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The map label for this gene is lytC [H]

Identifier: 17227589

GI number: 17227589

Start: 97350

End: 99233

Strand: Direct

Name: lytC [H]

Synonym: alr0093

Alternate gene names: 17227589

Gene position: 97350-99233 (Clockwise)

Preceding gene: 17227588

Following gene: 17227590

Centisome position: 1.52

GC content: 45.22

Gene sequence:

>1884_bases
GTGAAATTACACTGGTTACTATCCGGTACGGTTGGAACCATCTTCTTACTATCGTCACCAGCTTTAGCAGCAAGGCTAGA
CTCTTGGCGATTTGACCCTAGCCAAAATCGTTTAGAGATTAATACTAATGGCGCTGTACAACCCAAGGCGCAACTGATTT
TCAATCCGACACGTTTAGTTATTGATTTACCCGAAACCACATTTGGTCAGCCCCCATCAACACAGCAAATAGGCGGTGCA
ATTCGGGCTATACGTGTAGGACAATTTGATCCACAGACCACGCGTATTGTCGTAGAACTCAATCCTGGTTACACACTCGA
CCCCCAACAAGTCAAATTTGTCGGTATCAGCCCTAGTCGCTGGACTGTGCAGCTACCTACCCCAACAGTTGAAAGAGTCG
CATCGCCCAGAGAAACTGCACAGCAGCCAGTACCTACCATTCCCTCAGAAACCGGAGTGGACACACCCTCGGTTTTATCA
CCCAGAAATGTTTACTCTGTCACTCCAACTACCAAGGAAGCACCGATTAGTAATCTTGCATCTGTAACTCAAATTGATAA
CTTACGAGTTACAGGCGATGGATTTTTTATCCGTACCCGTGGTGCTACCCCCCAAATTCAAGTTAATCGTACAGATGATA
ATCGGGTAATTAATATCAACATTACCGGCGCATCTTTATCGCCAAACATCGAGAGAGATTTATCAATTAATCGTTATGGT
GTCAGCAGCATCCAATTGACGCAATTGTCAACGCAAACTGTACGTATCTCCATGCAGGTGGATAGCAACAGTCCTGACTG
GCGAGTTAGTACTAGCAGCGTTGGTGGGTTTGTGCTTCTCCCCAGTAAAGGTATTGCCAACTTACCCCAAAATAATACTC
CCAACACCATTTCATCCAATACCAACTCACCCGCCACCATTCAAGCGGTGGAACTAGGTGATAATGGTACACAACTTTTA
ATTCGCTCTGACCAAGCAGTAACAGCTAAAGGCGGCTGGGACAGAACCTCTGGACTTTACCGCATCATTATTAATAACGC
CAAGTTATCTCCTAGAGTTACAGGCCCAGCTTTTAATGCTAACAGCCCTATTCTCCGTGTCCGTCTGCAACCCCAAGTAG
CCAATACAGTAGTTGTTTTGGTACAACCAGCAGCCGGAGTACAAATAGGGGAACTCAATCAAGTAAGTAACCAAATTTTA
GCTCTAGAATTACAATCTTCTCGGCAATTGATACCACCAGTAGGTTTACCACCCCTACCATCAACAAATCGTAGTCAATT
GCCAAATCCAAATATCGATAATCCCATAAATATCCCACAACCAATACCCAGGTCAGTTCCCAGGGGAAGACTTTTAGTCG
TCATCGACCCTGGACATGGTGGTAAAGATTCTGGCGCTCCTGGTTTGGGTGGATTACTAGAAAAAGATGTAGTCCTACCT
ATCGGTTTAAGAATAGCCGCTATTTTAGAGCAGAATGGTATCCAAGCAGTCTTGACGCGCGATGCAGATTTTTTTGTGGA
GTTACAAGGACGGGTAGATATTGCCGAACGAGCTAACGCGACTTTGTTTGTCAGTATTCACGCCAACTCCGTAGAAGGCC
GCCCTGATGTTAATGGCTTGGAAGTATATTACTACGATAGTGGTTATGCTTTAGCCGAATCAGTCCGCAAGACTATTCTC
CAAAGTATTGGCACACTCAAAGACCGAGGCACACGCAAAGCTCGGTTCTACGTCTTGAGGAAGAGTTCTATGCCGTCGAT
TCTAGTAGAAACAGGTTATATGAGTGGTAGGGAAGATAATCCCAGACTAGGCTCACCAGAATACCAAAATCGCATGGCAG
ATGCGATCGCTCGTGGTATCCTGCAATATTTAAAGAGACAGTAA

Upstream 100 bases:

>100_bases
TATTGCAGTAAAGCTGAAGTTTGAACGGTGATGGTGTGAGGATTAGCCAACATTTTGGAGCCTTAACGGCTCTCATGAAC
GCACATCAGGAGAAAAGATT

Downstream 100 bases:

>100_bases
AATTTTCATTAAGTTCAACATTTAGTCTCAATTACTCACTCTAGAGGTGGTATGTAAACTGCGTGTAGATACAGAATTTA
GTAGTCAATTGGTAAATTGT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MKLHWLLSGTVGTIFLLSSPALAARLDSWRFDPSQNRLEINTNGAVQPKAQLIFNPTRLVIDLPETTFGQPPSTQQIGGA
IRAIRVGQFDPQTTRIVVELNPGYTLDPQQVKFVGISPSRWTVQLPTPTVERVASPRETAQQPVPTIPSETGVDTPSVLS
PRNVYSVTPTTKEAPISNLASVTQIDNLRVTGDGFFIRTRGATPQIQVNRTDDNRVININITGASLSPNIERDLSINRYG
VSSIQLTQLSTQTVRISMQVDSNSPDWRVSTSSVGGFVLLPSKGIANLPQNNTPNTISSNTNSPATIQAVELGDNGTQLL
IRSDQAVTAKGGWDRTSGLYRIIINNAKLSPRVTGPAFNANSPILRVRLQPQVANTVVVLVQPAAGVQIGELNQVSNQIL
ALELQSSRQLIPPVGLPPLPSTNRSQLPNPNIDNPINIPQPIPRSVPRGRLLVVIDPGHGGKDSGAPGLGGLLEKDVVLP
IGLRIAAILEQNGIQAVLTRDADFFVELQGRVDIAERANATLFVSIHANSVEGRPDVNGLEVYYYDSGYALAESVRKTIL
QSIGTLKDRGTRKARFYVLRKSSMPSILVETGYMSGREDNPRLGSPEYQNRMADAIARGILQYLKRQ

Sequences:

>Translated_627_residues
MKLHWLLSGTVGTIFLLSSPALAARLDSWRFDPSQNRLEINTNGAVQPKAQLIFNPTRLVIDLPETTFGQPPSTQQIGGA
IRAIRVGQFDPQTTRIVVELNPGYTLDPQQVKFVGISPSRWTVQLPTPTVERVASPRETAQQPVPTIPSETGVDTPSVLS
PRNVYSVTPTTKEAPISNLASVTQIDNLRVTGDGFFIRTRGATPQIQVNRTDDNRVININITGASLSPNIERDLSINRYG
VSSIQLTQLSTQTVRISMQVDSNSPDWRVSTSSVGGFVLLPSKGIANLPQNNTPNTISSNTNSPATIQAVELGDNGTQLL
IRSDQAVTAKGGWDRTSGLYRIIINNAKLSPRVTGPAFNANSPILRVRLQPQVANTVVVLVQPAAGVQIGELNQVSNQIL
ALELQSSRQLIPPVGLPPLPSTNRSQLPNPNIDNPINIPQPIPRSVPRGRLLVVIDPGHGGKDSGAPGLGGLLEKDVVLP
IGLRIAAILEQNGIQAVLTRDADFFVELQGRVDIAERANATLFVSIHANSVEGRPDVNGLEVYYYDSGYALAESVRKTIL
QSIGTLKDRGTRKARFYVLRKSSMPSILVETGYMSGREDNPRLGSPEYQNRMADAIARGILQYLKRQ
>Mature_627_residues
MKLHWLLSGTVGTIFLLSSPALAARLDSWRFDPSQNRLEINTNGAVQPKAQLIFNPTRLVIDLPETTFGQPPSTQQIGGA
IRAIRVGQFDPQTTRIVVELNPGYTLDPQQVKFVGISPSRWTVQLPTPTVERVASPRETAQQPVPTIPSETGVDTPSVLS
PRNVYSVTPTTKEAPISNLASVTQIDNLRVTGDGFFIRTRGATPQIQVNRTDDNRVININITGASLSPNIERDLSINRYG
VSSIQLTQLSTQTVRISMQVDSNSPDWRVSTSSVGGFVLLPSKGIANLPQNNTPNTISSNTNSPATIQAVELGDNGTQLL
IRSDQAVTAKGGWDRTSGLYRIIINNAKLSPRVTGPAFNANSPILRVRLQPQVANTVVVLVQPAAGVQIGELNQVSNQIL
ALELQSSRQLIPPVGLPPLPSTNRSQLPNPNIDNPINIPQPIPRSVPRGRLLVVIDPGHGGKDSGAPGLGGLLEKDVVLP
IGLRIAAILEQNGIQAVLTRDADFFVELQGRVDIAERANATLFVSIHANSVEGRPDVNGLEVYYYDSGYALAESVRKTIL
QSIGTLKDRGTRKARFYVLRKSSMPSILVETGYMSGREDNPRLGSPEYQNRMADAIARGILQYLKRQ

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=271, Percent_Identity=30.9963099630996, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790611, Length=226, Percent_Identity=30.5309734513274, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082163, Length=232, Percent_Identity=31.4655172413793, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 67995; Mature: 67995

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHWLLSGTVGTIFLLSSPALAARLDSWRFDPSQNRLEINTNGAVQPKAQLIFNPTRLV
CEEEEEEECCCEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEECCEEEE
IDLPETTFGQPPSTQQIGGAIRAIRVGQFDPQTTRIVVELNPGYTLDPQQVKFVGISPSR
EECCCCCCCCCCCHHHHCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCC
WTVQLPTPTVERVASPRETAQQPVPTIPSETGVDTPSVLSPRNVYSVTPTTKEAPISNLA
EEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
SVTQIDNLRVTGDGFFIRTRGATPQIQVNRTDDNRVININITGASLSPNIERDLSINRYG
HHEEECCEEEECCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEEC
VSSIQLTQLSTQTVRISMQVDSNSPDWRVSTSSVGGFVLLPSKGIANLPQNNTPNTISSN
CCEEEEEEEEEEEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCC
TNSPATIQAVELGDNGTQLLIRSDQAVTAKGGWDRTSGLYRIIINNAKLSPRVTGPAFNA
CCCCEEEEEEEECCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCEECCCCCCC
NSPILRVRLQPQVANTVVVLVQPAAGVQIGELNQVSNQILALELQSSRQLIPPVGLPPLP
CCCEEEEEECCCCCCEEEEEEECCCCCEECCHHHHCCEEEEEEECCCCCCCCCCCCCCCC
STNRSQLPNPNIDNPINIPQPIPRSVPRGRLLVVIDPGHGGKDSGAPGLGGLLEKDVVLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCEEEE
IGLRIAAILEQNGIQAVLTRDADFFVELQGRVDIAERANATLFVSIHANSVEGRPDVNGL
CCCEEEEEECCCCCEEEEECCCEEEEEEECCEEEHHCCCCEEEEEEECCCCCCCCCCCCE
EVYYYDSGYALAESVRKTILQSIGTLKDRGTRKARFYVLRKSSMPSILVETGYMSGREDN
EEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECCCCCEEEEEECCCCCCCCC
PRLGSPEYQNRMADAIARGILQYLKRQ
CCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLHWLLSGTVGTIFLLSSPALAARLDSWRFDPSQNRLEINTNGAVQPKAQLIFNPTRLV
CEEEEEEECCCEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEECCEEEE
IDLPETTFGQPPSTQQIGGAIRAIRVGQFDPQTTRIVVELNPGYTLDPQQVKFVGISPSR
EECCCCCCCCCCCHHHHCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCC
WTVQLPTPTVERVASPRETAQQPVPTIPSETGVDTPSVLSPRNVYSVTPTTKEAPISNLA
EEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
SVTQIDNLRVTGDGFFIRTRGATPQIQVNRTDDNRVININITGASLSPNIERDLSINRYG
HHEEECCEEEECCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEEC
VSSIQLTQLSTQTVRISMQVDSNSPDWRVSTSSVGGFVLLPSKGIANLPQNNTPNTISSN
CCEEEEEEEEEEEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCC
TNSPATIQAVELGDNGTQLLIRSDQAVTAKGGWDRTSGLYRIIINNAKLSPRVTGPAFNA
CCCCEEEEEEEECCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCEECCCCCCC
NSPILRVRLQPQVANTVVVLVQPAAGVQIGELNQVSNQILALELQSSRQLIPPVGLPPLP
CCCEEEEEECCCCCCEEEEEEECCCCCEECCHHHHCCEEEEEEECCCCCCCCCCCCCCCC
STNRSQLPNPNIDNPINIPQPIPRSVPRGRLLVVIDPGHGGKDSGAPGLGGLLEKDVVLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCEEEE
IGLRIAAILEQNGIQAVLTRDADFFVELQGRVDIAERANATLFVSIHANSVEGRPDVNGL
CCCEEEEEECCCCCEEEEECCCEEEEEEECCEEEHHCCCCEEEEEEECCCCCCCCCCCCE
EVYYYDSGYALAESVRKTILQSIGTLKDRGTRKARFYVLRKSSMPSILVETGYMSGREDN
EEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECCCCCEEEEEECCCCCCCCC
PRLGSPEYQNRMADAIARGILQYLKRQ
CCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]