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The map label for this gene is ggt [H]

Identifier: 17229543

GI number: 17229543

Start: 2458069

End: 2459898

Strand: Direct

Name: ggt [H]

Synonym: alr2051

Alternate gene names: 17229543

Gene position: 2458069-2459898 (Clockwise)

Preceding gene: 17229541

Following gene: 17229546

Centisome position: 38.32

GC content: 45.79

Gene sequence:

>1830_bases
GTGTTTCTGTCCTCTTTCCCTGGAAAAAGTATAAAAATGCCTATGTTTACTAAGTCAAAGCGGGTTGTATGTACAGTTTT
TTCCCTTGGGGTTCTTTGTTACACCCAACTAGCCTCAGCCACTATTACCTTACCTCTGCGTAGTAAAAAAGGTATGGTAG
TATCTGCCCATCCTTTGGCAAGTGAGACTGGTGTGGCAATGTTACGCAAAGGTGGTAATGCAGTCGATGCAGCAGTAGCC
ACAACTTTGGCAATTTCCGTAGTTGAGCCATTTTCTGCCGGAATTGGTGGCGGGGGATTTTTGCTGATGCGTTCCCAGAA
AACAGGAGAAATCAAAGCGTTAGATTTTCGGGAACGCGCACCCCTCAAAGCCACGAGAAAGATGTATTTGGATGATGCAG
GTAAGGTGCGTCCAAATGCAAGTGTCAACGGTTATTTGGCGGTAGCTACACCAGGAACGATCGCCGGGATGTATGAAGTG
CATCGTCGTTATGGTAAATTACCCTGGCATGAGGTGGTAAAACCTGCGATCGCACTAGCGAAAGATGGTTTTGTTCTTGA
TCAAAAACCCACTTGGCGATCAATCCAAGTTTATGAAACCCGCAAACAAGCAATTCTCAGCAACCAAGCAGCACGGGAAA
TCTTCACTCGCAACGGTGAATTTTATCAGCCTGGGGAAAAGTTGGTGCAGCGTGATTTGGCAGGTACTTTGGAAGCGATC
GCCCAAAATCCCCAAAGCTTTTACACTGGTAATATTGCCCGTGCGATCGCGGCTGATATGGCGAAAAATGGCGGTTTAAT
TACCTTAGCAGACCTGAAAGCCTACAAACCCATCTGGCGTAATCCTGTCTGTGGCAATTTCCGTCAAGCTAAAATCTGCT
CAATGCCACCACCTTCATCAGGCGGTGTGTTGCTATTGCAGATGTTAAATATTATTGGTGACACAGATTTAAAATCCTGG
GGTTGGCATCATCCCGATGCGTTGCATTTATTCACAGAAGCAATGAAAATTACCTACAGCGATCGCTCACAATATTTAGG
CGACCCCGATTTTGTCAAAATTCCTCTACAAGCACTGATTAGTCCAGCCTACGGCAAAAAGCGTCGTGCAGAAATTGATT
TACACAGAGCCACACCCTCAACCCAAGTCAAACCCATTGCCCCAGAAATTTTACAACAATTGGAGAAAGCAGAGATTCCC
CAGAGAATATATGCAAATCGCTATGAATCTCCCGAAACCAGCCATATAAATGTCGTCGATGAAGAACGTAATGCAGTCAG
CCTCACTTTTACCGTTAATTATGGTTTTGGTTCTGGAGTGGTTGCATCGGGGACTGGTATTTTGCTCAACGATGAAATGG
ACGATTTTGCTGCTGCGCCAGGGGTTCCCAATGTATTTGGGTTAGTAGGCAGCGAAGCCAATGCGATTTCACCCCGCAAA
ACTCCCTTATCGAGTATGACACCAACTATCATCACCGAGAACGAACGCCTCCGTATGGTAGTAGGTGCGCCTGGTGGTAG
CACCATCATTACTCAAGTTTTGCAAATTATTCTCAATGTTTTAGAATACAATATGAATGTTGGTGCAGCCGTATCTGTCC
CACGCATACATCACCAGTGGCTACCCGATGAATTACGAGTAGAAACTTGGGGATTAGACGCGCTTACCCTACAAGACTTA
CGCCGACGCGGACATAACATCAAAGAAACTAATCCTTGGGGTAATATTAATGCGATCGTTGTCACCAAAGAAGGCGACTT
AGAAGGCGCAGCCGACCCACGCGGCGAAGGTTCTCCCAGAGGAGATATGAAACTAATAACTAATGACTAA

Upstream 100 bases:

>100_bases
TTTATTTTTTGGTGTTCCCTGATCTCAGATGATGTCATTTATGCCATTGCTAGATGTAGGCTAGTAAACAAGTACCTGAA
CCTAATCAATTATACCCATA

Downstream 100 bases:

>100_bases
TGACTACTGTCCATTAACCATAGACTCTGCATGAACACTGCTACCAAATTCGTTGGCACGGGCGCTGGGAACTAATGTCC
AGCCTGCTTTTAGTAACTTC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MFLSSFPGKSIKMPMFTKSKRVVCTVFSLGVLCYTQLASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVA
TTLAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASVNGYLAVATPGTIAGMYEV
HRRYGKLPWHEVVKPAIALAKDGFVLDQKPTWRSIQVYETRKQAILSNQAAREIFTRNGEFYQPGEKLVQRDLAGTLEAI
AQNPQSFYTGNIARAIAADMAKNGGLITLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSW
GWHHPDALHLFTEAMKITYSDRSQYLGDPDFVKIPLQALISPAYGKKRRAEIDLHRATPSTQVKPIAPEILQQLEKAEIP
QRIYANRYESPETSHINVVDEERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAISPRK
TPLSSMTPTIITENERLRMVVGAPGGSTIITQVLQIILNVLEYNMNVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDL
RRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPRGDMKLITND

Sequences:

>Translated_609_residues
MFLSSFPGKSIKMPMFTKSKRVVCTVFSLGVLCYTQLASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVA
TTLAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASVNGYLAVATPGTIAGMYEV
HRRYGKLPWHEVVKPAIALAKDGFVLDQKPTWRSIQVYETRKQAILSNQAAREIFTRNGEFYQPGEKLVQRDLAGTLEAI
AQNPQSFYTGNIARAIAADMAKNGGLITLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSW
GWHHPDALHLFTEAMKITYSDRSQYLGDPDFVKIPLQALISPAYGKKRRAEIDLHRATPSTQVKPIAPEILQQLEKAEIP
QRIYANRYESPETSHINVVDEERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAISPRK
TPLSSMTPTIITENERLRMVVGAPGGSTIITQVLQIILNVLEYNMNVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDL
RRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPRGDMKLITND
>Mature_609_residues
MFLSSFPGKSIKMPMFTKSKRVVCTVFSLGVLCYTQLASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVA
TTLAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASVNGYLAVATPGTIAGMYEV
HRRYGKLPWHEVVKPAIALAKDGFVLDQKPTWRSIQVYETRKQAILSNQAAREIFTRNGEFYQPGEKLVQRDLAGTLEAI
AQNPQSFYTGNIARAIAADMAKNGGLITLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSW
GWHHPDALHLFTEAMKITYSDRSQYLGDPDFVKIPLQALISPAYGKKRRAEIDLHRATPSTQVKPIAPEILQQLEKAEIP
QRIYANRYESPETSHINVVDEERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAISPRK
TPLSSMTPTIITENERLRMVVGAPGGSTIITQVLQIILNVLEYNMNVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDL
RRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPRGDMKLITND

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=32.7927927927928, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=32.7927927927928, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=32.7927927927928, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=32.7927927927928, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI113429326, Length=560, Percent_Identity=32.1428571428571, Blast_Score=233, Evalue=6e-61,
Organism=Homo sapiens, GI113429324, Length=553, Percent_Identity=31.6455696202532, Blast_Score=233, Evalue=6e-61,
Organism=Homo sapiens, GI109148539, Length=581, Percent_Identity=28.9156626506024, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI153266901, Length=501, Percent_Identity=28.5429141716567, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI153266885, Length=500, Percent_Identity=28.4, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266907, Length=500, Percent_Identity=27, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI30581157, Length=207, Percent_Identity=40.0966183574879, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI30581155, Length=207, Percent_Identity=40.0966183574879, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI218505805, Length=189, Percent_Identity=37.5661375661376, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310124095, Length=205, Percent_Identity=33.1707317073171, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789856, Length=553, Percent_Identity=46.8354430379747, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI212646519, Length=516, Percent_Identity=35.2713178294574, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI72000294, Length=516, Percent_Identity=35.2713178294574, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI193208247, Length=575, Percent_Identity=33.7391304347826, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI193208245, Length=575, Percent_Identity=33.7391304347826, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17506189, Length=581, Percent_Identity=32.7022375215146, Blast_Score=253, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17542894, Length=563, Percent_Identity=32.5044404973357, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI72001495, Length=239, Percent_Identity=30.1255230125523, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI72001497, Length=239, Percent_Identity=30.1255230125523, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17564448, Length=455, Percent_Identity=23.5164835164835, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323330, Length=530, Percent_Identity=30.188679245283, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24642670, Length=533, Percent_Identity=31.3320825515947, Blast_Score=235, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24642666, Length=533, Percent_Identity=31.3320825515947, Blast_Score=235, Evalue=9e-62,
Organism=Drosophila melanogaster, GI161077878, Length=533, Percent_Identity=31.3320825515947, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI161077880, Length=533, Percent_Identity=31.3320825515947, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45551474, Length=533, Percent_Identity=31.3320825515947, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI18859893, Length=556, Percent_Identity=34.8920863309352, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI161077496, Length=576, Percent_Identity=31.7708333333333, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI18859741, Length=548, Percent_Identity=27.7372262773723, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 66409; Mature: 66409

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLSSFPGKSIKMPMFTKSKRVVCTVFSLGVLCYTQLASATITLPLRSKKGMVVSAHPLA
CCCCCCCCCCEECCCCCCCCEEEEHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCC
SETGVAMLRKGGNAVDAAVATTLAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERA
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCC
PLKATRKMYLDDAGKVRPNASVNGYLAVATPGTIAGMYEVHRRYGKLPWHEVVKPAIALA
CHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KDGFVLDQKPTWRSIQVYETRKQAILSNQAAREIFTRNGEFYQPGEKLVQRDLAGTLEAI
CCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AQNPQSFYTGNIARAIAADMAKNGGLITLADLKAYKPIWRNPVCGNFRQAKICSMPPPSS
HCCCCHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCCCCCCEEECCCCCCC
GGVLLLQMLNIIGDTDLKSWGWHHPDALHLFTEAMKITYSDRSQYLGDPDFVKIPLQALI
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEECCHHHHCCCCCEEEEEHHHHC
SPAYGKKRRAEIDLHRATPSTQVKPIAPEILQQLEKAEIPQRIYANRYESPETSHINVVD
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEE
EERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAISPRK
CCCCEEEEEEEEEECCCCCEEECCCEEEECCCCHHHHCCCCCCHHHHCCCCCCCCCCCCC
TPLSSMTPTIITENERLRMVVGAPGGSTIITQVLQIILNVLEYNMNVGAAVSVPRIHHQW
CCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHC
LPDELRVETWGLDALTLQDLRRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPR
CCHHHEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
GDMKLITND
CCEEEEECC
>Mature Secondary Structure
MFLSSFPGKSIKMPMFTKSKRVVCTVFSLGVLCYTQLASATITLPLRSKKGMVVSAHPLA
CCCCCCCCCCEECCCCCCCCEEEEHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCC
SETGVAMLRKGGNAVDAAVATTLAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERA
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCC
PLKATRKMYLDDAGKVRPNASVNGYLAVATPGTIAGMYEVHRRYGKLPWHEVVKPAIALA
CHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KDGFVLDQKPTWRSIQVYETRKQAILSNQAAREIFTRNGEFYQPGEKLVQRDLAGTLEAI
CCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AQNPQSFYTGNIARAIAADMAKNGGLITLADLKAYKPIWRNPVCGNFRQAKICSMPPPSS
HCCCCHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCCCCCCEEECCCCCCC
GGVLLLQMLNIIGDTDLKSWGWHHPDALHLFTEAMKITYSDRSQYLGDPDFVKIPLQALI
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEECCHHHHCCCCCEEEEEHHHHC
SPAYGKKRRAEIDLHRATPSTQVKPIAPEILQQLEKAEIPQRIYANRYESPETSHINVVD
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEE
EERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAISPRK
CCCCEEEEEEEEEECCCCCEEECCCEEEECCCCHHHHCCCCCCHHHHCCCCCCCCCCCCC
TPLSSMTPTIITENERLRMVVGAPGGSTIITQVLQIILNVLEYNMNVGAAVSVPRIHHQW
CCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHC
LPDELRVETWGLDALTLQDLRRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPR
CCHHHEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
GDMKLITND
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]