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The map label for this gene is yihU

Identifier: 16767288

GI number: 16767288

Start: 4233764

End: 4234660

Strand: Reverse

Name: yihU

Synonym: STM4023

Alternate gene names: 16767288

Gene position: 4234660-4233764 (Counterclockwise)

Preceding gene: 39546386

Following gene: 16767287

Centisome position: 87.18

GC content: 56.08

Gene sequence:

>897_bases
ATGGCAGTTATAGCATTTATCGGGTTGGGACAGATGGGCTCCCCTATGGCGAGCAATCTGCTAAAGCAGGGCCATCAACT
CAGCGTCTTCGATGTTAATCCCGACGCCGTACAGCGTCTGGTAGACAAAGGCGCGCAACCTGCAAGCAGCCCGGCTCAGG
CAACCATCGGCGCTGAATTTGTTATCACCATGCTCCCGAACGGCGATCTGGTTCGTTCCGTTTTGTTTGGCGAGCAAGGC
GTTTGTGAAACTCTTTCCCGTGAAGCGCTGGTCATTGATATGTCCACTATTCATCCGTTGCAAACCGATAATCTGATTGC
CGACATGCAGAGCAAAGGGTTCAGCATGATGGATGTGCCGATAGGCCGGACATCCGACAACGCGATTACCGGCACATTGT
TGCTGCTGGCAGGCGGTACGGCGGAGCAAGTAGAGCGTGCTACCCCTGTTCTGATGGCGATGGGTAATGAGCTGGTCAAC
ACCGGCGGCCCGGGAATGGGTATTCGCGTAAAACTGATCAACAACTACATGAGTATTGCGCTAAATGCGCTCTCCGCCGA
AGCCGCCGTGCTGTGTGAAGCGCTGGGGCTTTCCTTCGACGTGGCTTTAAAAGTGATGAGCGGCACTGCCGCAGGCAAAG
GGCATTTCACCACCACCTGGCCGAATAAAGTGATGAAAGGAGATCTGTCTCCCGCCTTCATGATCGATCTGGCGCACAAA
GATCTTGGCATCGCGTTGGATGTCGCCAATCAACTGCACGTACCGATGCCGCTCGGCGCCGCCTCCCGTGAAGTTTATAA
CCTGGCGCGGGCCGCAGGCCGCGGTCGGGAAGACTGGAGCGCCATCCTGGAACAGGTGCGCATCAGCGCCGGGCTGACCG
CCAACGTAAAAAAGTAA

Upstream 100 bases:

>100_bases
CTGTCAATTTTTTGACTATAAATTACAAATACGATCACAAACAGACAGAAAAATGCTCATTAATGACAAAAAATGACACC
ACCGTGTTCAGGAGAACGAT

Downstream 100 bases:

>100_bases
CGACTGTATAAAGGAAAATTGAATGAACAACTACACCATCAAAGACATTACGCGAGCGTCCGGCGGGTTTGCCATGCTGG
CTGTCGATCAGCGCGAGGCG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVPIGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Sequences:

>Translated_298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVPIGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
>Mature_297_residues
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEFVITMLPNGDLVRSVLFGEQGV
CETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVPIGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNT
GGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHKD
LGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=33.1058020477816, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=25.2631578947368, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=86.8686868686869, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=36.7857142857143, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=30.7958477508651, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=30.7167235494881, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=28.9036544850498, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=32.1917808219178, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=32.1917808219178, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=24.2214532871972, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YIHU_SALTY (Q9L7S0)

Other databases:

- EMBL:   AF220438
- EMBL:   AE006468
- RefSeq:   NP_462903.1
- ProteinModelPortal:   Q9L7S0
- SMR:   Q9L7S0
- GeneID:   1255549
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM4023
- NMPDR:   fig|99287.1.peg.3875
- HOGENOM:   HBG729179
- OMA:   CETLSHE
- ProtClustDB:   PRK15461
- BioCyc:   STYP99287:STM4023-MONOMER
- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR22981

Pfam domain/function: PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: 1.1.-.- [C]

Molecular weight: Translated: 31281; Mature: 31150

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: ACT_SITE 171-171 BINDING 96-96 BINDING 240-240

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEF
CEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHCCCEEEECC
IGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEF
EEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHCCCEEEECC
IGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609