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The map label for this gene is purC [H]

Identifier: 17229760

GI number: 17229760

Start: 2730420

End: 2731157

Strand: Direct

Name: purC [H]

Synonym: alr2268

Alternate gene names: 17229760

Gene position: 2730420-2731157 (Clockwise)

Preceding gene: 17229758

Following gene: 17229761

Centisome position: 42.57

GC content: 42.95

Gene sequence:

>738_bases
ATGTCTGTTCATTCCAAGCTATACGAAGGCAAAGCTAAAATTCTCTATACTACCGACGAGCCAGAAGTCTTGCTGGCTGA
TTTTAAAGATGATGCCACTGCCTTTAACGCGCAAAAGCGCGGCAGTATCATTGGCAAAGGCAGAATAAATTGTAGTATTT
CCAGCCAGCTTTTTCAGCAGTTGGAAGCATCTGGGATCAAGACGCACTTTATTGATAGCCCTGCACCCAATCAAATGCGG
GTGAAAGCCGTAAAAATCATACCGCTAGAAGTAGTAATACGTAATATTGCTGCTGGTAGCTTATCTCAGCAAACAGGTAT
AGAGCTAGGTACAGTCTTAAAACAGCCCCTAGTAGAGTTTTATTATAAAAACGATCAGTTAGGAGATCCACTATTAACAC
GCGATCGCCTGCTGTTAATGGAACTAGCCACGGCGGAACAAGTAGAGGAAATTACTCATCTAGCATTGCAAATAAACGAT
TTCCTCAAAAACTTCTGGCAGAATTGCGGTATCACCCTAGTAGACTTCAAACTAGAATTCGGTTTGGACTCACAACAGCA
AATACTCCTGGCTGATGAAATTAGCCCTGATACCTGCCGTTTGTGGAACACAACAGAAGCCGACCCCAATCGCCGCGTTA
TGGATAAAGACCGTTTCCGGCGCGACCTGGGAAATGTAGAAGATGCTTATCAGGAGGTTTTACAAAGAGTACTAACAGCA
GTAGAAATTAAAAATTAG

Upstream 100 bases:

>100_bases
CACTGACTACAGACGAATAGCTAATCGTGAATAACTAAAGATAAAATGGTGAAGCCCGAAAGGACAAAAGCTGCTCATCG
CTCAAACTTTACCTCCCACC

Downstream 100 bases:

>100_bases
ATGTATCAGGAATAATTTTTGATTATTGCAAAACAAACAAGTATATTTGTTTTTTTACCTTTGGCATAAACAAGCAATTG
CCTGGTAATGGTGTGTGGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSVHSKLYEGKAKILYTTDEPEVLLADFKDDATAFNAQKRGSIIGKGRINCSISSQLFQQLEASGIKTHFIDSPAPNQMR
VKAVKIIPLEVVIRNIAAGSLSQQTGIELGTVLKQPLVEFYYKNDQLGDPLLTRDRLLLMELATAEQVEEITHLALQIND
FLKNFWQNCGITLVDFKLEFGLDSQQQILLADEISPDTCRLWNTTEADPNRRVMDKDRFRRDLGNVEDAYQEVLQRVLTA
VEIKN

Sequences:

>Translated_245_residues
MSVHSKLYEGKAKILYTTDEPEVLLADFKDDATAFNAQKRGSIIGKGRINCSISSQLFQQLEASGIKTHFIDSPAPNQMR
VKAVKIIPLEVVIRNIAAGSLSQQTGIELGTVLKQPLVEFYYKNDQLGDPLLTRDRLLLMELATAEQVEEITHLALQIND
FLKNFWQNCGITLVDFKLEFGLDSQQQILLADEISPDTCRLWNTTEADPNRRVMDKDRFRRDLGNVEDAYQEVLQRVLTA
VEIKN
>Mature_244_residues
SVHSKLYEGKAKILYTTDEPEVLLADFKDDATAFNAQKRGSIIGKGRINCSISSQLFQQLEASGIKTHFIDSPAPNQMRV
KAVKIIPLEVVIRNIAAGSLSQQTGIELGTVLKQPLVEFYYKNDQLGDPLLTRDRLLLMELATAEQVEEITHLALQINDF
LKNFWQNCGITLVDFKLEFGLDSQQQILLADEISPDTCRLWNTTEADPNRRVMDKDRFRRDLGNVEDAYQEVLQRVLTAV
EIKN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=248, Percent_Identity=33.8709677419355, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI5453539, Length=248, Percent_Identity=33.8709677419355, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI119220559, Length=262, Percent_Identity=32.0610687022901, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=35.4430379746835, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531275, Length=246, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI18860083, Length=238, Percent_Identity=27.3109243697479, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583917, Length=246, Percent_Identity=28.8617886178862, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27740; Mature: 27609

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHSKLYEGKAKILYTTDEPEVLLADFKDDATAFNAQKRGSIIGKGRINCSISSQLFQQ
CCCHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHCHHHCCCEEECCEEEEEHHHHHHHH
LEASGIKTHFIDSPAPNQMRVKAVKIIPLEVVIRNIAAGSLSQQTGIELGTVLKQPLVEF
HHHCCCEEEECCCCCCCCEEEEEEEEEHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
YYKNDQLGDPLLTRDRLLLMELATAEQVEEITHLALQINDFLKNFWQNCGITLVDFKLEF
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GLDSQQQILLADEISPDTCRLWNTTEADPNRRVMDKDRFRRDLGNVEDAYQEVLQRVLTA
CCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
VEIKN
HHCCC
>Mature Secondary Structure 
SVHSKLYEGKAKILYTTDEPEVLLADFKDDATAFNAQKRGSIIGKGRINCSISSQLFQQ
CCHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHCHHHCCCEEECCEEEEEHHHHHHHH
LEASGIKTHFIDSPAPNQMRVKAVKIIPLEVVIRNIAAGSLSQQTGIELGTVLKQPLVEF
HHHCCCEEEECCCCCCCCEEEEEEEEEHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
YYKNDQLGDPLLTRDRLLLMELATAEQVEEITHLALQINDFLKNFWQNCGITLVDFKLEF
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GLDSQQQILLADEISPDTCRLWNTTEADPNRRVMDKDRFRRDLGNVEDAYQEVLQRVLTA
CCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
VEIKN
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA