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The map label for this gene is lytC [H]

Identifier: 17227588

GI number: 17227588

Start: 95168

End: 97051

Strand: Direct

Name: lytC [H]

Synonym: alr0092

Alternate gene names: 17227588

Gene position: 95168-97051 (Clockwise)

Preceding gene: 17227587

Following gene: 17227589

Centisome position: 1.48

GC content: 46.66

Gene sequence:

>1884_bases
GTGAAATTACACTGGTTACTATCTGGTACAGTTGGAACTGTCTTATTACTATCGTCGCCAGCCTTAGCAACGAGGTTAAA
TTCTTGGCGCTTTGATGCCAATCAAAACCGCTTGGAAATTAATACTACAGGTGCCGTCCAACCAAGGGCGCAACTAATTT
TTAATCCCACACGGTTAGTAATAGATTTGCCAAATGTGACATTTGGGCGATCGCAGTTAACACAACCAATCGGTGGTAGA
ATCCGCTCTGTCCGCGTAGGGCAATTTGATCCGCAAACCACGCGTATAGTTGTGGAAGTGGCTCCTGGTTACACTCTTGA
TCCTCAGCAAATCAAATTTGTCGGGCTTACAGCTAACCGTTGGACAGTCCAGTTACCAACTCCCACATCAGAGCAAGCAG
AGTCTTCACCAGACAACACTTATAATGTGGTGACTATTGACTCCAACACCAGGCCAAGTTTACCCAATAACACAAGACCG
GAGTTACCAAATAATACAAGACCAGAGTTCTCCGATAATACAATCAGTGCTGCACCCGGAACGACACAAATTGAAGGCTT
ACAGGTGACTGGGGATGGTTTTTTTGTCCGCACCAGTGGTGGCAATCCTCAAGTTCAAGTCATTCGCAGCCGCGATCGCG
CTACTATTTTTATGGATATTGCTGGGGCAACTTTATCGCCACGCGCCCCAAGAAACATACCCGTTAATAAACATGGTGTC
AACCGGGTTGAACTCACTCCATTACAAACCAGAACCCCAAGCGTCCGTATGACCTTGCGGGTAGATAAGAATAGCCCAGA
CTGGCGAGCAACTAACAGTAATGCAGGTGGTTTAGTAGTTCTACCTAGTCGTGTAGTCAGACTGCCCAATAATGACAACG
GCGAAGGTAACACCTCGACCTTGCCTGACAGAATAACTACAACCAGTGCCATTGCCACAATTCAGTCAGTTGACCTCTCT
AGTAATGGCACACAACTACTGATTAGAGCTGATCAAGCAGTATCTGGTAACGGTGGATGGGATAGAAACACTGGTCTATT
CCGCATCACTATTCCTAACGCCCAGTTAGCTCCCCAAGTCACTGGGCCAAGTTTAAGTGCTAATAGCCCCATTCTCAGAA
TACGTCTGCAAAAACAAGAACCCAACACAGTAGTTGTTCTCGTCCAGCCGGCTGCTGGGGTGCAAGTTGGTCAACTCAAC
AAAGTTGGCAACCAGCTTTTAGCTCTACAATTACAAGGCTCACGTCGGCTCGCTACCACACCTCCCTTACCCCCCATCCA
AGGACAATTACCAGATCCAACAAATCCCCGTCCTCTACCCCAACCAGGAACAAGACCAGTTCCCAAAGGCAGATTATCAG
TATTCATCGACCCCGGACACGGTGGTAAAGACCCAGGAGCCATTGGTATTGGTGGAGTGCGGGAAAAAGATATCATCTTG
CCCATCAGTCAAAGAATTGCCCAAGTATTACAGCAAAATGGGGTACAAGTGGTGATGGCAAGAAATTCTGACTTTTTTGT
CAGCCTACCAGGACGAGTACAAATGGCAGAACGAGCCAGGGCTGATGTATTTGTCAGTATCCACGCTAACGCCATCGGTG
GGAATCGTGCAGATGTCAATGGTTTGGAAACTTACTATTACGATAGCGGATTAGGTTTAGCTCGTGCAGTTCATAGGAGC
ATTCTTCAAAACGTAAATGTCCGAGATAGAGGAGTACGTCGAGCCAGATTTTATGTCCTTAGAAAAAGCTCTATGCCCTC
TATTCTGGTAGAAACAGGGTATTTAACTGGTAGAGATGATAATGGTAAACTGCAAAGTCCAGCTTACCAAAGACAAATGG
CAGATGCGATCGCTCGCGGTATTCTTCAGTACCTCAAACGATAG

Upstream 100 bases:

>100_bases
GAGCGTATCAAAACTCAAGATCAGGTGGCAAAGATGTGACAACTTGCCGATATGTTGAGACATTGACAGCTCTAATGAAT
GCAAATCAGGAGAATGGATT

Downstream 100 bases:

>100_bases
ATAATCAGTCAGTCTTCACAAACTTATAATCATCCTGATTGCCACACTATCCCTGTTATTCCTGAAGATTTTGTGTGAAT
ACTAACCACATCCTTATATT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MKLHWLLSGTVGTVLLLSSPALATRLNSWRFDANQNRLEINTTGAVQPRAQLIFNPTRLVIDLPNVTFGRSQLTQPIGGR
IRSVRVGQFDPQTTRIVVEVAPGYTLDPQQIKFVGLTANRWTVQLPTPTSEQAESSPDNTYNVVTIDSNTRPSLPNNTRP
ELPNNTRPEFSDNTISAAPGTTQIEGLQVTGDGFFVRTSGGNPQVQVIRSRDRATIFMDIAGATLSPRAPRNIPVNKHGV
NRVELTPLQTRTPSVRMTLRVDKNSPDWRATNSNAGGLVVLPSRVVRLPNNDNGEGNTSTLPDRITTTSAIATIQSVDLS
SNGTQLLIRADQAVSGNGGWDRNTGLFRITIPNAQLAPQVTGPSLSANSPILRIRLQKQEPNTVVVLVQPAAGVQVGQLN
KVGNQLLALQLQGSRRLATTPPLPPIQGQLPDPTNPRPLPQPGTRPVPKGRLSVFIDPGHGGKDPGAIGIGGVREKDIIL
PISQRIAQVLQQNGVQVVMARNSDFFVSLPGRVQMAERARADVFVSIHANAIGGNRADVNGLETYYYDSGLGLARAVHRS
ILQNVNVRDRGVRRARFYVLRKSSMPSILVETGYLTGRDDNGKLQSPAYQRQMADAIARGILQYLKR

Sequences:

>Translated_627_residues
MKLHWLLSGTVGTVLLLSSPALATRLNSWRFDANQNRLEINTTGAVQPRAQLIFNPTRLVIDLPNVTFGRSQLTQPIGGR
IRSVRVGQFDPQTTRIVVEVAPGYTLDPQQIKFVGLTANRWTVQLPTPTSEQAESSPDNTYNVVTIDSNTRPSLPNNTRP
ELPNNTRPEFSDNTISAAPGTTQIEGLQVTGDGFFVRTSGGNPQVQVIRSRDRATIFMDIAGATLSPRAPRNIPVNKHGV
NRVELTPLQTRTPSVRMTLRVDKNSPDWRATNSNAGGLVVLPSRVVRLPNNDNGEGNTSTLPDRITTTSAIATIQSVDLS
SNGTQLLIRADQAVSGNGGWDRNTGLFRITIPNAQLAPQVTGPSLSANSPILRIRLQKQEPNTVVVLVQPAAGVQVGQLN
KVGNQLLALQLQGSRRLATTPPLPPIQGQLPDPTNPRPLPQPGTRPVPKGRLSVFIDPGHGGKDPGAIGIGGVREKDIIL
PISQRIAQVLQQNGVQVVMARNSDFFVSLPGRVQMAERARADVFVSIHANAIGGNRADVNGLETYYYDSGLGLARAVHRS
ILQNVNVRDRGVRRARFYVLRKSSMPSILVETGYLTGRDDNGKLQSPAYQRQMADAIARGILQYLKR
>Mature_627_residues
MKLHWLLSGTVGTVLLLSSPALATRLNSWRFDANQNRLEINTTGAVQPRAQLIFNPTRLVIDLPNVTFGRSQLTQPIGGR
IRSVRVGQFDPQTTRIVVEVAPGYTLDPQQIKFVGLTANRWTVQLPTPTSEQAESSPDNTYNVVTIDSNTRPSLPNNTRP
ELPNNTRPEFSDNTISAAPGTTQIEGLQVTGDGFFVRTSGGNPQVQVIRSRDRATIFMDIAGATLSPRAPRNIPVNKHGV
NRVELTPLQTRTPSVRMTLRVDKNSPDWRATNSNAGGLVVLPSRVVRLPNNDNGEGNTSTLPDRITTTSAIATIQSVDLS
SNGTQLLIRADQAVSGNGGWDRNTGLFRITIPNAQLAPQVTGPSLSANSPILRIRLQKQEPNTVVVLVQPAAGVQVGQLN
KVGNQLLALQLQGSRRLATTPPLPPIQGQLPDPTNPRPLPQPGTRPVPKGRLSVFIDPGHGGKDPGAIGIGGVREKDIIL
PISQRIAQVLQQNGVQVVMARNSDFFVSLPGRVQMAERARADVFVSIHANAIGGNRADVNGLETYYYDSGLGLARAVHRS
ILQNVNVRDRGVRRARFYVLRKSSMPSILVETGYLTGRDDNGKLQSPAYQRQMADAIARGILQYLKR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI87082163, Length=237, Percent_Identity=29.957805907173, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1788776, Length=222, Percent_Identity=30.6306306306306, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790611, Length=239, Percent_Identity=30.1255230125523, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 68093; Mature: 68093

Theoretical pI: Translated: 11.57; Mature: 11.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHWLLSGTVGTVLLLSSPALATRLNSWRFDANQNRLEINTTGAVQPRAQLIFNPTRLV
CEEEEEECCCCEEEEEECCCHHHHHCCCEEECCCCCEEEEEECCCCCCCEEEEECCEEEE
IDLPNVTFGRSQLTQPIGGRIRSVRVGQFDPQTTRIVVEVAPGYTLDPQQIKFVGLTANR
EECCCCCCCHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCC
WTVQLPTPTSEQAESSPDNTYNVVTIDSNTRPSLPNNTRPELPNNTRPEFSDNTISAAPG
EEEECCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
TTQIEGLQVTGDGFFVRTSGGNPQVQVIRSRDRATIFMDIAGATLSPRAPRNIPVNKHGV
CCEEEEEEEECCEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
NRVELTPLQTRTPSVRMTLRVDKNSPDWRATNSNAGGLVVLPSRVVRLPNNDNGEGNTST
CEEEEEECCCCCCCEEEEEEECCCCCCCEECCCCCCCEEEECCEEEECCCCCCCCCCCCC
LPDRITTTSAIATIQSVDLSSNGTQLLIRADQAVSGNGGWDRNTGLFRITIPNAQLAPQV
CCCCCCCHHHHEEEEEEEECCCCCEEEEEECCEECCCCCCCCCCCEEEEEECCCCCCCCC
TGPSLSANSPILRIRLQKQEPNTVVVLVQPAAGVQVGQLNKVGNQLLALQLQGSRRLATT
CCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEECCHHHCCCEEEEEEECCCCEECCC
PPLPPIQGQLPDPTNPRPLPQPGTRPVPKGRLSVFIDPGHGGKDPGAIGIGGVREKDIIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCEEE
PISQRIAQVLQQNGVQVVMARNSDFFVSLPGRVQMAERARADVFVSIHANAIGGNRADVN
EHHHHHHHHHHHCCCEEEEEECCCEEEECCCCEEHHHCCCCEEEEEEEEEECCCCCCCCC
GLETYYYDSGLGLARAVHRSILQNVNVRDRGVRRARFYVLRKSSMPSILVETGYLTGRDD
CCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEEECEEECCCC
NGKLQSPAYQRQMADAIARGILQYLKR
CCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLHWLLSGTVGTVLLLSSPALATRLNSWRFDANQNRLEINTTGAVQPRAQLIFNPTRLV
CEEEEEECCCCEEEEEECCCHHHHHCCCEEECCCCCEEEEEECCCCCCCEEEEECCEEEE
IDLPNVTFGRSQLTQPIGGRIRSVRVGQFDPQTTRIVVEVAPGYTLDPQQIKFVGLTANR
EECCCCCCCHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCC
WTVQLPTPTSEQAESSPDNTYNVVTIDSNTRPSLPNNTRPELPNNTRPEFSDNTISAAPG
EEEECCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
TTQIEGLQVTGDGFFVRTSGGNPQVQVIRSRDRATIFMDIAGATLSPRAPRNIPVNKHGV
CCEEEEEEEECCEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
NRVELTPLQTRTPSVRMTLRVDKNSPDWRATNSNAGGLVVLPSRVVRLPNNDNGEGNTST
CEEEEEECCCCCCCEEEEEEECCCCCCCEECCCCCCCEEEECCEEEECCCCCCCCCCCCC
LPDRITTTSAIATIQSVDLSSNGTQLLIRADQAVSGNGGWDRNTGLFRITIPNAQLAPQV
CCCCCCCHHHHEEEEEEEECCCCCEEEEEECCEECCCCCCCCCCCEEEEEECCCCCCCCC
TGPSLSANSPILRIRLQKQEPNTVVVLVQPAAGVQVGQLNKVGNQLLALQLQGSRRLATT
CCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEECCHHHCCCEEEEEEECCCCEECCC
PPLPPIQGQLPDPTNPRPLPQPGTRPVPKGRLSVFIDPGHGGKDPGAIGIGGVREKDIIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCEEE
PISQRIAQVLQQNGVQVVMARNSDFFVSLPGRVQMAERARADVFVSIHANAIGGNRADVN
EHHHHHHHHHHHCCCEEEEEECCCEEEECCCCEEHHHCCCCEEEEEEEEEECCCCCCCCC
GLETYYYDSGLGLARAVHRSILQNVNVRDRGVRRARFYVLRKSSMPSILVETGYLTGRDD
CCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEEECEEECCCC
NGKLQSPAYQRQMADAIARGILQYLKR
CCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]