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The map label for this gene is lpxC [H]

Identifier: 17229762

GI number: 17229762

Start: 2733901

End: 2734743

Strand: Direct

Name: lpxC [H]

Synonym: alr2270

Alternate gene names: 17229762

Gene position: 2733901-2734743 (Clockwise)

Preceding gene: 17229761

Following gene: 17229763

Centisome position: 42.63

GC content: 46.38

Gene sequence:

>843_bases
ATGAAACAGCACACTCTGGCAGAGGCGATCGCTCACACTGGAGTAGGGCTGCATAGTGGTGTCAGTACCCATGTACGCAT
ACTACCTGCTGATGCGGGTAGTGGTCGTTACTTCGTGCGGGTGGATTTGCCAGACTCCCCAACTATTCCAGCCCAAGTGG
CGGTAGTGAGTCAAACTGTTCTCTCCACTCAGTTGGGTGGAGGTGAAACAGGTGTGCGTACAGTCGAGCATTTATTAGCA
GCCCTGGCGGGGATGGGTGTAGATAACGCCCGTATTGAAATTGATGGCCCAGAAATCCCGCTTTTAGATGGTTCAGCCCA
GGAATGGGTAACGAGCATTGCTGAAGTTGGCTTAGTAGCCCAAGCAGTGACAAACAATCTAGCTTCCTTTGATATCCAAG
AACCAATTTGGATTCATCAAGACGACGCTTTTGTAGCTGCTATCCCGGCATCCGAAACCCGCTTTAGTTACGGCATTGAC
TTTGACTTACCAGCCATTGGTAATCAATGGTACAGTTGGTCACTCACTACCGAGCCAGATACTAGCTTCGCTCAAGAAAT
TGCCCCTGCTCGTACTTTTGGTTTATTACATCAAATCGAATATTTACAAAAGTCTGGGTTAATCAAAGGTGGTAGTTTGG
ATAATGCCCTTATTTGTGGCCCCGATGGCTGGGTAAATCCACCATTAAGATTTGCAAATGAGCCAGTACGTCATAAAATC
TTGGATCTAGTAGGAGATTTGAGTTTACTGGGATATTTTCCCCGCGCTCATTTTCTAGCGTATAAAGCCAGCCATAATTT
ACACATTCAACTGGCACAGCGAATTTTAGCTTTGAGTAACTAA

Upstream 100 bases:

>100_bases
GGTTTTAGGTTGCTTAACTGTTAACGGCTACGGATTTTCAGGGTGTTTACCAAAGATGAATTATGAATAACAAAAATCTC
TATATACTGGCTGTATTCGT

Downstream 100 bases:

>100_bases
ATTTCGGCTTGGAGCTAAAATTCCTTGTTACACGTACCTACATTCATGACAAGATTACAAATTAACCACCTTGCCAATGT
CAACCCTCTCTGAAGTGAAA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTVLSTQLGGGETGVRTVEHLLA
ALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVAQAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGID
FDLPAIGNQWYSWSLTTEPDTSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKI
LDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN

Sequences:

>Translated_280_residues
MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTVLSTQLGGGETGVRTVEHLLA
ALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVAQAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGID
FDLPAIGNQWYSWSLTTEPDTSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKI
LDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN
>Mature_280_residues
MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTVLSTQLGGGETGVRTVEHLLA
ALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVAQAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGID
FDLPAIGNQWYSWSLTTEPDTSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKI
LDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=281, Percent_Identity=38.0782918149466, Blast_Score=179, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30138; Mature: 30138

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTV
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
LSTQLGGGETGVRTVEHLLAALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVA
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHH
QAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGIDFDLPAIGNQWYSWSLTTEPD
HHHHCCHHCCCCCCCEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEECCCC
TSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCCHHHCCCHHHHHH
LDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN
HHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKQHTLAEAIAHTGVGLHSGVSTHVRILPADAGSGRYFVRVDLPDSPTIPAQVAVVSQTV
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
LSTQLGGGETGVRTVEHLLAALAGMGVDNARIEIDGPEIPLLDGSAQEWVTSIAEVGLVA
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHH
QAVTNNLASFDIQEPIWIHQDDAFVAAIPASETRFSYGIDFDLPAIGNQWYSWSLTTEPD
HHHHCCHHCCCCCCCEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEECCCC
TSFAQEIAPARTFGLLHQIEYLQKSGLIKGGSLDNALICGPDGWVNPPLRFANEPVRHKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCCHHHCCCHHHHHH
LDLVGDLSLLGYFPRAHFLAYKASHNLHIQLAQRILALSN
HHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA