLRAGTDKFKGSFTSPRPIHPLTPRCITVREAARLHSYPDWFRFHITKWHGFRQVGNSVPPLLAKAVAREIIRRLNISPV
KPNICYPLGQEKLLQFNISQAAQYYSDLKGV
>Mature_430_residues
SSSTQELKRNSKRRRPIAVDLFAGAGGMSLGFEQAGFDVLAAVEIDPIHCAVHEYNFPFCSVLCKSVEETTGKEIRDRSK
INNQEIDVIICGSPCQGFSLMGKRVFDDPRNSLVFHFHRLVLELQPKFFVMENVRGITFGEHKQILQALIYEFKSHGYQV
EENYQVLNAAHYGVPQARERLFLIGAREDVKLPKYPKPITKPAKSNNSKARNLSRLPLCPNVWEAIGDLPEVEQYPELLT
RDWIIAEYGKPSNYAAVLRGISTLADDYSCDRLFDSRLLSSSLRTKHSQATIERFAATVPGEREPISRFHKLHPSGVCNT
LRAGTDKFKGSFTSPRPIHPLTPRCITVREAARLHSYPDWFRFHITKWHGFRQVGNSVPPLLAKAVAREIIRRLNISPVK
PNICYPLGQEKLLQFNISQAAQYYSDLKGV

Specific function: This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4503351, Length=461, Percent_Identity=27.3318872017354, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI195927037, Length=461, Percent_Identity=27.3318872017354, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI4758184, Length=192, Percent_Identity=28.6458333333333, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788271, Length=202, Percent_Identity=26.7326732673267, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 48867; Mature: 48735

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00094 C5_MTASE_1 ; PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSTQELKRNSKRRRPIAVDLFAGAGGMSLGFEQAGFDVLAAVEIDPIHCAVHEYNFPF
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCEEEEEEEECCEEEEEECCCCCH
CSVLCKSVEETTGKEIRDRSKINNQEIDVIICGSPCQGFSLMGKRVFDDPRNSLVFHFHR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
LVLELQPKFFVMENVRGITFGEHKQILQALIYEFKSHGYQVEENYQVLNAAHYGVPQARE
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHCCCCHHHC
RLFLIGAREDVKLPKYPKPITKPAKSNNSKARNLSRLPLCPNVWEAIGDLPEVEQYPELL
CEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHH
TRDWIIAEYGKPSNYAAVLRGISTLADDYSCDRLFDSRLLSSSLRTKHSQATIERFAATV
HHCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGEREPISRFHKLHPSGVCNTLRAGTDKFKGSFTSPRPIHPLTPRCITVREAARLHSYPD
CCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
WFRFHITKWHGFRQVGNSVPPLLAKAVAREIIRRLNISPVKPNICYPLGQEKLLQFNISQ
HHEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AAQYYSDLKGV
HHHHHHHHCCC
>Mature Secondary Structure 
SSSTQELKRNSKRRRPIAVDLFAGAGGMSLGFEQAGFDVLAAVEIDPIHCAVHEYNFPF
CCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCEEEEEEEECCEEEEEECCCCCH
CSVLCKSVEETTGKEIRDRSKINNQEIDVIICGSPCQGFSLMGKRVFDDPRNSLVFHFHR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
LVLELQPKFFVMENVRGITFGEHKQILQALIYEFKSHGYQVEENYQVLNAAHYGVPQARE
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHCCCCHHHC
RLFLIGAREDVKLPKYPKPITKPAKSNNSKARNLSRLPLCPNVWEAIGDLPEVEQYPELL
CEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHH
TRDWIIAEYGKPSNYAAVLRGISTLADDYSCDRLFDSRLLSSSLRTKHSQATIERFAATV
HHCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGEREPISRFHKLHPSGVCNTLRAGTDKFKGSFTSPRPIHPLTPRCITVREAARLHSYPD
CCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
WFRFHITKWHGFRQVGNSVPPLLAKAVAREIIRRLNISPVKPNICYPLGQEKLLQFNISQ
HHEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
AAQYYSDLKGV
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8078464 [H]