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The map label for this gene is tcmP [H]

Identifier: 17229646

GI number: 17229646

Start: 2586680

End: 2587543

Strand: Direct

Name: tcmP [H]

Synonym: alr2154

Alternate gene names: 17229646

Gene position: 2586680-2587543 (Clockwise)

Preceding gene: 17229645

Following gene: 17229647

Centisome position: 40.33

GC content: 36.57

Gene sequence:

>864_bases
ATGAACACACAAAAAGAATCGACAACAAAACTTGTGGGTGTACCTGAAACATTAATGATTACCCTCTACGGACGTTATGT
CGAGCAGGAATTTTCTGACTGTATTCTGGAAGATAAAAAGGCAGTAGAAATTGTCGGAAAAGTTGATTATGACTTCTCTA
AATATTCTAGTTCCTGGTCATCTCAACTAGGTGTTGTCATCCGAGCCAAAAATATCGATGAAATATTAAGACAATTTTTG
ATCACCCATCCACAAGCTACAGTTATTAACTTGGGAGGGGGACTGTGTACAAGATTTTTCCGAGTTGACAATGGGGAGAT
GAACTGGTACGAAATAGATTTCCCCGAAGTTATCGACCTGAAAAGAAAACTGATCTCTGAAAGCGATCGCTATCATTTAA
TTGGTAGTTCTATTCTCGAATCTAGTTGGATATCCCAAATCACACCAGCAACAAATCAGCCTCTATTTATCATCATGGAA
GGCGTATCAATGTATTTAAGCGAGGAGGAAAACCAAAGTGTATTTCGAAAAATTAAAACAATGCTAGCTCCTAAATTTAT
TTCTGTAGAAATGGTATTTGATGTGCTAGATAAAAAAGGAGTAGCTAATACTAAAAAACACGAAACTGTATCCAAAACCG
ATGCGGATTTTAAATGGGGACTAGATAATTTCCATGAAATAGAAGCATGGGATTTATCCATTCAACTCAAAAAAGAAATT
TGTTATCTACCCCAATTCGTCAACTATCCCCATCGCCTGAAACCGTTTTGGTTGAAATACATTTCATTTATGCTAGTACC
CTTATTTAAAAATAGATGCCGCATTCTTCATATCAATCTGACACCCGGATCGCCACTTTCATAA

Upstream 100 bases:

>100_bases
ACCAGGTATTAGTTTAGTTGCAGGTTTAACAGTGAGATTTTAAAGCATCAGCAATAAAACATCAATACGAACAGTAGTTA
ATGTAAATAGACAATTGCTT

Downstream 100 bases:

>100_bases
TTATATGAGTAAGGGTGACATGAAGAGATGTTAGGGATTACACTAAAGGAAACAAGACTTTACCATGAAATTAAGGAAGA
AGGAGAAAAATCCCTTGTTC

Product: tetracenomycin C synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNTQKESTTKLVGVPETLMITLYGRYVEQEFSDCILEDKKAVEIVGKVDYDFSKYSSSWSSQLGVVIRAKNIDEILRQFL
ITHPQATVINLGGGLCTRFFRVDNGEMNWYEIDFPEVIDLKRKLISESDRYHLIGSSILESSWISQITPATNQPLFIIME
GVSMYLSEEENQSVFRKIKTMLAPKFISVEMVFDVLDKKGVANTKKHETVSKTDADFKWGLDNFHEIEAWDLSIQLKKEI
CYLPQFVNYPHRLKPFWLKYISFMLVPLFKNRCRILHINLTPGSPLS

Sequences:

>Translated_287_residues
MNTQKESTTKLVGVPETLMITLYGRYVEQEFSDCILEDKKAVEIVGKVDYDFSKYSSSWSSQLGVVIRAKNIDEILRQFL
ITHPQATVINLGGGLCTRFFRVDNGEMNWYEIDFPEVIDLKRKLISESDRYHLIGSSILESSWISQITPATNQPLFIIME
GVSMYLSEEENQSVFRKIKTMLAPKFISVEMVFDVLDKKGVANTKKHETVSKTDADFKWGLDNFHEIEAWDLSIQLKKEI
CYLPQFVNYPHRLKPFWLKYISFMLVPLFKNRCRILHINLTPGSPLS
>Mature_287_residues
MNTQKESTTKLVGVPETLMITLYGRYVEQEFSDCILEDKKAVEIVGKVDYDFSKYSSSWSSQLGVVIRAKNIDEILRQFL
ITHPQATVINLGGGLCTRFFRVDNGEMNWYEIDFPEVIDLKRKLISESDRYHLIGSSILESSWISQITPATNQPLFIIME
GVSMYLSEEENQSVFRKIKTMLAPKFISVEMVFDVLDKKGVANTKKHETVSKTDADFKWGLDNFHEIEAWDLSIQLKKEI
CYLPQFVNYPHRLKPFWLKYISFMLVPLFKNRCRILHINLTPGSPLS

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: COG3315

COG function: function code Q; O-Methyltransferase involved in polyketide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 33224; Mature: 33224

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQKESTTKLVGVPETLMITLYGRYVEQEFSDCILEDKKAVEIVGKVDYDFSKYSSSWS
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCC
SQLGVVIRAKNIDEILRQFLITHPQATVINLGGGLCTRFFRVDNGEMNWYEIDFPEVIDL
CCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHEEEECCCCCCEEECCCHHHHHH
KRKLISESDRYHLIGSSILESSWISQITPATNQPLFIIMEGVSMYLSEEENQSVFRKIKT
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHH
MLAPKFISVEMVFDVLDKKGVANTKKHETVSKTDADFKWGLDNFHEIEAWDLSIQLKKEI
HHCCCHHHHHHHHHHHHCCCCCCCCHHCHHCCCCCCCCCCCCCCCCCEEEEEEEEEHHHH
CYLPQFVNYPHRLKPFWLKYISFMLVPLFKNRCRILHINLTPGSPLS
HHCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MNTQKESTTKLVGVPETLMITLYGRYVEQEFSDCILEDKKAVEIVGKVDYDFSKYSSSWS
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCC
SQLGVVIRAKNIDEILRQFLITHPQATVINLGGGLCTRFFRVDNGEMNWYEIDFPEVIDL
CCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHEEEECCCCCCEEECCCHHHHHH
KRKLISESDRYHLIGSSILESSWISQITPATNQPLFIIMEGVSMYLSEEENQSVFRKIKT
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHH
MLAPKFISVEMVFDVLDKKGVANTKKHETVSKTDADFKWGLDNFHEIEAWDLSIQLKKEI
HHCCCHHHHHHHHHHHHCCCCCCCCHHCHHCCCCCCCCCCCCCCCCCEEEEEEEEEHHHH
CYLPQFVNYPHRLKPFWLKYISFMLVPLFKNRCRILHINLTPGSPLS
HHCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]