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The map label for this gene is cvrA [H]

Identifier: 17227748

GI number: 17227748

Start: 271108

End: 272997

Strand: Direct

Name: cvrA [H]

Synonym: alr0252

Alternate gene names: 17227748

Gene position: 271108-272997 (Clockwise)

Preceding gene: 17227745

Following gene: 17227751

Centisome position: 4.23

GC content: 45.61

Gene sequence:

>1890_bases
ATGGAAGCATCATTTGAAGTCACCCTACAGATGGCGATCGCTGTTTTTGCAGGTATCGGCGCTCAAGTCCTAGCGGCTTA
TTTGCGTGTACCCAGCATCGTCATATTGCTGTTGTTGGGCATTTTGCTAGGTGGTGATGGGGTTGGGTTATTACATCCCC
AATTACTCGGTACAGGGCTGGAAGTGATTGTTGCCCTAGCAACGGCAATCATTCTGTTTGAAGGTGGATTGAATTTAGAT
TTACGCGAATTAGGTAGAGTTTCCCTCAGCTTGCAACGGCTTGTCACCTTAGGGACGCTAATCACCCTCATTGGGGGTAG
TATGGCCGCCCATTGGCTGGGTGAATTTCCTTGGAATATAGCTTTTCTCTACGCTTCTATTGTTGTGGTCACAGGGCCGA
CTGTCATCAGTCCCCTGCTCAAACAAATCAACGTAGACCGGCAAGTGGCGACGTTGTTAGAAGGTGAGGGAGTTCTTATC
GACCCAGTGGGAGCTATTTTAGCTTTTGTGGTGCTAGACACTATCGTTAACGGTGATGCAGACCCAGTAAAAGCCATTAT
CGGTTTAATAATGCGGTTGGGTATTGGTGCAGCCATAGGTGCTGCTGGCGGGTATTTCATGAGTTTGATTTTCAAGCGCG
CCAATTTCCTTTCGTCTGAGTTAAAAAATCTAGTGGTTTTGGCTGTGCTATGGAGTTTATTTACTCTAGCGCAGATGATT
CGCAGTGAATCGGGTGTGATGACAACTGTCATCGCTGGGGCAGTATTCGCTAACTCTTCAGTACCAGAGGAACGTTCCTT
ACGCAGCTTCAAAGGTCAACTGACAATTTTGAGCGTTTCTGTACTGTTCATTCTGTTAGCAGCTGATTTATCCATTGCCA
GCGTGTTTGCTTTGGGTTGGGGCAGCTTGTTTACTGTATTGGTCTTGATGTTTGTTGTTCGCCCTGTAAATATCTTGTTC
TGCACTTGGAACAGTAACTTAAACTGGCGACAGAAACTATTTTTAAGCTGGGTTGCACCTAGAGGGATTGTTTCTGCCTC
TGTTGCGCCCTTGTTTGCAATTTTGCTAACTCAGCGTGGGGTCAATGGCGGTGATTCTATCAAAGCTTTGGTTTTCCTCA
CTATTATCATGACGGTAGTTTGTCAAGGATTAACAGCTGGTTGGGTGGCGAAATTTTTGGGCATCACTTCCCAAGAAGCT
ACAGGTGCAGTAATTGTCGGTTGTAATCCTTTGAGTTTGTTAATCGCCCGGTTCTTTCAAGAACGGGGGGAAAATGTCGT
CTTAATTGATACTGATCCAGATTATATTGCTCAAGCAGAAACGCAAAATCTGCGGGTGATTGCTAGCAGTGCGCTGGATG
GAGAGGTATTAGAAGAGGCGGGACTGGCATCGATGGGAACTTTTTTGGCGATGACGAGTAATGGTGAAGTAAACTTCGTT
TTAGCCGAAAGGGCAGCCGAGGAATTTAATCCGCCCCGTGTTTTGGCTGTTTTTCCCCGCGATCCTCAGGCGAATGGTTC
GGCCAATAATAAAGTCCAACAAGCTTTTGTTTCTGATTTGCCCATTAAGACTTGGAACGAATATCTCAATGATGGACGGG
TGAAGTTAGGCACAACTACCTTGAGCGAATCGGAGTTTGCTAGCCAACAGGAACATATTCAAGAGAAAATTCGGAATGGG
GTGTTAGTACCGTTGTTAGTAGAAAGGGAAGAACGCTTACAAATTATCCCAGCTAACCAAGAATGGGAAGTAGGCGATCG
CATTATCTACCTATTACATGACCCCAGACCGAACTTATTAAAACGCTTATCCGGTGCTAGTCAATCCACACCTCTAGTTT
TAGAGACGTTACCAGAGGTGGAAGAAGTACCTTTAGCAAAGGTGCTTTAA

Upstream 100 bases:

>100_bases
AATTCATTGAGGTATAAACTGTCTGATGTTGTAACCTGTAAAGATGATATTTACTTTTCTTTACAAAGGATTTTGAAAGA
AATCGCTCAAAATCTAAAAC

Downstream 100 bases:

>100_bases
ACTTCAGCTAGTGACGCTTGCTTGTGTGAGTTGAATAATTTCCTCTCTCGTTTCTGCGTACATTTCTCGTTCTTGCCACA
ATAAGGCTGACAAATGTACC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MEASFEVTLQMAIAVFAGIGAQVLAAYLRVPSIVILLLLGILLGGDGVGLLHPQLLGTGLEVIVALATAIILFEGGLNLD
LRELGRVSLSLQRLVTLGTLITLIGGSMAAHWLGEFPWNIAFLYASIVVVTGPTVISPLLKQINVDRQVATLLEGEGVLI
DPVGAILAFVVLDTIVNGDADPVKAIIGLIMRLGIGAAIGAAGGYFMSLIFKRANFLSSELKNLVVLAVLWSLFTLAQMI
RSESGVMTTVIAGAVFANSSVPEERSLRSFKGQLTILSVSVLFILLAADLSIASVFALGWGSLFTVLVLMFVVRPVNILF
CTWNSNLNWRQKLFLSWVAPRGIVSASVAPLFAILLTQRGVNGGDSIKALVFLTIIMTVVCQGLTAGWVAKFLGITSQEA
TGAVIVGCNPLSLLIARFFQERGENVVLIDTDPDYIAQAETQNLRVIASSALDGEVLEEAGLASMGTFLAMTSNGEVNFV
LAERAAEEFNPPRVLAVFPRDPQANGSANNKVQQAFVSDLPIKTWNEYLNDGRVKLGTTTLSESEFASQQEHIQEKIRNG
VLVPLLVEREERLQIIPANQEWEVGDRIIYLLHDPRPNLLKRLSGASQSTPLVLETLPEVEEVPLAKVL

Sequences:

>Translated_629_residues
MEASFEVTLQMAIAVFAGIGAQVLAAYLRVPSIVILLLLGILLGGDGVGLLHPQLLGTGLEVIVALATAIILFEGGLNLD
LRELGRVSLSLQRLVTLGTLITLIGGSMAAHWLGEFPWNIAFLYASIVVVTGPTVISPLLKQINVDRQVATLLEGEGVLI
DPVGAILAFVVLDTIVNGDADPVKAIIGLIMRLGIGAAIGAAGGYFMSLIFKRANFLSSELKNLVVLAVLWSLFTLAQMI
RSESGVMTTVIAGAVFANSSVPEERSLRSFKGQLTILSVSVLFILLAADLSIASVFALGWGSLFTVLVLMFVVRPVNILF
CTWNSNLNWRQKLFLSWVAPRGIVSASVAPLFAILLTQRGVNGGDSIKALVFLTIIMTVVCQGLTAGWVAKFLGITSQEA
TGAVIVGCNPLSLLIARFFQERGENVVLIDTDPDYIAQAETQNLRVIASSALDGEVLEEAGLASMGTFLAMTSNGEVNFV
LAERAAEEFNPPRVLAVFPRDPQANGSANNKVQQAFVSDLPIKTWNEYLNDGRVKLGTTTLSESEFASQQEHIQEKIRNG
VLVPLLVEREERLQIIPANQEWEVGDRIIYLLHDPRPNLLKRLSGASQSTPLVLETLPEVEEVPLAKVL
>Mature_629_residues
MEASFEVTLQMAIAVFAGIGAQVLAAYLRVPSIVILLLLGILLGGDGVGLLHPQLLGTGLEVIVALATAIILFEGGLNLD
LRELGRVSLSLQRLVTLGTLITLIGGSMAAHWLGEFPWNIAFLYASIVVVTGPTVISPLLKQINVDRQVATLLEGEGVLI
DPVGAILAFVVLDTIVNGDADPVKAIIGLIMRLGIGAAIGAAGGYFMSLIFKRANFLSSELKNLVVLAVLWSLFTLAQMI
RSESGVMTTVIAGAVFANSSVPEERSLRSFKGQLTILSVSVLFILLAADLSIASVFALGWGSLFTVLVLMFVVRPVNILF
CTWNSNLNWRQKLFLSWVAPRGIVSASVAPLFAILLTQRGVNGGDSIKALVFLTIIMTVVCQGLTAGWVAKFLGITSQEA
TGAVIVGCNPLSLLIARFFQERGENVVLIDTDPDYIAQAETQNLRVIASSALDGEVLEEAGLASMGTFLAMTSNGEVNFV
LAERAAEEFNPPRVLAVFPRDPQANGSANNKVQQAFVSDLPIKTWNEYLNDGRVKLGTTTLSESEFASQQEHIQEKIRNG
VLVPLLVEREERLQIIPANQEWEVGDRIIYLLHDPRPNLLKRLSGASQSTPLVLETLPEVEEVPLAKVL

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 67592; Mature: 67592

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEASFEVTLQMAIAVFAGIGAQVLAAYLRVPSIVILLLLGILLGGDGVGLLHPQLLGTGL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EVIVALATAIILFEGGLNLDLRELGRVSLSLQRLVTLGTLITLIGGSMAAHWLGEFPWNI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
AFLYASIVVVTGPTVISPLLKQINVDRQVATLLEGEGVLIDPVGAILAFVVLDTIVNGDA
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCC
DPVKAIIGLIMRLGIGAAIGAAGGYFMSLIFKRANFLSSELKNLVVLAVLWSLFTLAQMI
HHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSESGVMTTVIAGAVFANSSVPEERSLRSFKGQLTILSVSVLFILLAADLSIASVFALGW
HCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLFTVLVLMFVVRPVNILFCTWNSNLNWRQKLFLSWVAPRGIVSASVAPLFAILLTQRG
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
VNGGDSIKALVFLTIIMTVVCQGLTAGWVAKFLGITSQEATGAVIVGCNPLSLLIARFFQ
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHH
ERGENVVLIDTDPDYIAQAETQNLRVIASSALDGEVLEEAGLASMGTFLAMTSNGEVNFV
HHCCEEEEEECCCCHHHHCCCCCEEEEECCCCCHHHHHHCCCHHHCCEEEEECCCCEEEE
LAERAAEEFNPPRVLAVFPRDPQANGSANNKVQQAFVSDLPIKTWNEYLNDGRVKLGTTT
EEHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEE
LSESEFASQQEHIQEKIRNGVLVPLLVEREERLQIIPANQEWEVGDRIIYLLHDPRPNLL
CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCHHHH
KRLSGASQSTPLVLETLPEVEEVPLAKVL
HHHCCCCCCCCCHHHHCCCHHHCCHHHCC
>Mature Secondary Structure
MEASFEVTLQMAIAVFAGIGAQVLAAYLRVPSIVILLLLGILLGGDGVGLLHPQLLGTGL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EVIVALATAIILFEGGLNLDLRELGRVSLSLQRLVTLGTLITLIGGSMAAHWLGEFPWNI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
AFLYASIVVVTGPTVISPLLKQINVDRQVATLLEGEGVLIDPVGAILAFVVLDTIVNGDA
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCC
DPVKAIIGLIMRLGIGAAIGAAGGYFMSLIFKRANFLSSELKNLVVLAVLWSLFTLAQMI
HHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSESGVMTTVIAGAVFANSSVPEERSLRSFKGQLTILSVSVLFILLAADLSIASVFALGW
HCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLFTVLVLMFVVRPVNILFCTWNSNLNWRQKLFLSWVAPRGIVSASVAPLFAILLTQRG
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
VNGGDSIKALVFLTIIMTVVCQGLTAGWVAKFLGITSQEATGAVIVGCNPLSLLIARFFQ
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHH
ERGENVVLIDTDPDYIAQAETQNLRVIASSALDGEVLEEAGLASMGTFLAMTSNGEVNFV
HHCCEEEEEECCCCHHHHCCCCCEEEEECCCCCHHHHHHCCCHHHCCEEEEECCCCEEEE
LAERAAEEFNPPRVLAVFPRDPQANGSANNKVQQAFVSDLPIKTWNEYLNDGRVKLGTTT
EEHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEE
LSESEFASQQEHIQEKIRNGVLVPLLVEREERLQIIPANQEWEVGDRIIYLLHDPRPNLL
CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCHHHH
KRLSGASQSTPLVLETLPEVEEVPLAKVL
HHHCCCCCCCCCHHHHCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA