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The map label for this gene is iolS [H]

Identifier: 17229546

GI number: 17229546

Start: 2461341

End: 2462300

Strand: Direct

Name: iolS [H]

Synonym: alr2054

Alternate gene names: 17229546

Gene position: 2461341-2462300 (Clockwise)

Preceding gene: 17229543

Following gene: 17229547

Centisome position: 38.38

GC content: 45.52

Gene sequence:

>960_bases
ATGGAAAAGCGAACATTAGGCACATCTGATGTCAAAATCTCACCCATTCTCATGGGAACTTGGCAAGCCGGGAAGAAAAT
GTGGGTGGGAATTGAAGATGCTGACTCGATTAAAACCATTCGGGCGGCTTTTGAGGCAGGAATTACCACCATTGACACAG
CCGAAGTTTATGGCGAAGGACATTCTGAACAGATTGTGGCTGAGGCTTTGTCTGATGTGCGTGGCCAAGTGGAATATGCA
ACAAAAGTTTTCGCCAACCATCTCAAGTATGATCAAGTGATTGAAGCTTGCGATCGCTCCCTGAAAAATCTCCAGACTGA
TTACATAGACTTGTATCAAATTCATTGGCCTGCTGGTGCTTTCAATAGTGCGATAGTACCAATTGAGGAAACCATGAACG
CCCTGAACTACCTGAAAGAGCAGGGAAAAATTCGCGCCATTGGTGTTTCTAACTTTTCCCGCACCCAATTAGCAGAAGCC
TCACAATATGGCAGAATTGACAGCTTACAGCCTCCCTATTCTCTATTTTGGCGACAAGTAGAAAAGGATGCAGCACCCTA
CTGTGTGGAAAATCATATTTCTATCTTGGCCTATTCGCCCTTAGCTCAGGGATTGTTGACAGGGAAATTTACTCGCGGAC
AGGAATTTGATCCAGCCGATAACCGAGCTAAAAATAAACTGTTTCAAGGCGAAAATTTTGAACGCGCCCAACAAGCTTTA
GATAAACTGCGCCCCATCGCCGAACGCCATAACGCTACTTTGGCGCAGTTAGCACTGGCTTGGTTAATTGCCCAACCCCA
AACGAATGCGATCGCCGGTGCGCGTTATCCTGAACAAGCGAAAGATAATGCCCAAGCTGCCAATATTCAACTCTCTACTG
ACGAAATTAGCGAAATTGATGCGATCGGTCGTATTGTTACCGACCATCATGATGATAGTCCTGTGATGTGGAATTGGTAA

Upstream 100 bases:

>100_bases
AATTCTATTAGCATCGGCATTTACTGTAACTCTGATTTAATTTGAAGCAAAGACCGTTAAAGTATGAAACTATCCAGGGA
AGTGAATTTAGAGAACTTTT

Downstream 100 bases:

>100_bases
AAGATTTCTTAAATATCACCCCAATTATCCACAAAAGATAGTTGGGGATCAAAGCTTTAAGATTTTATTGCAAAAATCTA
CAAAATATCAACTTTAGTAA

Product: aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTIDTAEVYGEGHSEQIVAEALSDVRGQVEYA
TKVFANHLKYDQVIEACDRSLKNLQTDYIDLYQIHWPAGAFNSAIVPIEETMNALNYLKEQGKIRAIGVSNFSRTQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQEFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAERHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSTDEISEIDAIGRIVTDHHDDSPVMWNW

Sequences:

>Translated_319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTIDTAEVYGEGHSEQIVAEALSDVRGQVEYA
TKVFANHLKYDQVIEACDRSLKNLQTDYIDLYQIHWPAGAFNSAIVPIEETMNALNYLKEQGKIRAIGVSNFSRTQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQEFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAERHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSTDEISEIDAIGRIVTDHHDDSPVMWNW
>Mature_319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTIDTAEVYGEGHSEQIVAEALSDVRGQVEYA
TKVFANHLKYDQVIEACDRSLKNLQTDYIDLYQIHWPAGAFNSAIVPIEETMNALNYLKEQGKIRAIGVSNFSRTQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQEFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAERHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSTDEISEIDAIGRIVTDHHDDSPVMWNW

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=331, Percent_Identity=29.607250755287, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI27436966, Length=331, Percent_Identity=29.607250755287, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI27436962, Length=331, Percent_Identity=29.607250755287, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI27436969, Length=329, Percent_Identity=29.7872340425532, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4504825, Length=326, Percent_Identity=29.7546012269939, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI41152114, Length=206, Percent_Identity=33.0097087378641, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI27436971, Length=329, Percent_Identity=27.0516717325228, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223718702, Length=208, Percent_Identity=34.1346153846154, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI41327764, Length=209, Percent_Identity=33.0143540669856, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI5453543, Length=333, Percent_Identity=26.7267267267267, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI45446745, Length=336, Percent_Identity=26.7857142857143, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503285, Length=336, Percent_Identity=26.7857142857143, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI223468663, Length=344, Percent_Identity=25, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310109922, Length=322, Percent_Identity=26.7080745341615, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI223718708, Length=151, Percent_Identity=35.7615894039735, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI310109920, Length=333, Percent_Identity=26.1261261261261, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788070, Length=314, Percent_Identity=38.2165605095541, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87081735, Length=321, Percent_Identity=34.5794392523364, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788081, Length=300, Percent_Identity=33.6666666666667, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1789199, Length=350, Percent_Identity=32.2857142857143, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1789375, Length=325, Percent_Identity=29.5384615384615, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786400, Length=284, Percent_Identity=28.8732394366197, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994888, Length=314, Percent_Identity=24.8407643312102, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082198, Length=294, Percent_Identity=26.1904761904762, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787674, Length=280, Percent_Identity=25.3571428571429, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17537077, Length=320, Percent_Identity=27.8125, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17537075, Length=320, Percent_Identity=27.8125, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17566692, Length=333, Percent_Identity=25.5255255255255, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=243, Percent_Identity=27.5720164609054, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645785, Length=311, Percent_Identity=28.6173633440514, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552492, Length=212, Percent_Identity=29.2452830188679, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=26.1290322580645, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998625, Length=307, Percent_Identity=24.7557003257329, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538386, Length=310, Percent_Identity=24.5161290322581, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537079, Length=327, Percent_Identity=24.1590214067278, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=333, Percent_Identity=28.8288288288288, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323998, Length=331, Percent_Identity=25.9818731117825, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319958, Length=299, Percent_Identity=24.7491638795987, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324694, Length=218, Percent_Identity=28.8990825688073, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319951, Length=331, Percent_Identity=23.8670694864048, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320079, Length=275, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644950, Length=319, Percent_Identity=27.8996865203762, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646155, Length=180, Percent_Identity=36.6666666666667, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221378297, Length=336, Percent_Identity=26.1904761904762, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646159, Length=174, Percent_Identity=32.7586206896552, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=23.1034482758621, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640980, Length=340, Percent_Identity=23.8235294117647, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24662789, Length=337, Percent_Identity=24.9258160237389, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549126, Length=340, Percent_Identity=23.8235294117647, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45553081, Length=180, Percent_Identity=30, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35610; Mature: 35610

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTIDTAEVYGEG
CCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHCCC
HSEQIVAEALSDVRGQVEYATKVFANHLKYDQVIEACDRSLKNLQTDYIDLYQIHWPAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FNSAIVPIEETMNALNYLKEQGKIRAIGVSNFSRTQLAEASQYGRIDSLQPPYSLFWRQV
CCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
EKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQEFDPADNRAKNKLFQGENFERAQQAL
HHCCCCEEHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
DKLRPIAERHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSTDEISEID
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCEEEEECHHHHHHHH
AIGRIVTDHHDDSPVMWNW
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTIDTAEVYGEG
CCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHCCC
HSEQIVAEALSDVRGQVEYATKVFANHLKYDQVIEACDRSLKNLQTDYIDLYQIHWPAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FNSAIVPIEETMNALNYLKEQGKIRAIGVSNFSRTQLAEASQYGRIDSLQPPYSLFWRQV
CCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
EKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQEFDPADNRAKNKLFQGENFERAQQAL
HHCCCCEEHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
DKLRPIAERHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSTDEISEID
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCEEEEECHHHHHHHH
AIGRIVTDHHDDSPVMWNW
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]