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The map label for this gene is nadC [H]

Identifier: 17229583

GI number: 17229583

Start: 2499350

End: 2500213

Strand: Reverse

Name: nadC [H]

Synonym: all2091

Alternate gene names: 17229583

Gene position: 2500213-2499350 (Counterclockwise)

Preceding gene: 17229586

Following gene: 17229581

Centisome position: 38.98

GC content: 44.33

Gene sequence:

>864_bases
GTGAGTAAAGCTGGTGTTTTGCCACCTTGGCTGGTTTTAGATCCATTATTACGTGGGTGGTTGTTGGAGGATATTGGTAG
GGGCGATCGCACTACGAATGGTCTGTTAGCCGCAGATGTTACTCTAGGATCAGCGAAGTGGATAGCGAAAACACCAGGGG
TAATTGCTGGCTTACCAGTTGCAGCAAGGGTATTTCAGCTTTTAAATGAAAAAGTTAGCTTTGTGACTACTGTTGATGAA
GGTGCTTTCTGTGAACCGGGACAGGTCGTGGCAGAAATTCATGGTTCGCTGGATGCTTTGTTGATGGGGGAACGGGTGGC
TCTTAACTTGGCTATGGGATTGAGTGGCATTGCAACGTTAACTAAAATATATGTAGAAAAAATTGCAGATTTACCTGCTT
GCTTAGTCGATACGCGCAAAACGACCCCAGGACTAAGACTTTTGGAAAAGTACGCGACTGCTATGGGTGGGGCGATTAAT
CACCGTATGGGGTTGGATGATGCGGTGATGATTAAGGATAATCATATTGCGGCTGCTGGGGGAATTGGTAAAGCTATTAC
GCGTATTCGTTCTCAGATTCCTTATACATTAACCATAGAAGTAGAAGCGGAAACTATTGAGCAGGTAAAAGAGGCTTTGG
AATACAAGGCTGACATTATTATGCTCGACAATATGCCCGTGGATTTGATGCGTCAGGCGGTACAGTTGATTCGTCAGCAG
GATAATGGTGTGAAAATTGAGGCTTCTGGGAACGTAACCTTAGAAACTATTCGCGCTGTGGCTGAGACTGGTGTTGATTA
TATTTCTAGTAGTGCGCCGATTACTCAGTCGAAATGGTTAGATTTGAGTATGAGAATTACATAA

Upstream 100 bases:

>100_bases
CAAAATTTTTTTGGATTTTATTTGCTGTCGCTACAAAGCTTATGGGATGAGGGTTTTAGGCTATAGTATTCCTGAAAGTT
GTTAGGGGAGTAATACAGTC

Downstream 100 bases:

>100_bases
ATAAAGATTGGGGTTTTAACTGTAGAAAAACACAGCTAAAAACCCAACCACCAAAATTATTTTACAAATTAGGCATTAAC
GATATAAGGCGAGTTAATTG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSKAGVLPPWLVLDPLLRGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPVAARVFQLLNEKVSFVTTVDE
GAFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATLTKIYVEKIADLPACLVDTRKTTPGLRLLEKYATAMGGAIN
HRMGLDDAVMIKDNHIAAAGGIGKAITRIRSQIPYTLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQ
DNGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMRIT

Sequences:

>Translated_287_residues
MSKAGVLPPWLVLDPLLRGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPVAARVFQLLNEKVSFVTTVDE
GAFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATLTKIYVEKIADLPACLVDTRKTTPGLRLLEKYATAMGGAIN
HRMGLDDAVMIKDNHIAAAGGIGKAITRIRSQIPYTLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQ
DNGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMRIT
>Mature_286_residues
SKAGVLPPWLVLDPLLRGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPVAARVFQLLNEKVSFVTTVDEG
AFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATLTKIYVEKIADLPACLVDTRKTTPGLRLLEKYATAMGGAINH
RMGLDDAVMIKDNHIAAAGGIGKAITRIRSQIPYTLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQD
NGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMRIT

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=288, Percent_Identity=36.8055555555556, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=41.1111111111111, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=34.5323741007194, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30872; Mature: 30741

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAGVLPPWLVLDPLLRGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHCCCCCCCCCCHH
AARVFQLLNEKVSFVTTVDEGAFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATL
HHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHCCHHHHHHCCHHEEHHHHHHHHHHHH
TKIYVEKIADLPACLVDTRKTTPGLRLLEKYATAMGGAINHRMGLDDAVMIKDNHIAAAG
HHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCEEECC
GIGKAITRIRSQIPYTLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQ
CHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHC
DNGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMRIT
CCCEEEEECCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SKAGVLPPWLVLDPLLRGWLLEDIGRGDRTTNGLLAADVTLGSAKWIAKTPGVIAGLPV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHCCCCCCCCCCHH
AARVFQLLNEKVSFVTTVDEGAFCEPGQVVAEIHGSLDALLMGERVALNLAMGLSGIATL
HHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHCCHHHHHHCCHHEEHHHHHHHHHHHH
TKIYVEKIADLPACLVDTRKTTPGLRLLEKYATAMGGAINHRMGLDDAVMIKDNHIAAAG
HHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCEEECC
GIGKAITRIRSQIPYTLTIEVEAETIEQVKEALEYKADIIMLDNMPVDLMRQAVQLIRQQ
CHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHC
DNGVKIEASGNVTLETIRAVAETGVDYISSSAPITQSKWLDLSMRIT
CCCEEEEECCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]