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The map label for this gene is clpB [H]

Identifier: 17229455

GI number: 17229455

Start: 2344408

End: 2346852

Strand: Direct

Name: clpB [H]

Synonym: alr1963

Alternate gene names: 17229455

Gene position: 2344408-2346852 (Clockwise)

Preceding gene: 17229453

Following gene: 17229457

Centisome position: 36.55

GC content: 48.3

Gene sequence:

>2445_bases
ATGTTTGAACACTTCACTTCCGAAGCCATCAAAGTCATTATGCTCGCTCAGGAGGAAGCACGTCGCCTGGGACACAATTT
CGTAGGAACTGAGCAAATTCTCCTGGGTTTGATGGGAGAAGGAACTGGGGTTGCTGCCAAAGTGCTGACTGAGATGGGTG
TGACTCTTAAAGACGCTCGTCGTGAGGTTGAAAAAATCATTGGTAGGGGTTCTGGGTTCGTACCGCCAGAAATTCCTTTT
ACCCCGAAAGTGAAAAGCCTCTTCGAGCAGTCCTTTAGAGAAGCGCATAATCTCGGAAATAACTACATCAACACAGAACA
TTTACTCTTAGGGTTAACAGAAGCCGGTGAAGGTGTCGCCGCTAAGGTTTTACAGAATCTTGGTGTTGACCTCAAGAGTG
TCCGCTCTGCTGTCATCCGTCGCTTAGGCGAAGACCCAACCGTGGTTGTGGGTGGTGGCGGTTCCAGACGGAACCAAACA
CCGATGATGGAAGAGTTTGGCAGAAATCTGACGAAATTAGCCAAAGAAGGTAAACTCGACCCTGTAGTAGGTCGGCAAAA
AGAAATTGAGCGTACTGTGCAGATTCTCGGCCGTCGTACCAAGAATAACCCCGTGTTAATTGGTGAACCAGGGGTTGGTA
AAACTGCAATCGCTGAAGGTTTAGCACAGCGTATTATTAACCAAGATGTCCCCGACATTTTGCAAGATAAACAAGTCGTC
AGCCTGGATATGGGTTCTCTGGTAGCGGGAACTCGCTTCCGGGGAGACTTTGAAGAGCGCATCAAGAAAATCGTAGAAGA
AGTCCGTTCTGCGGGTAATATCATCCTGGTGATAGATGAAATTCATACCTTAGTTGGTGCAGGGGGAACAGAAGGCGGCT
TAGATGCAGCCAATATCCTCAAACCAGCCTTGGCCAGGGGTGAATTGCAATGTATTGGCGCTACCACATTAGATGAATAT
CGTCAATACATCGAACGCGATGCGGCCTTAGAGCGACGTTTCCAACCGATTATGGTCGGGGAACCATCCGTAGCCGAAAC
CATTGATATCCTCTATGGTTTGCGCGGAGCCTACGAACAGCACCACAAAGTACATATTTCCGATGAGGCTGTGGTAGCAG
CAGCGCAATTGGCTGATAGATATATTAGCGATCGCTTCCTGCCCGATAAAGCCATAGACTTAATTGATGAAGCTGGCTCT
CGTGTGCGCCTGCGGAACTCGCAAATTTCCCCTAACAAGGAACTCAAGCGCCAACTGACTGACATCACCAAAAGCAAAAA
CGAAGCAGTTAGACTCCAAGACTTCGATAAAGCCGCAAAACTCCGTGACGAAGAAATTGCCCTAGAAACAGAACTGCAAG
CAGCCACCACTGGCCAAACCATCAAGCCAGTTGTGGATGAAGAAGACATTGCCCAAATTGTCGCCTCTTGGACTGGTGTC
CCAGTTAACAAGCTGACAGAATCTGAGTCTGAGTTGCTTCTGCACCTAGAAGATACTCTCCACAAACGGTTAATTGGTCA
AGAGCAAGCAGTTACATCGGTTTCTCGCGCCATCCGTCGCGCCAGAGTCGGGTTAAAGAGTCCCAACCGTCCCATTGCTA
GCTTTATTTTCTCCGGGCCTACCGGAGTCGGGAAAACCGAACTAGCCAAAGCATTAGCAGCTTACTTCTTTGGCGCGGAA
GATGCCATGATTCGGTTTGATATGTCCGAATACATGGAAAGCCACACCGTTTCTAAACTCATCGGCTCTCCTCCTGGTTA
CGTCGGCTACGACGAAGGCGGACAACTCACTGAAGCCGTGCGGCGTAGACCATACACAGTGTTGCTGTTCGACGAAATCG
AAAAAGCGCACCCCGATGTATTCAATATGCTGCTGCAACTTTTAGATGACGGACACCTCACCGATGCCAAAGGTCGGAAA
GTGGACTTCAAGAACACCTTGATTATCCTGACTTCTAACATTGGTTCTAAGGTAATTGAAAAAGGTGGCGGCGGTTTAGG
CTTTGAATTTGACAACCAAGCCGAAGCTAGTTACAACCGCATCCGCAACTTAGTCAACGAAGAACTGAAAAATTACTTCC
GTCCTGAGTTCCTCAACCGACTTGATGAAGTCATCGTCTTCACTCAACTGTCGAGAGATGAAGTCAAGCAAATCGCTGAT
ATCATGCTGCGTGATGTCGCCAGCCGCCTGACCGAGAAGGGAATTACCTTAGAAGTTACCGAACGGTTCAAAGAATTAGT
AGTAACAGAAGGTTATAACCCCAGCTACGGTGCTAGACCATTACGCCGTGCAATCATGCGCCTCCTAGAAGATTCCTTAG
CGGAAGTGTTGCTGTCTGGAGAAATCACCGAGGGAGACACAGCCATTGCTGATGTCAACGATGACGGTCAAGTACAAATA
CGCCAGTCAGAAGAAAGAGAGTTACTTCTAGCCAATGTAGGCTAA

Upstream 100 bases:

>100_bases
ATAAAGATACATTGTCTTTAAGAAAGTACAAAAAAGTTTAACAAAAGGGTGAATTTTTAAGTCACCCAAAGTCCAAGCAG
CAAGGGAGCAAGAACCCGCT

Downstream 100 bases:

>100_bases
TTCTCAGATATTCCAAGCTTGACAACACATAATTTCCTTATCAATAAAATTTAGGTTAGACCCTAGTATAAAAACTAGGG
TCTTTTTTTATTCAACTAAA

Product: endopeptidase Clp ATP-binding chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MFEHFTSEAIKVIMLAQEEARRLGHNFVGTEQILLGLMGEGTGVAAKVLTEMGVTLKDARREVEKIIGRGSGFVPPEIPF
TPKVKSLFEQSFREAHNLGNNYINTEHLLLGLTEAGEGVAAKVLQNLGVDLKSVRSAVIRRLGEDPTVVVGGGGSRRNQT
PMMEEFGRNLTKLAKEGKLDPVVGRQKEIERTVQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIINQDVPDILQDKQVV
SLDMGSLVAGTRFRGDFEERIKKIVEEVRSAGNIILVIDEIHTLVGAGGTEGGLDAANILKPALARGELQCIGATTLDEY
RQYIERDAALERRFQPIMVGEPSVAETIDILYGLRGAYEQHHKVHISDEAVVAAAQLADRYISDRFLPDKAIDLIDEAGS
RVRLRNSQISPNKELKRQLTDITKSKNEAVRLQDFDKAAKLRDEEIALETELQAATTGQTIKPVVDEEDIAQIVASWTGV
PVNKLTESESELLLHLEDTLHKRLIGQEQAVTSVSRAIRRARVGLKSPNRPIASFIFSGPTGVGKTELAKALAAYFFGAE
DAMIRFDMSEYMESHTVSKLIGSPPGYVGYDEGGQLTEAVRRRPYTVLLFDEIEKAHPDVFNMLLQLLDDGHLTDAKGRK
VDFKNTLIILTSNIGSKVIEKGGGGLGFEFDNQAEASYNRIRNLVNEELKNYFRPEFLNRLDEVIVFTQLSRDEVKQIAD
IMLRDVASRLTEKGITLEVTERFKELVVTEGYNPSYGARPLRRAIMRLLEDSLAEVLLSGEITEGDTAIADVNDDGQVQI
RQSEERELLLANVG

Sequences:

>Translated_814_residues
MFEHFTSEAIKVIMLAQEEARRLGHNFVGTEQILLGLMGEGTGVAAKVLTEMGVTLKDARREVEKIIGRGSGFVPPEIPF
TPKVKSLFEQSFREAHNLGNNYINTEHLLLGLTEAGEGVAAKVLQNLGVDLKSVRSAVIRRLGEDPTVVVGGGGSRRNQT
PMMEEFGRNLTKLAKEGKLDPVVGRQKEIERTVQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIINQDVPDILQDKQVV
SLDMGSLVAGTRFRGDFEERIKKIVEEVRSAGNIILVIDEIHTLVGAGGTEGGLDAANILKPALARGELQCIGATTLDEY
RQYIERDAALERRFQPIMVGEPSVAETIDILYGLRGAYEQHHKVHISDEAVVAAAQLADRYISDRFLPDKAIDLIDEAGS
RVRLRNSQISPNKELKRQLTDITKSKNEAVRLQDFDKAAKLRDEEIALETELQAATTGQTIKPVVDEEDIAQIVASWTGV
PVNKLTESESELLLHLEDTLHKRLIGQEQAVTSVSRAIRRARVGLKSPNRPIASFIFSGPTGVGKTELAKALAAYFFGAE
DAMIRFDMSEYMESHTVSKLIGSPPGYVGYDEGGQLTEAVRRRPYTVLLFDEIEKAHPDVFNMLLQLLDDGHLTDAKGRK
VDFKNTLIILTSNIGSKVIEKGGGGLGFEFDNQAEASYNRIRNLVNEELKNYFRPEFLNRLDEVIVFTQLSRDEVKQIAD
IMLRDVASRLTEKGITLEVTERFKELVVTEGYNPSYGARPLRRAIMRLLEDSLAEVLLSGEITEGDTAIADVNDDGQVQI
RQSEERELLLANVG
>Mature_814_residues
MFEHFTSEAIKVIMLAQEEARRLGHNFVGTEQILLGLMGEGTGVAAKVLTEMGVTLKDARREVEKIIGRGSGFVPPEIPF
TPKVKSLFEQSFREAHNLGNNYINTEHLLLGLTEAGEGVAAKVLQNLGVDLKSVRSAVIRRLGEDPTVVVGGGGSRRNQT
PMMEEFGRNLTKLAKEGKLDPVVGRQKEIERTVQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIINQDVPDILQDKQVV
SLDMGSLVAGTRFRGDFEERIKKIVEEVRSAGNIILVIDEIHTLVGAGGTEGGLDAANILKPALARGELQCIGATTLDEY
RQYIERDAALERRFQPIMVGEPSVAETIDILYGLRGAYEQHHKVHISDEAVVAAAQLADRYISDRFLPDKAIDLIDEAGS
RVRLRNSQISPNKELKRQLTDITKSKNEAVRLQDFDKAAKLRDEEIALETELQAATTGQTIKPVVDEEDIAQIVASWTGV
PVNKLTESESELLLHLEDTLHKRLIGQEQAVTSVSRAIRRARVGLKSPNRPIASFIFSGPTGVGKTELAKALAAYFFGAE
DAMIRFDMSEYMESHTVSKLIGSPPGYVGYDEGGQLTEAVRRRPYTVLLFDEIEKAHPDVFNMLLQLLDDGHLTDAKGRK
VDFKNTLIILTSNIGSKVIEKGGGGLGFEFDNQAEASYNRIRNLVNEELKNYFRPEFLNRLDEVIVFTQLSRDEVKQIAD
IMLRDVASRLTEKGITLEVTERFKELVVTEGYNPSYGARPLRRAIMRLLEDSLAEVLLSGEITEGDTAIADVNDDGQVQI
RQSEERELLLANVG

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=315, Percent_Identity=38.7301587301587, Blast_Score=205, Evalue=1e-52,
Organism=Escherichia coli, GI1788943, Length=865, Percent_Identity=43.3526011560694, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=787, Percent_Identity=39.7712833545108, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=45.8923512747875, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6323002, Length=335, Percent_Identity=43.2835820895522, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 89928; Mature: 89928

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHFTSEAIKVIMLAQEEARRLGHNFVGTEQILLGLMGEGTGVAAKVLTEMGVTLKDAR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHH
REVEKIIGRGSGFVPPEIPFTPKVKSLFEQSFREAHNLGNNYINTEHLLLGLTEAGEGVA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHH
AKVLQNLGVDLKSVRSAVIRRLGEDPTVVVGGGGSRRNQTPMMEEFGRNLTKLAKEGKLD
HHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHCHHHHHHHHCCCCC
PVVGRQKEIERTVQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIINQDVPDILQDKQVV
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEE
SLDMGSLVAGTRFRGDFEERIKKIVEEVRSAGNIILVIDEIHTLVGAGGTEGGLDAANIL
EECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHH
KPALARGELQCIGATTLDEYRQYIERDAALERRFQPIMVGEPSVAETIDILYGLRGAYEQ
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHH
HHKVHISDEAVVAAAQLADRYISDRFLPDKAIDLIDEAGSRVRLRNSQISPNKELKRQLT
CCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHH
DITKSKNEAVRLQDFDKAAKLRDEEIALETELQAATTGQTIKPVVDEEDIAQIVASWTGV
HHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
PVNKLTESESELLLHLEDTLHKRLIGQEQAVTSVSRAIRRARVGLKSPNRPIASFIFSGP
CHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
TGVGKTELAKALAAYFFGAEDAMIRFDMSEYMESHTVSKLIGSPPGYVGYDEGGQLTEAV
CCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RRRPYTVLLFDEIEKAHPDVFNMLLQLLDDGHLTDAKGRKVDFKNTLIILTSNIGSKVIE
HHCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCHHHHH
KGGGGLGFEFDNQAEASYNRIRNLVNEELKNYFRPEFLNRLDEVIVFTQLSRDEVKQIAD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
IMLRDVASRLTEKGITLEVTERFKELVVTEGYNPSYGARPLRRAIMRLLEDSLAEVLLSG
HHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
EITEGDTAIADVNDDGQVQIRQSEERELLLANVG
CCCCCCCEEEECCCCCCEEEECCCCCEEEEECCC
>Mature Secondary Structure
MFEHFTSEAIKVIMLAQEEARRLGHNFVGTEQILLGLMGEGTGVAAKVLTEMGVTLKDAR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHH
REVEKIIGRGSGFVPPEIPFTPKVKSLFEQSFREAHNLGNNYINTEHLLLGLTEAGEGVA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHH
AKVLQNLGVDLKSVRSAVIRRLGEDPTVVVGGGGSRRNQTPMMEEFGRNLTKLAKEGKLD
HHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHCHHHHHHHHCCCCC
PVVGRQKEIERTVQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIINQDVPDILQDKQVV
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEE
SLDMGSLVAGTRFRGDFEERIKKIVEEVRSAGNIILVIDEIHTLVGAGGTEGGLDAANIL
EECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHH
KPALARGELQCIGATTLDEYRQYIERDAALERRFQPIMVGEPSVAETIDILYGLRGAYEQ
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHH
HHKVHISDEAVVAAAQLADRYISDRFLPDKAIDLIDEAGSRVRLRNSQISPNKELKRQLT
CCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHH
DITKSKNEAVRLQDFDKAAKLRDEEIALETELQAATTGQTIKPVVDEEDIAQIVASWTGV
HHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
PVNKLTESESELLLHLEDTLHKRLIGQEQAVTSVSRAIRRARVGLKSPNRPIASFIFSGP
CHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
TGVGKTELAKALAAYFFGAEDAMIRFDMSEYMESHTVSKLIGSPPGYVGYDEGGQLTEAV
CCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RRRPYTVLLFDEIEKAHPDVFNMLLQLLDDGHLTDAKGRKVDFKNTLIILTSNIGSKVIE
HHCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCHHHHH
KGGGGLGFEFDNQAEASYNRIRNLVNEELKNYFRPEFLNRLDEVIVFTQLSRDEVKQIAD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
IMLRDVASRLTEKGITLEVTERFKELVVTEGYNPSYGARPLRRAIMRLLEDSLAEVLLSG
HHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
EITEGDTAIADVNDDGQVQIRQSEERELLLANVG
CCCCCCCEEEECCCCCCEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]