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The map label for this gene is dac [H]

Identifier: 17229158

GI number: 17229158

Start: 1987791

End: 1989254

Strand: Direct

Name: dac [H]

Synonym: alr1666

Alternate gene names: 17229158

Gene position: 1987791-1989254 (Clockwise)

Preceding gene: 17229157

Following gene: 17229159

Centisome position: 30.99

GC content: 39.14

Gene sequence:

>1464_bases
ATGCCCCGAAAAATTTCTCTTGGCTTGATGGCATTATTTATTAGTGTTCAAGTTAGTGTTACCCAGCAACTAGTTAAAGC
CCAAACCCCAACCGCACCTACACCAACCACAAAATCTATTTGTCCGGCAGAATTGGGAACAGCCATAGATACAATAGTCA
ATCGTCCTTTATTCAATCGAGTGCGCTGGGGTATTTTAGTCAAACCTCTGTCATCTATGCAAACTCTTTACAGCCGAGAT
GCAGAGAAATACTTCACTCCTGCTTCTAATGCTAAATTGCTGACTACAGCTGCTGCCTTACAACAACTAGGTGCAGACTT
TCGTATTCGTACTTCAATTTATCAAAATGGTAATGGCAATTTCACTATTGTTGGTAGAGGTGATCCTAGCCTCAGCGATA
CTCAATTGCAATCACTAGCACAACAACTAAAACAAAAAGGTATCACCCAAGTTAATCAGCTAATTGCTGATGATAGTTAT
ATTCAAGGGGATATTGTTAACTCGACTTGGCAATGGGAAGATGTGCAGTCAAATTATGGTGCGCCAGTCAATAGTTTTAT
TTTGAATCAAAATGTATTTGGTTTAAAACTTATTCCTCAAATTGTAGGTAAGACTCCACAATTGTTGTGGAATGACCCCA
ATGAAGCAAGACAATGGTTGATCATCAATCAATCTGTGACAGTTGCAGCAAACCAACCAAGTTATATTGATGTTAGCCGT
GATTTAACAGGAAAAGTGCTGCGAATTAAAGGACAAATTGCAGCTAATTCCACTCCATATTTAGTAGAATTGCCTGTAGT
TGATCCTAATTATTACTTCCTGCGGCGTTTTCGTAGTGCCTTATCCACAGAAAAAATTAGTTTGGGTACAACATTAGTTG
CTTCTAGTGCTTCTAATCAACAGGAATTAGCTGCTGTACAGTCTCCGCCTTTATCACAATTATTGATAGAGACAAATCAA
AATAGTAATAATCTGTATGCCGAGGCATTGTTAAGAGCATTGGCTTTCAAACAACCTAGAGTGCAAAATAAAAGTACTGC
TAATATTGGCTTAGATGTTATTAAAGTGACCTTAAATAAATTAGGAGTTGACCCGACAGGTTATGTTTTGATAGATGCTT
CTGGTTTATCACGCCGTAATTTAGTCACCCCTGAAGCTTTAGTACAAACCTTGCAAGGAATAGCCAAAACACCAGCCGCC
AATGTATATCGTGCTTCCTTACCTATAGCCGGAAAAAGTGGTACTTTGAGCAACCGCCTTCGTAATACTCCAGCTCAAGG
CATCGTACAAGCTAAAACTGGTACATTAAGCGGTGCAATTTCTTTATCTGGATACGTCAATAGCTCTCAATATGAACCTT
TAGCGTTTAGTATTATGGTGAATCAATCGGAGCAGCCTGCAAGTGCTTTGCGCCAAGCAATTGATGAGATAGTTGTGTTA
TTGGCACAGCTAAAGCGTTGTTAA

Upstream 100 bases:

>100_bases
CACAGTTTAACAGCCTCTCATTAGAGAATAATGCTTTCCCGCACCTGTTGCTTCAATTCATAAGCAAGTTATCATCATCA
AGTAGTTTTAAACACTCTGT

Downstream 100 bases:

>100_bases
TTTGCTCTTTTTTGAATTTGAGCGTAGTTTGCTAGGGTGCGTCAGTATAAGTAATTTCCGAGTATAGTTTAGATTTCATC
GCACTGGCGCACCTCTAATT

Product: hypothetical protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein; PBP [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MPRKISLGLMALFISVQVSVTQQLVKAQTPTAPTPTTKSICPAELGTAIDTIVNRPLFNRVRWGILVKPLSSMQTLYSRD
AEKYFTPASNAKLLTTAAALQQLGADFRIRTSIYQNGNGNFTIVGRGDPSLSDTQLQSLAQQLKQKGITQVNQLIADDSY
IQGDIVNSTWQWEDVQSNYGAPVNSFILNQNVFGLKLIPQIVGKTPQLLWNDPNEARQWLIINQSVTVAANQPSYIDVSR
DLTGKVLRIKGQIAANSTPYLVELPVVDPNYYFLRRFRSALSTEKISLGTTLVASSASNQQELAAVQSPPLSQLLIETNQ
NSNNLYAEALLRALAFKQPRVQNKSTANIGLDVIKVTLNKLGVDPTGYVLIDASGLSRRNLVTPEALVQTLQGIAKTPAA
NVYRASLPIAGKSGTLSNRLRNTPAQGIVQAKTGTLSGAISLSGYVNSSQYEPLAFSIMVNQSEQPASALRQAIDEIVVL
LAQLKRC

Sequences:

>Translated_487_residues
MPRKISLGLMALFISVQVSVTQQLVKAQTPTAPTPTTKSICPAELGTAIDTIVNRPLFNRVRWGILVKPLSSMQTLYSRD
AEKYFTPASNAKLLTTAAALQQLGADFRIRTSIYQNGNGNFTIVGRGDPSLSDTQLQSLAQQLKQKGITQVNQLIADDSY
IQGDIVNSTWQWEDVQSNYGAPVNSFILNQNVFGLKLIPQIVGKTPQLLWNDPNEARQWLIINQSVTVAANQPSYIDVSR
DLTGKVLRIKGQIAANSTPYLVELPVVDPNYYFLRRFRSALSTEKISLGTTLVASSASNQQELAAVQSPPLSQLLIETNQ
NSNNLYAEALLRALAFKQPRVQNKSTANIGLDVIKVTLNKLGVDPTGYVLIDASGLSRRNLVTPEALVQTLQGIAKTPAA
NVYRASLPIAGKSGTLSNRLRNTPAQGIVQAKTGTLSGAISLSGYVNSSQYEPLAFSIMVNQSEQPASALRQAIDEIVVL
LAQLKRC
>Mature_486_residues
PRKISLGLMALFISVQVSVTQQLVKAQTPTAPTPTTKSICPAELGTAIDTIVNRPLFNRVRWGILVKPLSSMQTLYSRDA
EKYFTPASNAKLLTTAAALQQLGADFRIRTSIYQNGNGNFTIVGRGDPSLSDTQLQSLAQQLKQKGITQVNQLIADDSYI
QGDIVNSTWQWEDVQSNYGAPVNSFILNQNVFGLKLIPQIVGKTPQLLWNDPNEARQWLIINQSVTVAANQPSYIDVSRD
LTGKVLRIKGQIAANSTPYLVELPVVDPNYYFLRRFRSALSTEKISLGTTLVASSASNQQELAAVQSPPLSQLLIETNQN
SNNLYAEALLRALAFKQPRVQNKSTANIGLDVIKVTLNKLGVDPTGYVLIDASGLSRRNLVTPEALVQTLQGIAKTPAAN
VYRASLPIAGKSGTLSNRLRNTPAQGIVQAKTGTLSGAISLSGYVNSSQYEPLAFSIMVNQSEQPASALRQAIDEIVVLL
AQLKRC

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG2027

COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S13 family [H]

Homologues:

Organism=Escherichia coli, GI1789573, Length=389, Percent_Identity=28.0205655526992, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR000667 [H]

Pfam domain/function: PF02113 Peptidase_S13 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 52918; Mature: 52787

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKISLGLMALFISVQVSVTQQLVKAQTPTAPTPTTKSICPAELGTAIDTIVNRPLFNR
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
VRWGILVKPLSSMQTLYSRDAEKYFTPASNAKLLTTAAALQQLGADFRIRTSIYQNGNGN
HHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCC
FTIVGRGDPSLSDTQLQSLAQQLKQKGITQVNQLIADDSYIQGDIVNSTWQWEDVQSNYG
EEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCEECCEECCCHHHHCCC
APVNSFILNQNVFGLKLIPQIVGKTPQLLWNDPNEARQWLIINQSVTVAANQPSYIDVSR
CCHHHHEECCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEECEEEEEECCCCEEEECC
DLTGKVLRIKGQIAANSTPYLVELPVVDPNYYFLRRFRSALSTEKISLGTTLVASSASNQ
CCCCEEEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEECCEEEEECCCCCH
QELAAVQSPPLSQLLIETNQNSNNLYAEALLRALAFKQPRVQNKSTANIGLDVIKVTLNK
HHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LGVDPTGYVLIDASGLSRRNLVTPEALVQTLQGIAKTPAANVYRASLPIAGKSGTLSNRL
HCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHH
RNTPAQGIVQAKTGTLSGAISLSGYVNSSQYEPLAFSIMVNQSEQPASALRQAIDEIVVL
HCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LAQLKRC
HHHHHCC
>Mature Secondary Structure 
PRKISLGLMALFISVQVSVTQQLVKAQTPTAPTPTTKSICPAELGTAIDTIVNRPLFNR
CCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
VRWGILVKPLSSMQTLYSRDAEKYFTPASNAKLLTTAAALQQLGADFRIRTSIYQNGNGN
HHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCC
FTIVGRGDPSLSDTQLQSLAQQLKQKGITQVNQLIADDSYIQGDIVNSTWQWEDVQSNYG
EEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCEECCEECCCHHHHCCC
APVNSFILNQNVFGLKLIPQIVGKTPQLLWNDPNEARQWLIINQSVTVAANQPSYIDVSR
CCHHHHEECCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEECEEEEEECCCCEEEECC
DLTGKVLRIKGQIAANSTPYLVELPVVDPNYYFLRRFRSALSTEKISLGTTLVASSASNQ
CCCCEEEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEECCEEEEECCCCCH
QELAAVQSPPLSQLLIETNQNSNNLYAEALLRALAFKQPRVQNKSTANIGLDVIKVTLNK
HHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LGVDPTGYVLIDASGLSRRNLVTPEALVQTLQGIAKTPAANVYRASLPIAGKSGTLSNRL
HCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHH
RNTPAQGIVQAKTGTLSGAISLSGYVNSSQYEPLAFSIMVNQSEQPASALRQAIDEIVVL
HCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LAQLKRC
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1554361; 7305936 [H]