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The map label for this gene is dxs [H]

Identifier: 17228095

GI number: 17228095

Start: 696196

End: 698103

Strand: Direct

Name: dxs [H]

Synonym: alr0599

Alternate gene names: 17228095

Gene position: 696196-698103 (Clockwise)

Preceding gene: 17228094

Following gene: 17228096

Centisome position: 10.85

GC content: 46.59

Gene sequence:

>1908_bases
ATGCATCTGAGTGAAATCACCCATCCCAATCAGCTGCACGGTCTATCCATCCGTCAACTGCAACAAATTGCCCGTCAGAT
TCGAGATAAACACCTGCAAACAGTAGCTGAATTTGGTGGACATCTGGGGCCTGGCTTGGGTGTTGTAGAGTTAACACTAG
GGCTTTACCAGACTCTAGATTTAGACCGGGATAAAGTTATATGGGATGTAGGACACCAAGCTTATCCCCACAAATTGATT
ACAGGACGCTACAGCGACTTCCATACCCTCAGACAAAAAGATGGAATTGCCGGTTATCTCAAACGTGGTGAAAATAAATT
CGATCATTTTGGTGCAGGCCACGCTTCAACCAGCATCTCCGCAGCATTGGGTATGGCTTTAGCACGAGACATGAACGGGG
AAAAGTTTAAAGCCGTGGCCGTGATTGGCGATGGTGCATTAACAGGTGGTATGGCGTTGGAAGCTATCAACCATGCTGGA
CACTTGCCGAAAACCAACTTATTGGTTGTTCTCAACGACAATGAGATGTCTATTTCTCCCAACGTCGGCGCGATTCCTCG
CTACCTCAACAAAATGCGCCTCAGTCCCCCGGTGCAGTTCATCAAGGATAATTTTGAAGAACAGTTCAAACACATTCCCT
TTGTCGGCGAATCCCTATCTCCCGAATTAGGAAGAATTAAAGAAGGGATGAAACGTTTAGCCGTTCCCAAGGTAGGTGCA
GTATTTGAAGAACTGGGCTTTACCTACATGGGGCCAGTTGATGGGCATAATTTAGAGGAATTGATTGCTACCTTCCAACA
AGCACACCAAATAGCTGGGCCAGTGTTAGTTCATGTAGCCACTATCAAAGGTAAGGGCTACGAACTCGCGGAAAAAGACC
AAGTAGGCTACCATGCCCAAACTCCTTTTAACCTGACAACTGGCAAAGCAATTCCCTCCAACAAACCCAAACCCCCTGCT
TATGCCAAAGTCTTCTCCCATACCCTAGTTAAATTAGCAGAACAAAACCCCAAAATTATTGGGATTACTGCGGCTATGGC
GACAGGAACAGGTTTAGATAAGCTACAAGCAAAACTGCCCAATCAATATATTGATGTTGGCATTGCGGAACAACACGCAG
TCACCCTCGCAGCTGGTTTGGCAACTGAAGGTATGCGTCCTGTAGCAGCCATCTACTCTACTTTCTTACAAAGGGCATAC
GACCAGATTATTCACGATGTCTGTATCCAAAATTTACCAGTATTCTTCTGTTTGGATCGGGCGGGAATTGTTGGTTCTGA
TGGCCCTACCCACCAAGGTATGTATGACATTGCCTATCTACGGTGCATTCCCAACATTGTAATGATGGCACCGAAAGATG
AAGCCGAAATGCAACGCATGGTAGTTACTGGTATTGAACATACCACCGGGCCCATCGCTATGCGTTTCCCTCGTGGCAAT
GGCTATGGCGTACCCCTGATGGAAGAAGGCTGGGAACCTTTGGAAATCGGTAAAGGTGAAATTCTCCGCAACGGTGATGA
TGTATTAATTATCGGCTACGGCACAATGGTTTACCCCAGTATGCAGGCGGCGGAAATTCTCAGCGAACACGGGATTGAAG
CGACTGTGATTAATGCCCGATTTGTTAAACCCTTAGATACGGAATTAATCGTGCCTTTGGCTCAGAAAATTGGGCGGGTT
GTCACCCTGGAAGAAGGCTGTGTGATGGGTGGCTTTGGTTCAGCTGTAGCAGAAGCATTGTTAGATGCAGATGTGGTGGT
TCCTGTCAAGCGCATTGGTATTCCTGATGTATTGGTAGAACACGCTACTCCAGATGAGTCTAAGGCGGAATTAGGTTTAA
CTAGCCGTCAAATTGCGGAAAGAGTTCTACAGGCTTACTTTCAAAAGCAACCATCTCCTGTAAGCTAA

Upstream 100 bases:

>100_bases
TCTTAGACTGCTACTTAGTAACAGTCTAATTCTCCGGGCTACCCGACCGTGGGAAAATCAGAATACCAAAAGTAGAGATT
AGAGAGGAAAACCCTATAAT

Downstream 100 bases:

>100_bases
GTTTCTGTTTCACTTGTACGAGGTTCCAAGCCATAATTTATCCGGGGATTACGCAAGTGTCACAAAAAGTCTTATTTTTT
GCTTGTAGTAAGGGCTTTAG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAEFGGHLGPGLGVVELTLGLYQTLDLDRDKVIWDVGHQAYPHKLI
TGRYSDFHTLRQKDGIAGYLKRGENKFDHFGAGHASTSISAALGMALARDMNGEKFKAVAVIGDGALTGGMALEAINHAG
HLPKTNLLVVLNDNEMSISPNVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGA
VFEELGFTYMGPVDGHNLEELIATFQQAHQIAGPVLVHVATIKGKGYELAEKDQVGYHAQTPFNLTTGKAIPSNKPKPPA
YAKVFSHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLPNQYIDVGIAEQHAVTLAAGLATEGMRPVAAIYSTFLQRAY
DQIIHDVCIQNLPVFFCLDRAGIVGSDGPTHQGMYDIAYLRCIPNIVMMAPKDEAEMQRMVVTGIEHTTGPIAMRFPRGN
GYGVPLMEEGWEPLEIGKGEILRNGDDVLIIGYGTMVYPSMQAAEILSEHGIEATVINARFVKPLDTELIVPLAQKIGRV
VTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGIPDVLVEHATPDESKAELGLTSRQIAERVLQAYFQKQPSPVS

Sequences:

>Translated_635_residues
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAEFGGHLGPGLGVVELTLGLYQTLDLDRDKVIWDVGHQAYPHKLI
TGRYSDFHTLRQKDGIAGYLKRGENKFDHFGAGHASTSISAALGMALARDMNGEKFKAVAVIGDGALTGGMALEAINHAG
HLPKTNLLVVLNDNEMSISPNVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGA
VFEELGFTYMGPVDGHNLEELIATFQQAHQIAGPVLVHVATIKGKGYELAEKDQVGYHAQTPFNLTTGKAIPSNKPKPPA
YAKVFSHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLPNQYIDVGIAEQHAVTLAAGLATEGMRPVAAIYSTFLQRAY
DQIIHDVCIQNLPVFFCLDRAGIVGSDGPTHQGMYDIAYLRCIPNIVMMAPKDEAEMQRMVVTGIEHTTGPIAMRFPRGN
GYGVPLMEEGWEPLEIGKGEILRNGDDVLIIGYGTMVYPSMQAAEILSEHGIEATVINARFVKPLDTELIVPLAQKIGRV
VTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGIPDVLVEHATPDESKAELGLTSRQIAERVLQAYFQKQPSPVS
>Mature_635_residues
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAEFGGHLGPGLGVVELTLGLYQTLDLDRDKVIWDVGHQAYPHKLI
TGRYSDFHTLRQKDGIAGYLKRGENKFDHFGAGHASTSISAALGMALARDMNGEKFKAVAVIGDGALTGGMALEAINHAG
HLPKTNLLVVLNDNEMSISPNVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGA
VFEELGFTYMGPVDGHNLEELIATFQQAHQIAGPVLVHVATIKGKGYELAEKDQVGYHAQTPFNLTTGKAIPSNKPKPPA
YAKVFSHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLPNQYIDVGIAEQHAVTLAAGLATEGMRPVAAIYSTFLQRAY
DQIIHDVCIQNLPVFFCLDRAGIVGSDGPTHQGMYDIAYLRCIPNIVMMAPKDEAEMQRMVVTGIEHTTGPIAMRFPRGN
GYGVPLMEEGWEPLEIGKGEILRNGDDVLIIGYGTMVYPSMQAAEILSEHGIEATVINARFVKPLDTELIVPLAQKIGRV
VTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGIPDVLVEHATPDESKAELGLTSRQIAERVLQAYFQKQPSPVS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=537, Percent_Identity=24.0223463687151, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4507521, Length=537, Percent_Identity=24.0223463687151, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI133778974, Length=627, Percent_Identity=23.9234449760766, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI225637459, Length=390, Percent_Identity=28.974358974359, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637461, Length=390, Percent_Identity=28.974358974359, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637463, Length=390, Percent_Identity=28.974358974359, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI156564403, Length=268, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI291084858, Length=260, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=44.8387096774194, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788808, Length=248, Percent_Identity=25.8064516129032, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=435, Percent_Identity=30.8045977011494, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17538422, Length=237, Percent_Identity=26.1603375527426, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=256, Percent_Identity=25.390625, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551847, Length=676, Percent_Identity=26.4792899408284, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45550715, Length=676, Percent_Identity=26.4792899408284, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645119, Length=631, Percent_Identity=26.7828843106181, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24666278, Length=642, Percent_Identity=25.8566978193146, Blast_Score=143, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21358145, Length=265, Percent_Identity=25.6603773584906, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650940, Length=265, Percent_Identity=25.6603773584906, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI160714832, Length=281, Percent_Identity=24.1992882562278, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI160714828, Length=281, Percent_Identity=24.1992882562278, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69023; Mature: 69023

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAEFGGHLGPGLGVVELTLGLYQTLD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
LDRDKVIWDVGHQAYPHKLITGRYSDFHTLRQKDGIAGYLKRGENKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHCCCCCHHHCCCCCCHHHHH
AALGMALARDMNGEKFKAVAVIGDGALTGGMALEAINHAGHLPKTNLLVVLNDNEMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEECC
NVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGA
CCCHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPVDGHNLEELIATFQQAHQIAGPVLVHVATIKGKGYELAEKDQVGYHAQ
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEECC
TPFNLTTGKAIPSNKPKPPAYAKVFSHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHCC
NQYIDVGIAEQHAVTLAAGLATEGMRPVAAIYSTFLQRAYDQIIHDVCIQNLPVFFCLDR
CHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGIVGSDGPTHQGMYDIAYLRCIPNIVMMAPKDEAEMQRMVVTGIEHTTGPIAMRFPRGN
CCCCCCCCCCCCCHHHHHHHHHHCHHEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCC
GYGVPLMEEGWEPLEIGKGEILRNGDDVLIIGYGTMVYPSMQAAEILSEHGIEATVINAR
CCCCCHHHCCCCCCCCCCCCEEECCCCEEEEEECHHHCCCHHHHHHHHHCCCEEEEEECE
FVKPLDTELIVPLAQKIGRVVTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGIPDVLVE
ECCCCCHHHHHHHHHHCCCEEEECCCCEECCHHHHHHHHHHCCCCEEEHHHCCCCHHHHH
HATPDESKAELGLTSRQIAERVLQAYFQKQPSPVS
CCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAEFGGHLGPGLGVVELTLGLYQTLD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
LDRDKVIWDVGHQAYPHKLITGRYSDFHTLRQKDGIAGYLKRGENKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHCCCCCHHHCCCCCCHHHHH
AALGMALARDMNGEKFKAVAVIGDGALTGGMALEAINHAGHLPKTNLLVVLNDNEMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEECC
NVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGA
CCCHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPVDGHNLEELIATFQQAHQIAGPVLVHVATIKGKGYELAEKDQVGYHAQ
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEECC
TPFNLTTGKAIPSNKPKPPAYAKVFSHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHCC
NQYIDVGIAEQHAVTLAAGLATEGMRPVAAIYSTFLQRAYDQIIHDVCIQNLPVFFCLDR
CHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGIVGSDGPTHQGMYDIAYLRCIPNIVMMAPKDEAEMQRMVVTGIEHTTGPIAMRFPRGN
CCCCCCCCCCCCCHHHHHHHHHHCHHEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCC
GYGVPLMEEGWEPLEIGKGEILRNGDDVLIIGYGTMVYPSMQAAEILSEHGIEATVINAR
CCCCCHHHCCCCCCCCCCCCEEECCCCEEEEEECHHHCCCHHHHHHHHHCCCEEEEEECE
FVKPLDTELIVPLAQKIGRVVTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGIPDVLVE
ECCCCCHHHHHHHHHHCCCEEEECCCCEECCHHHHHHHHHHCCCCEEEHHHCCCCHHHHH
HATPDESKAELGLTSRQIAERVLQAYFQKQPSPVS
CCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA