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The map label for this gene is menA [H]

Identifier: 17227529

GI number: 17227529

Start: 33548

End: 34477

Strand: Direct

Name: menA [H]

Synonym: alr0033

Alternate gene names: 17227529

Gene position: 33548-34477 (Clockwise)

Preceding gene: 17227527

Following gene: 17227530

Centisome position: 0.52

GC content: 41.61

Gene sequence:

>930_bases
ATGTTGAATTGCTTACCACAACTGATGACTACAAAGCAAATTTCTCATCCTAAAATTAAGCTATGGATGGCGGCAATTAA
ACCGCCAATGTATAGTGTTGCCATCATGCCCATTTGGGTGGGAGGAGCAGTTGCATTTGCTGGAAATAAAGTTTTTAATT
TAGCAGTATTTTTTACTTTTATAGTTGCTGCAATTTTAATTCTGGCTTGGGAAAATATCAGTAACGATGTATTTGATTCA
GAGACAGGAATTGATGTAAATAAGCATCATTCTCTGGTGAATTTAACTAAAAAGAAGACTCTGGTATTTTGGTTAGGAAA
TTTGTGTCTAATTTCCGGTTTATTGGGGATATTAGCAATCGCCACTTGGCAACAAGACCCCACAGTTATCGGCATCATCT
TGTTATGCTGCGGTTTGGGCTATATGTACCAAGGGCCTCCCTTTCGTTTAGGATATCAAGGCTTAGGTGAGATTCTGTGC
TTCTTTGCCTTTGGCCCCTTAGGCGTGTCAGCAGGATACTATAGCCAAACTCAAACTTGGTCAATCACAAGTTTAGCCGC
TTCAGTCATTGTCGGGATTGTCACAAGTTTAGTTTTATTTTGCTCTCACTTTCACCAAGTTGATGATGACATTAAAGCCG
GTAAGCGATCGCCCATCGTCCGTTTAGGTACAGCCAACGGTGCAAAAGTTCTCACTTGGTTTACAGCCAGCATTTACCCC
TTCAGCTTGCTGTTTGTACTCTTGGGATTCTTCCCTGTGTGGACGCTGTTAAGTTGGCTAAGTTTACCTTACGCCTTCAA
GCTATGTCGCCACGTCCAGCACAACCACAACCAACCAGAAAAAGTCAGCAATTGTAAATTCATCGCCGTAGCCGTTCATT
TCTGGAGTTGCTTATTACTAGGTTTGGGATTTGTCATTGCAGGGGTTTAA

Upstream 100 bases:

>100_bases
GGGTATAAGGTTGTGGAGGTATAAGGGATACTTCCTAAAAAAAATAGTAGCTTTATTTAACCTGCGCTCTACTAGCTAGA
GGTATTGTTTGTAATTTTCA

Downstream 100 bases:

>100_bases
TACTTATTGTGTTTCCCAATTATGAATTCAGCTTTCGCCCCATAGCCCGAAAATTTGTGCGATCGCTCGTTACTAGTCAT
GGTATCTGGGAAGTGCGCGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLNCLPQLMTTKQISHPKIKLWMAAIKPPMYSVAIMPIWVGGAVAFAGNKVFNLAVFFTFIVAAILILAWENISNDVFDS
ETGIDVNKHHSLVNLTKKKTLVFWLGNLCLISGLLGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILC
FFAFGPLGVSAGYYSQTQTWSITSLAASVIVGIVTSLVLFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYP
FSLLFVLLGFFPVWTLLSWLSLPYAFKLCRHVQHNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV

Sequences:

>Translated_309_residues
MLNCLPQLMTTKQISHPKIKLWMAAIKPPMYSVAIMPIWVGGAVAFAGNKVFNLAVFFTFIVAAILILAWENISNDVFDS
ETGIDVNKHHSLVNLTKKKTLVFWLGNLCLISGLLGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILC
FFAFGPLGVSAGYYSQTQTWSITSLAASVIVGIVTSLVLFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYP
FSLLFVLLGFFPVWTLLSWLSLPYAFKLCRHVQHNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV
>Mature_309_residues
MLNCLPQLMTTKQISHPKIKLWMAAIKPPMYSVAIMPIWVGGAVAFAGNKVFNLAVFFTFIVAAILILAWENISNDVFDS
ETGIDVNKHHSLVNLTKKKTLVFWLGNLCLISGLLGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILC
FFAFGPLGVSAGYYSQTQTWSITSLAASVIVGIVTSLVLFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYP
FSLLFVLLGFFPVWTLLSWLSLPYAFKLCRHVQHNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=286, Percent_Identity=25.8741258741259, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737429, Length=305, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34018; Mature: 34018

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNCLPQLMTTKQISHPKIKLWMAAIKPPMYSVAIMPIWVGGAVAFAGNKVFNLAVFFTF
CCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCHHHHHHHHHHH
IVAAILILAWENISNDVFDSETGIDVNKHHSLVNLTKKKTLVFWLGNLCLISGLLGILAI
HHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLGVSAGYYSQTQTW
HHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SITSLAASVIVGIVTSLVLFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCEEEEHHHHHHHH
FSLLFVLLGFFPVWTLLSWLSLPYAFKLCRHVQHNHNQPEKVSNCKFIAVAVHFWSCLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHH
GLGFVIAGV
HHHHHHHCC
>Mature Secondary Structure
MLNCLPQLMTTKQISHPKIKLWMAAIKPPMYSVAIMPIWVGGAVAFAGNKVFNLAVFFTF
CCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCHHHHHHHHHHH
IVAAILILAWENISNDVFDSETGIDVNKHHSLVNLTKKKTLVFWLGNLCLISGLLGILAI
HHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLGVSAGYYSQTQTW
HHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SITSLAASVIVGIVTSLVLFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCEEEEHHHHHHHH
FSLLFVLLGFFPVWTLLSWLSLPYAFKLCRHVQHNHNQPEKVSNCKFIAVAVHFWSCLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHH
GLGFVIAGV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]