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The map label for this gene is hisC

Identifier: 17229584

GI number: 17229584

Start: 2505711

End: 2506772

Strand: Direct

Name: hisC

Synonym: alr2092

Alternate gene names: 17229584

Gene position: 2505711-2506772 (Clockwise)

Preceding gene: 17229582

Following gene: 17229585

Centisome position: 39.07

GC content: 41.15

Gene sequence:

>1062_bases
ATGACTAATTACTTTCGGTCTAATGTTGAGGCTATGGCTAGTTATGTGCCTGGTGAACAGCCACCACAAGGGACACAGGT
GATTAAGCTCAACAGTAATGAGAACCCTTACCCTCCTTCACCTGAGGCATTAGCGGCAATAAAAGATATTGATGGTGAAT
GCTTACGACGATACCCAGAACCATTTGGGGAAGAATTTAGAAAGGCTGTAAGTCAACTTTTAGGTGTTCCTTGTAATTGG
GTGATTGTGGGTAATGGCAGTGACGAAATATTAAGCATAGTCATTCGTGCTTGTGCAGAACCGACGCGAAAGGTGGTTTA
TCCTGTGCCTACTTATGTGCTTTATCGCACATTAACCGAAATGCAGGCGGCGGACATTTTGGAGATTCCCTATAGGGAAT
ATAACATTTTACCTGTGGCAGACTTGATTGCTGCTCATGGCTCTGTGACATTTATTGCATCGCCTAATAGTCCATCTGGT
CATGTTGTACCAAGTGATGACTTACGGAAATTGGCTAGTGAATTATCTGGGGTTTTAGTTATAGATGAGGCTTATGTAGA
CTTTGCGGAAGAAAGTGCCTTGAATTTAGTTCAAGATCATGAAAATGTAATTTTGATTCGGACACTTTCTAAAGGATATT
CCTTAGCAGGATTGCGTTTAGGATTTGGGGTTGGAAATCCTCAACTATTGAATGGATTGTTTAAAGTAAAAGATAGCTAT
AATGTTGATGCGATCGCCTGCAAAGTAGCCACAGCAGCCATCACTGACCAAGCTTATAAAAACGCTTGCGTAGCCAAGGT
TAAAGCATCAAGAACTCGGTTAGCAAAAGACTTAAAGCAATTAGGTTTTTGTGTTTGGGATTCCCAAGCCAATTTTTTAC
TAACTCAACCTCCCCAGGGGAACGCCGAATACCTCTATCAACAACTTAGAGAAAAGAAGATTTTAATCCGCTACTTCAAA
CAACCAGGACTAGAAGATAAGTTACGTATTACTGTAGGCACTGATGAGCAAAACCAAATCTTGCTTCAGGCGTTGAGGGA
TTTGTTGGAAAGTAGAGATTAG

Upstream 100 bases:

>100_bases
ATTCTGTCTGCTTGAGATTCTTTCATATTGTACTGAATTCCATTTGTCTGACATTTTGCTAACCTAGATTGCATTTCTTG
ATTTGGAATTCTGAATTTTT

Downstream 100 bases:

>100_bases
GCTGTACTTTCAAACCCAGGTATTTATGGGGGAGATGTGGCTTCATTTCCTAAACTGCGCGTTCGCGTAGCGTTCCGTAG
GAAAAGGAACGCTAAAGCTA

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPEPFGEEFRKAVSQLLGVPCNW
VIVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTEMQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSG
HVVPSDDLRKLASELSGVLVIDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSY
NVDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQGNAEYLYQQLREKKILIRYFK
QPGLEDKLRITVGTDEQNQILLQALRDLLESRD

Sequences:

>Translated_353_residues
MTNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPEPFGEEFRKAVSQLLGVPCNW
VIVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTEMQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSG
HVVPSDDLRKLASELSGVLVIDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSY
NVDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQGNAEYLYQQLREKKILIRYFK
QPGLEDKLRITVGTDEQNQILLQALRDLLESRD
>Mature_352_residues
TNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPEPFGEEFRKAVSQLLGVPCNWV
IVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTEMQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSGH
VVPSDDLRKLASELSGVLVIDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSYN
VDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQGNAEYLYQQLREKKILIRYFKQ
PGLEDKLRITVGTDEQNQILLQALRDLLESRD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=358, Percent_Identity=30.4469273743017, Blast_Score=141, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322075, Length=363, Percent_Identity=29.4765840220386, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_NOSS1 (Q8YV89)

Other databases:

- EMBL:   BA000019
- PIR:   AF2067
- RefSeq:   NP_486132.1
- ProteinModelPortal:   Q8YV89
- STRING:   Q8YV89
- GeneID:   1105690
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr2092
- NMPDR:   fig|103690.1.peg.2399
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   SSHEIIN
- PhylomeDB:   Q8YV89
- ProtClustDB:   CLSK286108
- BioCyc:   NSP103690:ALR2092-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39106; Mature: 38975

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPE
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHCCC
PFGEEFRKAVSQLLGVPCNWVIVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTE
CCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
MQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSGHVVPSDDLRKLASELSGVLV
HHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEE
IDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSY
EEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
NVDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCCC
NAEYLYQQLREKKILIRYFKQPGLEDKLRITVGTDEQNQILLQALRDLLESRD
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPE
CCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHCCC
PFGEEFRKAVSQLLGVPCNWVIVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTE
CCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
MQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSGHVVPSDDLRKLASELSGVLV
HHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEE
IDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSY
EEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
NVDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCCC
NAEYLYQQLREKKILIRYFKQPGLEDKLRITVGTDEQNQILLQALRDLLESRD
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840