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The map label for this gene is lpxA [H]

Identifier: 17229764

GI number: 17229764

Start: 2735644

End: 2736402

Strand: Direct

Name: lpxA [H]

Synonym: alr2272

Alternate gene names: 17229764

Gene position: 2735644-2736402 (Clockwise)

Preceding gene: 17229763

Following gene: 17229765

Centisome position: 42.65

GC content: 47.04

Gene sequence:

>759_bases
GTGCAAGTCGGTGCTTATGCTGTGATTGGAGCGCACGTCAAAGTCGGCCCGGAAACAATTATTGGCGCTCATGCTGTGAT
AGAAGGGCCTTGTGAGATTGGGGCGCGAAATCAGATTTTTACAGGTGCAGCTATCGGCATGGAACCGCAGGATCTCAAGT
TTGTGGGAGAACCAACCTGGGTCAAAATTGGCGACAATAACTTGATTCGGGAGTATGTCACCATTAACCGGGCAACTGGA
GCAGGAGAAGCCACAATTATTGGCAATAATAATTTGTTAATGGCTTACACTCACGTAGCTCATAATTGTGTAGTTGAAGA
CTCCGTAGTCATAGCCAACTCTGTCGCTTTGGCTGGTCATGTCCACATCGAATCACGCGCTAGGTTAAGCGGTGTTTTAG
GTGTTCATCAATTCGTACGTATTGGTAGACAGGCAATGGTAGGTGGAATGGCACGAATTGACCGTGATGTACCGCCATAT
ATGTTGGTAGAAGGTAATCCAGGCAGGATTAGAACCCTCAATTTGGTGGGACTCAAGCGCTCTGGTATGGAAGCCAGCGA
CCTGCAACTGCTCAAAAAAGCTTTTCGTATCCTTTACCGTTCTAACTTGCTCTTTAAAGAAGCATTAGAAGAGTTGGAAA
CCTTAGGTGATACAGAACACTTACAACACCTGCGCCGCTTCCTATTGCTATCACAAATGCCAGGAAGACGGGGCTTAATT
CCCGGCAGAGGAAAATCGGGTGGGAGTGATGAATCATAG

Upstream 100 bases:

>100_bases
CAAAGCACTGGCTCCTCAAGACAGTTCTGGAGATTCACCCTTGAAGACGCTTATTCATCCAACTGCTGTAATTCATCCAA
ATTCGGAACTGCACCCAACG

Downstream 100 bases:

>100_bases
GCAGGAGGTAGGAAGCAGAGGAGCCGGGTGGCAGGGGGCAGGGGGCAGGGGAGCAGGGGAGCAGAGGAGAGAAGTTACTC
AACGATTTTCCCCTTCCCCA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQVGAYAVIGAHVKVGPETIIGAHAVIEGPCEIGARNQIFTGAAIGMEPQDLKFVGEPTWVKIGDNNLIREYVTINRATG
AGEATIIGNNNLLMAYTHVAHNCVVEDSVVIANSVALAGHVHIESRARLSGVLGVHQFVRIGRQAMVGGMARIDRDVPPY
MLVEGNPGRIRTLNLVGLKRSGMEASDLQLLKKAFRILYRSNLLFKEALEELETLGDTEHLQHLRRFLLLSQMPGRRGLI
PGRGKSGGSDES

Sequences:

>Translated_252_residues
MQVGAYAVIGAHVKVGPETIIGAHAVIEGPCEIGARNQIFTGAAIGMEPQDLKFVGEPTWVKIGDNNLIREYVTINRATG
AGEATIIGNNNLLMAYTHVAHNCVVEDSVVIANSVALAGHVHIESRARLSGVLGVHQFVRIGRQAMVGGMARIDRDVPPY
MLVEGNPGRIRTLNLVGLKRSGMEASDLQLLKKAFRILYRSNLLFKEALEELETLGDTEHLQHLRRFLLLSQMPGRRGLI
PGRGKSGGSDES
>Mature_252_residues
MQVGAYAVIGAHVKVGPETIIGAHAVIEGPCEIGARNQIFTGAAIGMEPQDLKFVGEPTWVKIGDNNLIREYVTINRATG
AGEATIIGNNNLLMAYTHVAHNCVVEDSVVIANSVALAGHVHIESRARLSGVLGVHQFVRIGRQAMVGGMARIDRDVPPY
MLVEGNPGRIRTLNLVGLKRSGMEASDLQLLKKAFRILYRSNLLFKEALEELETLGDTEHLQHLRRFLLLSQMPGRRGLI
PGRGKSGGSDES

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=218, Percent_Identity=40.8256880733945, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27288; Mature: 27288

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVGAYAVIGAHVKVGPETIIGAHAVIEGPCEIGARNQIFTGAAIGMEPQDLKFVGEPTW
CCCCCEEEEECEEEECCHHHEECHHEEECCCCCCCCCCEEECEECCCCCCCCEEECCCCE
VKIGDNNLIREYVTINRATGAGEATIIGNNNLLMAYTHVAHNCVVEDSVVIANSVALAGH
EEECCCCCEEEEEEEECCCCCCCEEEEECCCEEEEEEHHHHCEEECCCEEEEECEEEEEE
VHIESRARLSGVLGVHQFVRIGRQAMVGGMARIDRDVPPYMLVEGNPGRIRTLNLVGLKR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECC
SGMEASDLQLLKKAFRILYRSNLLFKEALEELETLGDTEHLQHLRRFLLLSQMPGRRGLI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
PGRGKSGGSDES
CCCCCCCCCCCC
>Mature Secondary Structure
MQVGAYAVIGAHVKVGPETIIGAHAVIEGPCEIGARNQIFTGAAIGMEPQDLKFVGEPTW
CCCCCEEEEECEEEECCHHHEECHHEEECCCCCCCCCCEEECEECCCCCCCCEEECCCCE
VKIGDNNLIREYVTINRATGAGEATIIGNNNLLMAYTHVAHNCVVEDSVVIANSVALAGH
EEECCCCCEEEEEEEECCCCCCCEEEEECCCEEEEEEHHHHCEEECCCEEEEECEEEEEE
VHIESRARLSGVLGVHQFVRIGRQAMVGGMARIDRDVPPYMLVEGNPGRIRTLNLVGLKR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECC
SGMEASDLQLLKKAFRILYRSNLLFKEALEELETLGDTEHLQHLRRFLLLSQMPGRRGLI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
PGRGKSGGSDES
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA