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The map label for this gene is yjcE [H]

Identifier: 17229605

GI number: 17229605

Start: 2529121

End: 2530674

Strand: Reverse

Name: yjcE [H]

Synonym: all2113

Alternate gene names: 17229605

Gene position: 2530674-2529121 (Counterclockwise)

Preceding gene: 17229607

Following gene: 17229602

Centisome position: 39.46

GC content: 43.44

Gene sequence:

>1554_bases
GTGAATATTACCGAATTAATCAAGATTTCTATTATTCTCTTACTCGTTGCCACAGGTGTAGCGTTGCTATCCCGGCGATT
GCGAGTTCCTTATGTCACAGGATTAGTATTAGCAGGTTTGCCTATAACTGAACTCTTGTCTCGTCCCATTGGTTTAGACC
CGGCGCTGGTTTTAAATCTTTTCCTGCCTATTCTCATCTTTGAAGCCGGTATCAATACAGATATCAGCCGCTTACGTAGT
ACATTCAAACCAATTGCCCTGCTGGCAGGGCCAGGGGCTATACTTTCCAGTGCTATTATCGCCATCTTGTTAAAATTTGG
GCTGGGATTGAATTGGATACCGGCTTTCCTTGTAGGAGTAATTCTGGCAAACACAGATACAGTTTCCATGATTGCCGTAT
TTAAGGAAATACCAGTACCTTCCCGCCTTTCTACCATTGTTGAAGGAGAAACTTTATTTAACGATGCTGCGGCCTTAGTT
TCCTTTAATCTAATTTTGCAAGTATATTCGACTGGTTCGCTCACGTTAATAGAGGGAATCCAACAACTGCTATTTATTTC
CGTGGGTGGCTGCCTTGTTGGCTTAGTCTTAGGCTACTTGAGCATACCTGTATTTAACCGTTTAGATGATCCCCTGAGCA
GTCTACTGCTGACTGTGGCAGTTGCCTTAGGAACTTTTCAGGTTGGACAATTTTTAGGCGTATCCGGCGCTGTAGCTGTA
GTTGTTGCTGGGTTAATTTTTGGAAATTTTGGGCTGTCTGGCAATACTTCTGCTTCCAGTCGCATTACCTTATTGAGTTT
TTGGGAATATGCCAGTTTTACTGCTAACACCTTTATTTTTCTGCTGATTGGTGTAGAAATCAACCTAGTAACTCTCTGGC
AAACTTTGCCTGCAATTCTACTGGCAGTTTTGGCTTATCAAGTCGGGCGAGTTTTGACAATCTATCCTTTGCTAGCAGGG
GTTCGCTGGTTTGACAGGCCGATTCCACTACGCTGGCAACACTTACTGTTTTTAGGCAACATTAAAGGTTCACTCTCAAT
GGCTTTGGCGTTAAGTTTACCTACCACACTGCCAGGACGCGAAAGTCTGATTGCTATAGTCTTCGGCTGTGTTCTAGTGT
CGTTGGTGGGACAGGGGTTAAGCTTGCCATTCTTAGTAAAACGTTTAAAATTATCCAAATTTTCACACTCACAGCAACAG
GTTGAAGAATTACAAGCCCAACTAATCACAGCCAAAGCCGCACAAGACGAATTAGATGCCCTCTTGAAAACGGGAGTGTT
ACCAAAAGCTGTATATGAGGAAATGCGTTCAGCTTACCAAGTACAAGTAGCAGGCGCAGAAAAAGCTTTACGAGAGTTCT
ATAATCGCCGCCCAGATGAGTTTGATCATAAAAGTGGCGCATTTAGCAAACTTGACGCTATCCGCCGTCGTTTACTACTA
GCAGAAAAAGGCGCGCTCACAGAAGCAATGCGTAAACGCATTCTCTCCCAAGATATTGGGCAGAATCGGATACAAACGAT
TAATGAAAAGTTGCTGCAACTGGACGATGATTAA

Upstream 100 bases:

>100_bases
ATTGATAACTTTATGCAAGCCTCTCATCCTTTGGGATGTGTTCAAACTGGCTGTATCCTCCAAAAATTGATTGAACACCA
TATAAATTCTGCATATCTTC

Downstream 100 bases:

>100_bases
TGGTTTAGGACTTACGCACCGAGATTTTCTGTTGAGACCGGGTGTAAGGGTGTAGGGGTGTAAGGGTTTCAAACATTTAT
ACCCCTACACCCCTATACCC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNITELIKISIILLLVATGVALLSRRLRVPYVTGLVLAGLPITELLSRPIGLDPALVLNLFLPILIFEAGINTDISRLRS
TFKPIALLAGPGAILSSAIIAILLKFGLGLNWIPAFLVGVILANTDTVSMIAVFKEIPVPSRLSTIVEGETLFNDAAALV
SFNLILQVYSTGSLTLIEGIQQLLFISVGGCLVGLVLGYLSIPVFNRLDDPLSSLLLTVAVALGTFQVGQFLGVSGAVAV
VVAGLIFGNFGLSGNTSASSRITLLSFWEYASFTANTFIFLLIGVEINLVTLWQTLPAILLAVLAYQVGRVLTIYPLLAG
VRWFDRPIPLRWQHLLFLGNIKGSLSMALALSLPTTLPGRESLIAIVFGCVLVSLVGQGLSLPFLVKRLKLSKFSHSQQQ
VEELQAQLITAKAAQDELDALLKTGVLPKAVYEEMRSAYQVQVAGAEKALREFYNRRPDEFDHKSGAFSKLDAIRRRLLL
AEKGALTEAMRKRILSQDIGQNRIQTINEKLLQLDDD

Sequences:

>Translated_517_residues
MNITELIKISIILLLVATGVALLSRRLRVPYVTGLVLAGLPITELLSRPIGLDPALVLNLFLPILIFEAGINTDISRLRS
TFKPIALLAGPGAILSSAIIAILLKFGLGLNWIPAFLVGVILANTDTVSMIAVFKEIPVPSRLSTIVEGETLFNDAAALV
SFNLILQVYSTGSLTLIEGIQQLLFISVGGCLVGLVLGYLSIPVFNRLDDPLSSLLLTVAVALGTFQVGQFLGVSGAVAV
VVAGLIFGNFGLSGNTSASSRITLLSFWEYASFTANTFIFLLIGVEINLVTLWQTLPAILLAVLAYQVGRVLTIYPLLAG
VRWFDRPIPLRWQHLLFLGNIKGSLSMALALSLPTTLPGRESLIAIVFGCVLVSLVGQGLSLPFLVKRLKLSKFSHSQQQ
VEELQAQLITAKAAQDELDALLKTGVLPKAVYEEMRSAYQVQVAGAEKALREFYNRRPDEFDHKSGAFSKLDAIRRRLLL
AEKGALTEAMRKRILSQDIGQNRIQTINEKLLQLDDD
>Mature_517_residues
MNITELIKISIILLLVATGVALLSRRLRVPYVTGLVLAGLPITELLSRPIGLDPALVLNLFLPILIFEAGINTDISRLRS
TFKPIALLAGPGAILSSAIIAILLKFGLGLNWIPAFLVGVILANTDTVSMIAVFKEIPVPSRLSTIVEGETLFNDAAALV
SFNLILQVYSTGSLTLIEGIQQLLFISVGGCLVGLVLGYLSIPVFNRLDDPLSSLLLTVAVALGTFQVGQFLGVSGAVAV
VVAGLIFGNFGLSGNTSASSRITLLSFWEYASFTANTFIFLLIGVEINLVTLWQTLPAILLAVLAYQVGRVLTIYPLLAG
VRWFDRPIPLRWQHLLFLGNIKGSLSMALALSLPTTLPGRESLIAIVFGCVLVSLVGQGLSLPFLVKRLKLSKFSHSQQQ
VEELQAQLITAKAAQDELDALLKTGVLPKAVYEEMRSAYQVQVAGAEKALREFYNRRPDEFDHKSGAFSKLDAIRRRLLL
AEKGALTEAMRKRILSQDIGQNRIQTINEKLLQLDDD

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=392, Percent_Identity=24.7448979591837, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI14211919, Length=398, Percent_Identity=24.6231155778894, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI15529998, Length=384, Percent_Identity=25.2604166666667, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI27734935, Length=338, Percent_Identity=24.5562130177515, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4759144, Length=300, Percent_Identity=27.6666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI294997330, Length=335, Percent_Identity=24.4776119402985, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI110227626, Length=333, Percent_Identity=24.024024024024, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194239733, Length=301, Percent_Identity=25.2491694352159, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI5454070, Length=342, Percent_Identity=23.9766081871345, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI41872703, Length=475, Percent_Identity=22.1052631578947, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI56786136, Length=501, Percent_Identity=22.9540918163673, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=426, Percent_Identity=26.7605633802817, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71992107, Length=397, Percent_Identity=24.6851385390428, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71992101, Length=397, Percent_Identity=24.6851385390428, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=377, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=364, Percent_Identity=25.5494505494505, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993582, Length=364, Percent_Identity=25.5494505494505, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=311, Percent_Identity=23.7942122186495, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25150332, Length=370, Percent_Identity=22.972972972973, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=382, Percent_Identity=21.9895287958115, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=385, Percent_Identity=22.3376623376623, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=366, Percent_Identity=21.0382513661202, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71999817, Length=366, Percent_Identity=21.0382513661202, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=366, Percent_Identity=21.0382513661202, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=359, Percent_Identity=24.5125348189415, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281364513, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221473212, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221473215, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221473222, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221510738, Length=375, Percent_Identity=24, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221510734, Length=375, Percent_Identity=24.2666666666667, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281360447, Length=354, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221510732, Length=375, Percent_Identity=24, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510736, Length=375, Percent_Identity=24, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510740, Length=375, Percent_Identity=24, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585580, Length=375, Percent_Identity=24, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585578, Length=375, Percent_Identity=24, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56050; Mature: 56050

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITELIKISIILLLVATGVALLSRRLRVPYVTGLVLAGLPITELLSRPIGLDPALVLNL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCCHHHHHHH
FLPILIFEAGINTDISRLRSTFKPIALLAGPGAILSSAIIAILLKFGLGLNWIPAFLVGV
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ILANTDTVSMIAVFKEIPVPSRLSTIVEGETLFNDAAALVSFNLILQVYSTGSLTLIEGI
HHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QQLLFISVGGCLVGLVLGYLSIPVFNRLDDPLSSLLLTVAVALGTFQVGQFLGVSGAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VVAGLIFGNFGLSGNTSASSRITLLSFWEYASFTANTFIFLLIGVEINLVTLWQTLPAIL
HHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHH
LAVLAYQVGRVLTIYPLLAGVRWFDRPIPLRWQHLLFLGNIKGSLSMALALSLPTTLPGR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHEECCCCCCCH
ESLIAIVFGCVLVSLVGQGLSLPFLVKRLKLSKFSHSQQQVEELQAQLITAKAAQDELDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLKTGVLPKAVYEEMRSAYQVQVAGAEKALREFYNRRPDEFDHKSGAFSKLDAIRRRLLL
HHHHCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AEKGALTEAMRKRILSQDIGQNRIQTINEKLLQLDDD
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNITELIKISIILLLVATGVALLSRRLRVPYVTGLVLAGLPITELLSRPIGLDPALVLNL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCCHHHHHHH
FLPILIFEAGINTDISRLRSTFKPIALLAGPGAILSSAIIAILLKFGLGLNWIPAFLVGV
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ILANTDTVSMIAVFKEIPVPSRLSTIVEGETLFNDAAALVSFNLILQVYSTGSLTLIEGI
HHCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QQLLFISVGGCLVGLVLGYLSIPVFNRLDDPLSSLLLTVAVALGTFQVGQFLGVSGAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VVAGLIFGNFGLSGNTSASSRITLLSFWEYASFTANTFIFLLIGVEINLVTLWQTLPAIL
HHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHH
LAVLAYQVGRVLTIYPLLAGVRWFDRPIPLRWQHLLFLGNIKGSLSMALALSLPTTLPGR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHEECCCCCCCH
ESLIAIVFGCVLVSLVGQGLSLPFLVKRLKLSKFSHSQQQVEELQAQLITAKAAQDELDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLKTGVLPKAVYEEMRSAYQVQVAGAEKALREFYNRRPDEFDHKSGAFSKLDAIRRRLLL
HHHHCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AEKGALTEAMRKRILSQDIGQNRIQTINEKLLQLDDD
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]