Click here to switch to the map view.

The map label for this gene is fabZ

Identifier: 17229763

GI number: 17229763

Start: 2734820

End: 2735335

Strand: Direct

Name: fabZ

Synonym: alr2271

Alternate gene names: 17229763

Gene position: 2734820-2735335 (Clockwise)

Preceding gene: 17229762

Following gene: 17229764

Centisome position: 42.64

GC content: 44.19

Gene sequence:

>516_bases
ATGTCAACCCTCTCTGAAGTGAAAGCACCCACATCTACAGAACAACCCGCCACTAATGAGGCGACGACACCACCCGAAAT
TAAAACGACTTTTACATCTGAAGAAATTCAGAAATTATTACCCCACCGCTACCCGTTCTTGCTTGTAGACAAAATTATTG
ACTACACACCAGGAAAACAGGCAGTAGGTATTAAAAATGTCACTATTAACGAGCCACATTTCACCGGTCATTTCCCAGAT
AGACCACTAATGCCAGGAGTACTAATTGTCGAAGCAATGGCTCAAGTAGGTGGTATTGTGATGACGCAACTGCCAGGCTT
AGAAGGTGGTTTATTTGTATTCGCGGGTATTGATAAAGTCCGTTTCCGCCGTCAAGTAGTACCAGGAGACCAACTGGTAA
TGACAGTGGAACTGTTATGGATTAAACAACGTCGTTTCGGTAAAATGCAAGCCCGTGCAGAAGTTGACGGTCAACTAGCA
GCCGAAGGCGAATTAATGTTTTCGCTGATCAACTAG

Upstream 100 bases:

>100_bases
CGAATTTTAGCTTTGAGTAACTAAATTTCGGCTTGGAGCTAAAATTCCTTGTTACACGTACCTACATTCATGACAAGATT
ACAAATTAACCACCTTGCCA

Downstream 100 bases:

>100_bases
CAAATAGCTTTCGTGGTATCGGTACAACCGTGAAGTACTTTTACTCAACCCTGAAACAGGATACCAGTAAAAAAAAATAG
CCACAAGAGCATCTTATAAT

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: NA

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MSTLSEVKAPTSTEQPATNEATTPPEIKTTFTSEEIQKLLPHRYPFLLVDKIIDYTPGKQAVGIKNVTINEPHFTGHFPD
RPLMPGVLIVEAMAQVGGIVMTQLPGLEGGLFVFAGIDKVRFRRQVVPGDQLVMTVELLWIKQRRFGKMQARAEVDGQLA
AEGELMFSLIN

Sequences:

>Translated_171_residues
MSTLSEVKAPTSTEQPATNEATTPPEIKTTFTSEEIQKLLPHRYPFLLVDKIIDYTPGKQAVGIKNVTINEPHFTGHFPD
RPLMPGVLIVEAMAQVGGIVMTQLPGLEGGLFVFAGIDKVRFRRQVVPGDQLVMTVELLWIKQRRFGKMQARAEVDGQLA
AEGELMFSLIN
>Mature_170_residues
STLSEVKAPTSTEQPATNEATTPPEIKTTFTSEEIQKLLPHRYPFLLVDKIIDYTPGKQAVGIKNVTINEPHFTGHFPDR
PLMPGVLIVEAMAQVGGIVMTQLPGLEGGLFVFAGIDKVRFRRQVVPGDQLVMTVELLWIKQRRFGKMQARAEVDGQLAA
EGELMFSLIN

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=142, Percent_Identity=50, Blast_Score=136, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_NOSS1 (Q8YUR4)

Other databases:

- EMBL:   BA000019
- PIR:   AH2089
- RefSeq:   NP_486311.1
- ProteinModelPortal:   Q8YUR4
- SMR:   Q8YUR4
- STRING:   Q8YUR4
- GeneID:   1105868
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr2271
- NMPDR:   fig|103690.1.peg.2578
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   NVSANES
- PhylomeDB:   Q8YUR4
- ProtClustDB:   PRK00006
- BioCyc:   NSP103690:ALR2271-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.-

Molecular weight: Translated: 18931; Mature: 18800

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: ACT_SITE 77-77

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLSEVKAPTSTEQPATNEATTPPEIKTTFTSEEIQKLLPHRYPFLLVDKIIDYTPGKQ
CCCHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCHHHHHHHHCCCCCCC
AVGIKNVTINEPHFTGHFPDRPLMPGVLIVEAMAQVGGIVMTQLPGLEGGLFVFAGIDKV
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCHHH
RFRRQVVPGDQLVMTVELLWIKQRRFGKMQARAEVDGQLAAEGELMFSLIN
HHHHHCCCCCCEEEHHHHHHHHHHHHCHHHHHHCCCCCEECCCEEEEEECC
>Mature Secondary Structure 
STLSEVKAPTSTEQPATNEATTPPEIKTTFTSEEIQKLLPHRYPFLLVDKIIDYTPGKQ
CCHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCHHHHHHHHCCCCCCC
AVGIKNVTINEPHFTGHFPDRPLMPGVLIVEAMAQVGGIVMTQLPGLEGGLFVFAGIDKV
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCHHH
RFRRQVVPGDQLVMTVELLWIKQRRFGKMQARAEVDGQLAAEGELMFSLIN
HHHHHCCCCCCEEEHHHHHHHHHHHHCHHHHHHCCCCCEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840