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The map label for this gene is trxA [H]

Identifier: 17229358

GI number: 17229358

Start: 2228946

End: 2229278

Strand: Reverse

Name: trxA [H]

Synonym: all1866

Alternate gene names: 17229358

Gene position: 2229278-2228946 (Counterclockwise)

Preceding gene: 17229363

Following gene: 17229357

Centisome position: 34.76

GC content: 43.54

Gene sequence:

>333_bases
ATGTCATCCATTACAAATGTTACAGAAGCCACATTCAAGCAAGAAGTTCTGGATAGCAACGTTCCAGTTCTAGTGGACTT
TTGGGCCCCTTGGTGTGGCCCTTGTCGGATGGTAGCGCCGGTTGTGGATGAAGTTGCTAGCGAATACGAAGGACTAGTGA
AAGTGGTAAAACTGAATACAGATCAAAATCCCACTGTTGCCAGTCATTACGGAATTCGTAGCATTCCTACACTAATGGTT
TTTAAGGGTGGAAGGCAAGTTAATACAGTTGTAGGGGCTGTTTCCAAGACCACATTGACTAAGACTTTAACACAGCATAT
TCAAGAAGCGTAA

Upstream 100 bases:

>100_bases
TCTGGATGATACAGAAATCTCATAGTTGCATTATCTCTGAAAATAAATTATATTTTTATTATTCGATAATATCGAATAAA
CGAATTAAGGGGCAAGTAAT

Downstream 100 bases:

>100_bases
CCCGCATTTCTCACAAGCTTTAGGTGTCTGATGAAGCAGAGAGGCAAAGGGGAAATAACCTGTATAAGAACTCTCCTCTG
CTCCCTGTTTCTATCTCTCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSSITNVTEATFKQEVLDSNVPVLVDFWAPWCGPCRMVAPVVDEVASEYEGLVKVVKLNTDQNPTVASHYGIRSIPTLMV
FKGGRQVNTVVGAVSKTTLTKTLTQHIQEA

Sequences:

>Translated_110_residues
MSSITNVTEATFKQEVLDSNVPVLVDFWAPWCGPCRMVAPVVDEVASEYEGLVKVVKLNTDQNPTVASHYGIRSIPTLMV
FKGGRQVNTVVGAVSKTTLTKTLTQHIQEA
>Mature_109_residues
SSITNVTEATFKQEVLDSNVPVLVDFWAPWCGPCRMVAPVVDEVASEYEGLVKVVKLNTDQNPTVASHYGIRSIPTLMVF
KGGRQVNTVVGAVSKTTLTKTLTQHIQEA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=32.2916666666667, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=36.4705882352941, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=93, Percent_Identity=30.1075268817204, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=50, Blast_Score=124, Evalue=1e-30,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=43.3962264150943, Blast_Score=104, Evalue=2e-24,
Organism=Escherichia coli, GI87081747, Length=93, Percent_Identity=31.1827956989247, Blast_Score=66, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=88, Percent_Identity=37.5, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=34.8314606741573, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=43.0555555555556, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=85, Percent_Identity=40, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=85, Percent_Identity=40, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=78, Percent_Identity=39.7435897435897, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=39.4366197183099, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=86, Percent_Identity=32.5581395348837, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=85, Percent_Identity=30.5882352941176, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=30.5882352941176, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=82, Percent_Identity=37.8048780487805, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=36.1111111111111, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=37.1794871794872, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=45.0704225352113, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=42.2535211267606, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=31.5217391304348, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=81, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=38, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=38.2978723404255, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=38.3720930232558, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921434, Length=86, Percent_Identity=32.5581395348837, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647799, Length=102, Percent_Identity=36.2745098039216, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=34.5679012345679, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11991; Mature: 11860

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSITNVTEATFKQEVLDSNVPVLVDFWAPWCGPCRMVAPVVDEVASEYEGLVKVVKLNT
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
DQNPTVASHYGIRSIPTLMVFKGGRQVNTVVGAVSKTTLTKTLTQHIQEA
CCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSITNVTEATFKQEVLDSNVPVLVDFWAPWCGPCRMVAPVVDEVASEYEGLVKVVKLNT
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
DQNPTVASHYGIRSIPTLMVFKGGRQVNTVVGAVSKTTLTKTLTQHIQEA
CCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]