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The map label for this gene is hisG [H]

Identifier: 17229457

GI number: 17229457

Start: 2347731

End: 2348375

Strand: Direct

Name: hisG [H]

Synonym: alr1965

Alternate gene names: 17229457

Gene position: 2347731-2348375 (Clockwise)

Preceding gene: 17229455

Following gene: 17229458

Centisome position: 36.6

GC content: 42.17

Gene sequence:

>645_bases
ATGTTAACTGTTGCGTTGCCGAAAGGGGAACTACTCAAAAATAGCATCCGCCTACTGCAATCTGTAGGGTTGGATTTTAG
TGCTTTTTTAGACTCAGGGAATCGTCAGTTGCAAATCACTGATGCTAGTGGAACGGCGAAAGGGTTGTTAGTTAGAGGTC
AAGATGTGCCTGTTTATGTGGAGTATGGACAAGCTCAAATTGGTATTATTGGTTACGATGTCCTCCGTGAGAAACAACCA
CAAGTTGCTCATTTAGTTGATTTACAGTTTGGCTATTGTCGGATGTCGGTGGCGGTAAAAGCATCTAGTCCCTACAAATC
ACCGCTAGATTTACCTGCTCACAGTCGTGTTGCTTCTAAATATGTCAATTCGGCGCGCGAGTTCTTCCAAGGTTTAGATT
TACCTGTGGAAATTGTCCCGCTTTACGGTTCCGTGGAATTAGGGCCAATCACAGGAATGTCTGAGGCAATTGTCGATATA
GTTTCTACAGGCCGGACTTTAAAAGAAAATGGTTTGGTGGAAATTACAACTTTATATGAAAGTACGGCACGGTTAATTGC
TCATCCCCTTAGTTATCGCTTGAATACAGGGAATTTACATCAATTAGTTGAGCAATTACGAGAGGGTGCTTTGACTAAAG
TTTAA

Upstream 100 bases:

>100_bases
ATGCTGCTTGAGGTAAGCATTAGAGATATTCTCAATATTAATGAACTGCTAAGACAAGGACACGATAAAGTGTCTCTAGC
CAAGGATACCAAGAAAACGA

Downstream 100 bases:

>100_bases
ATTAGTTTTGTCAGGTGTTAGTAGTCAGTTGTCACTGATAGAAGGTGCAACTGATTATATACTTTCAACAAAAACTTCTT
TACGAAAGCATCTTCTTGTA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGNRQLQITDASGTAKGLLVRGQDVPVYVEYGQAQIGIIGYDVLREKQP
QVAHLVDLQFGYCRMSVAVKASSPYKSPLDLPAHSRVASKYVNSAREFFQGLDLPVEIVPLYGSVELGPITGMSEAIVDI
VSTGRTLKENGLVEITTLYESTARLIAHPLSYRLNTGNLHQLVEQLREGALTKV

Sequences:

>Translated_214_residues
MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGNRQLQITDASGTAKGLLVRGQDVPVYVEYGQAQIGIIGYDVLREKQP
QVAHLVDLQFGYCRMSVAVKASSPYKSPLDLPAHSRVASKYVNSAREFFQGLDLPVEIVPLYGSVELGPITGMSEAIVDI
VSTGRTLKENGLVEITTLYESTARLIAHPLSYRLNTGNLHQLVEQLREGALTKV
>Mature_214_residues
MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGNRQLQITDASGTAKGLLVRGQDVPVYVEYGQAQIGIIGYDVLREKQP
QVAHLVDLQFGYCRMSVAVKASSPYKSPLDLPAHSRVASKYVNSAREFFQGLDLPVEIVPLYGSVELGPITGMSEAIVDI
VSTGRTLKENGLVEITTLYESTARLIAHPLSYRLNTGNLHQLVEQLREGALTKV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=175, Percent_Identity=33.7142857142857, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=193, Percent_Identity=32.1243523316062, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23325; Mature: 23325

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGNRQLQITDASGTAKGLLVRGQDVPVYV
CEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEEE
EYGQAQIGIIGYDVLREKQPQVAHLVDLQFGYCRMSVAVKASSPYKSPLDLPAHSRVASK
EECCEEEEEEEHHHHHCCCCCCEEHEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHH
YVNSAREFFQGLDLPVEIVPLYGSVELGPITGMSEAIVDIVSTGRTLKENGLVEITTLYE
HHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCCEEEEEHHH
STARLIAHPLSYRLNTGNLHQLVEQLREGALTKV
HHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGNRQLQITDASGTAKGLLVRGQDVPVYV
CEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEEE
EYGQAQIGIIGYDVLREKQPQVAHLVDLQFGYCRMSVAVKASSPYKSPLDLPAHSRVASK
EECCEEEEEEEHHHHHCCCCCCEEHEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHH
YVNSAREFFQGLDLPVEIVPLYGSVELGPITGMSEAIVDIVSTGRTLKENGLVEITTLYE
HHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCCEEEEEHHH
STARLIAHPLSYRLNTGNLHQLVEQLREGALTKV
HHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA