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The map label for this gene is aceK [H]

Identifier: 16767435

GI number: 16767435

Start: 4405078

End: 4406829

Strand: Direct

Name: aceK [H]

Synonym: STM4185

Alternate gene names: 16767435

Gene position: 4405078-4406829 (Clockwise)

Preceding gene: 16767434

Following gene: 39546391

Centisome position: 90.69

GC content: 52.68

Gene sequence:

>1752_bases
ATGCCGCGTGGCCTGGAATTACTGATTGCTCAAACCATCCTGCAAGGCTTTGACGCGCAGTATGGTCGATTTCTGGAAGT
GACTTCCGGCGCGCAGCAGCGTTTTGAACAGGCCGACTGGCACGCCGTCCAACAGGCGATGAAAAGCCGTATCCACCTCT
ATGATCATCATGTGGGTCTGGTGGTGGAGCAACTGCGCTGTATTACCGATGGCAAAAGTACCGACGCGGATTTCCTTTTA
CGCGTTAAAGAGCATTACACCCGGCTGTTGCCGGATTACCCGCGCTTCGAGATTGCGGAGAGCTTTTTCAACTCCGTTTA
TTGCCGGTTATTTGACCACCGCTCGTTAACACCCGAGCGGTTGTTTATTTTCAGTTCGCAACCGGAGCGCCGCTTCCGTA
CTATCCCGCGCCCGCTGGCCAAAGACTTCTTTCCCGATCACGGTTGGGAGCCGCTGTTGATGCGCATACTCAGTGACTTA
CCGCTGCGTCTGCCCTGGCAGAATAAAAGCCGGGATATCCGCTATATTATCGCGCACCTGACTGAAACACTGGGCGAGGA
CGCGCTACCTCGCTGCCATGTCCAGGTGGCGAACGAGTTGTTTTACCGTAATAAAGCGGCCTGGCTGGTAGGTAAATTAA
CCACACCTGACGGTACGCTGCCGTTTTTATTGCCGATTCATCGCACTGATGAGGGGGAACTGTTTGTCGATACCTGCCTG
ACCACCACGGCAGAAGCGAGCATTGTGTTTGGTTTTGCCCGCTCTTATTTTATGGTGTATGCGCCGCTGCCTGCCGCGCT
GGTTGAGTGGTTGCGTGAAATCCTGCCGGGTAAAACCACTGCCGAACTGTATATGGCGATTGGCTGCCAGAAACATGCGA
AAACCGAAAGCTACCGCGAATATTTATGTTATCTGGCTGAAAGCGATGAGAAATTTATTGAGGCGCCTGGCATCCGCGGC
ATGGTGATGCTGGTGTTTACCCTGCCAGGTTTCGACCGGGTATTTAAAATCATTAAAGACAAATTCGCCCCGCAGAAAGA
GATGTCTGCCGCCCATGTGCGTGCCTGTTATCAACTGGTAAAAGAGCATGATCGCGTCGGTCGTATGGCGGATACCCAGG
AGTTTGAGAATTTCGTGCTGGATAAACGGCAAATTGATCCGGCGCTGATGGCGCTGTTACGACAAGAAGCGCCAGAGAAG
ATTACCGATCTTGGGGAACATATCGTCATTCGCCATCTCTATATTGAACGTCGCATGGTGCCGCTCAATATCTGGCTGGA
ACAGGTAGAAGGCCAGCAGTTGCGCGATGCGATAGAAGAATATGGTAATGCGATTCGCCAGCTTGCCGCCGCTAATATTT
TCCCCGGCGATATGTTGTTTAAAAACTTTGGCGTTACCCGTCATGGTCGCGTGGTGTTCTACGACTACGATGAAATTTGC
TACATGACGGAAGTGAATTTCCGCGATATTCCGCCAGCGCGTTATCCGGAAGACGAACTGGCCAGCGAACCCTGGTATAG
CGTCTCGCCAGGTGATGTTTTCCCGGAGGAGTTTCGCCACTGGCTGTGTGCCGATCCGCGTATCGGGCCATTGTTTGAAG
AGATGCATGCCGACCTGTTTCGCGCCGATTACTGGCGCGCGCTACAGACGCGTATTAAAGAAGGGCATGTAGAAGATGTG
TATGCCTATCGACGTAGACAGCGCTTTAGCGTGCGTTACGGCGCGATCTCAAGTACGGCGAACTCTTCGTAA

Upstream 100 bases:

>100_bases
TGATGCCCGGTGGCGCTGCGCTTACCGGGCCTACAGATAGCGTAGGCCGGATAAGCGAACGCGCCATCCGGCATGACGTG
GTGCCGGATGAGGGAAAAAA

Downstream 100 bases:

>100_bases
ACCAGTTCCATCTCCGGCGACCAATTACCCTCGCGCTCAAAAAAGGCCCGGTGTGCCGCTTGCCAGTACGCCAGGCTAAG
ATCGCCTTCGCCTTCCAGTG

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCITDGKSTDADFLL
RVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDL
PLRLPWQNKSRDIRYIIAHLTETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCL
TTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLCYLAESDEKFIEAPGIRG
MVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEK
ITDLGEHIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQTRIKEGHVEDV
YAYRRRQRFSVRYGAISSTANSS

Sequences:

>Translated_583_residues
MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCITDGKSTDADFLL
RVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDL
PLRLPWQNKSRDIRYIIAHLTETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCL
TTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLCYLAESDEKFIEAPGIRG
MVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEK
ITDLGEHIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQTRIKEGHVEDV
YAYRRRQRFSVRYGAISSTANSS
>Mature_582_residues
PRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCITDGKSTDADFLLR
VKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDLP
LRLPWQNKSRDIRYIIAHLTETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCLT
TTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLCYLAESDEKFIEAPGIRGM
VMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEKI
TDLGEHIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICY
MTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQTRIKEGHVEDVY
AYRRRQRFSVRYGAISSTANSS

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=576, Percent_Identity=92.7083333333333, Blast_Score=1113, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 67957; Mature: 67825

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGL
CCCCHHHHHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLRCITDGKSTDADFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPER
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDLPLRLPWQNKSRDIRYIIAHL
EEEECCCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
TETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCL
HHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEHHHH
TTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYRE
HHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHH
YLCYLAESDEKFIEAPGIRGMVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLV
HHHHHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEKITDLGEHIVIRHLYIERRMV
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
PLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLF
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RADYWRALQTRIKEGHVEDVYAYRRRQRFSVRYGAISSTANSS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCCCC
>Mature Secondary Structure 
PRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGL
CCCHHHHHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLRCITDGKSTDADFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPER
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDLPLRLPWQNKSRDIRYIIAHL
EEEECCCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
TETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCL
HHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEHHHH
TTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYRE
HHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHH
YLCYLAESDEKFIEAPGIRGMVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLV
HHHHHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEKITDLGEHIVIRHLYIERRMV
HHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
PLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLF
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RADYWRALQTRIKEGHVEDVYAYRRRQRFSVRYGAISSTANSS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]