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The map label for this gene is ggt [H]

Identifier: 16766837

GI number: 16766837

Start: 3720462

End: 3722204

Strand: Reverse

Name: ggt [H]

Synonym: STM3551

Alternate gene names: 16766837

Gene position: 3722204-3720462 (Counterclockwise)

Preceding gene: 16766839

Following gene: 16766831

Centisome position: 76.63

GC content: 55.25

Gene sequence:

>1743_bases
ATGAAACCAACGTTTATGCGCTGGGTGGCGATCGCCGCTCTGCTGGCCGGGGGGACGTTTAGCGCGGTGGCCAATCCTCC
CGTCGCGCCGCCAGTCTCCTATGGTGTTGAAGAAGATGTCTTTCATCCTGTGCGGGCGACGCAAGGGATGGTGGCCTCGG
TGGATGCAATGGCGACGCAGGTTGGCGTGGATATCTTAAAGCAGGGCGGTAATGCCGTGGATGCCGCCGTCGCCGTGGGC
TATGCGCTGGCTGTCACGCATCCGCAAGCCGGAAATCTGGGCGGCGGGGGATTTATGCTGCTGCGCACTAAAGATGGCGC
TACCACGGCGATCGATTTTCGTGAAATGGCGCCTGCTGGCGCGACCCGTGATATGTTCCTCGACGATCAGGGTAACGCCG
ATGCGAAAAAGTCGCTGACGTCGCATCTGGCATCCGGTACGCCGGGTACCGTGGCGGGGTTCTCGCTGGCGCTGGAGAAA
TACGGCACGATGCCGCTGAATAAAGTGGTGCGTCCGGCGATGAAGCTGGCGGAAGAGGGTTTTGTGGTTAACGATGCGCT
GGCCAACGACTTAAAAACTTACGGCAGCGAAGTGATCCTCAACCATGAGAACAGCAAAGCCATTTTCTGGAAAGACGGCG
AGCCGCTGAAAAAAGGCGATAAGCTGGTCCAGAAGAATCTGGCGAAAAGCCTGGAAATGATTGCCGAAAACGGCCCGGAT
GCGTTTTATAAAGGGGCGATTGCTGACCAAATAGCCGGAGAAATGCAGAAGAACGGCGGTCTGATGACCAAAGAGGATTT
AGCCAACTATAAAGCCGTTGAGCGTACGCCAATCAGCGGTGACTATCGCGGGTATCAGGTCTTCTCCATGCCGCCGCCAT
CCTCGGGCGGTATTCACATCGTACAGATCCTTAATATTCTTGAAAATTTCGACATGAAGAAGTACGGCTTTGGCAGCGCC
GATGCCATGCAAATCATGGCGGAAGCGGAAAAATACGCCTACGCTGACCGCTCAGAGTATCTGGGCGATCCGGACTTTGT
GAAAGTGCCGTGGCAGGCGCTGACCCACAAAGCCTATGCGAAAACGCTGGCCGATCAAATTGATATCAACAAGGCCAAAC
CTTCCAGCCAGATAAAACCGGGCAAGCTCGCCCCGTATGAAAGCAACCAGACCACCCACTTCTCGGTGGTGGATAAAGAC
GGCAATGCTGTGGCGGTGACCTATACCCTGAACACCACCTTCGGCACAGGAATTGTGGCGGGAAATACCGGTATTCTGCT
GAATAATCAAATGGATGATTTTTCTGCTAAACCCGGTGTACCTAATGTTTATGGCCTGGTGGGCGGCGATGCTAACGCGG
TCGGTCCGAAGAAGCGTCCGCTGTCGTCGATGTCGCCCACTATCGTCGTTAAAGAGGGCAAAACCTGGCTGGTGACCGGC
AGCCCTGGCGGGAGTCGAATCATCACTACTGTGCTGCAAATGGTAGTGAATAGCATTGATTTTGGCATGAACGTCGCCGA
AGCGACCAACGCGCCGCGTTTCCATCATCAATGGTTGCCGGACGAACTGCGGGTAGAAAAGGGCTTCAGCCCCGATACGC
TAAAGTTGCTGGAACAGAAAGGGCAGAAAGTGGCGCTGAAAGAAGCGATGGGCAGCACCCAAAGTATTATGGTTGGACCG
GATGGTGAACTGTATGGCGCTTCCGACCCGCGTTCGGTGGATGATTTAACGGCGGGATACTGA

Upstream 100 bases:

>100_bases
TTTTTAAGTGTACCTCTATTTCGCCATGATGATGATTTTTTAAGCGTTGTGGGCCAGGATTAAACGGGACATACACCCAT
TTATCTGGAGAAAAACAACG

Downstream 100 bases:

>100_bases
TTTTTAATTCCAGGCCCGGTGTCAGACACCGGGCTATTTGCAGATTATGCCGTGAGTAATCGGGCTGGATTATCAATACA
AAGCTTGCGCAGAGTATCGT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALANDLKTYGSEVILNHENSKAIFWKDGEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMQKNGGLMTKEDLANYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKEGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Sequences:

>Translated_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALANDLKTYGSEVILNHENSKAIFWKDGEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMQKNGGLMTKEDLANYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKEGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY
>Mature_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAGATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALANDLKTYGSEVILNHENSKAIFWKDGEPLKKGDKLVQKNLAKSLEMIAENGPD
AFYKGAIADQIAGEMQKNGGLMTKEDLANYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKEGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=534, Percent_Identity=32.5842696629214, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI73915090, Length=534, Percent_Identity=32.5842696629214, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI73915096, Length=534, Percent_Identity=32.5842696629214, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI73915094, Length=534, Percent_Identity=32.5842696629214, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=31.2734082397004, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI113429326, Length=538, Percent_Identity=30.6691449814126, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=32.2404371584699, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=29.2196007259528, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=28.804347826087, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=27.2232304900181, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=34.2465753424658, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=34.2465753424658, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI218505805, Length=218, Percent_Identity=33.0275229357798, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI310124095, Length=218, Percent_Identity=31.1926605504587, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=90.8620689655172, Blast_Score=1071, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=575, Percent_Identity=34.4347826086956, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI212646519, Length=575, Percent_Identity=34.4347826086956, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17542894, Length=529, Percent_Identity=34.2155009451796, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI193208245, Length=555, Percent_Identity=32.4324324324324, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193208247, Length=556, Percent_Identity=32.1942446043165, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17506189, Length=558, Percent_Identity=30.8243727598566, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17564448, Length=442, Percent_Identity=28.0542986425339, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI72001497, Length=221, Percent_Identity=26.6968325791855, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=221, Percent_Identity=26.6968325791855, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=496, Percent_Identity=30.6451612903226, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45551474, Length=543, Percent_Identity=32.4125230202578, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24642670, Length=543, Percent_Identity=32.4125230202578, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642666, Length=543, Percent_Identity=32.4125230202578, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077880, Length=543, Percent_Identity=32.4125230202578, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077878, Length=543, Percent_Identity=32.4125230202578, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=30.5343511450382, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.8880308880309, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI18859741, Length=558, Percent_Identity=28.494623655914, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61721; Mature: 61721

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHCCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAG
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEHHHHCCCC
ATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALANDLKTYGSEVILNHENSKAIFWKDGEPLKKGDKLVQKNLAKSLEMIAENGPD
CEEEHHHHHHHHHCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMQKNGGLMTKEDLANYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKEGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHCCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAG
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEHHHHCCCC
ATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
CCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALANDLKTYGSEVILNHENSKAIFWKDGEPLKKGDKLVQKNLAKSLEMIAENGPD
CEEEHHHHHHHHHCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMQKNGGLMTKEDLANYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTHKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPKKRPLSSMSPTIVVKEGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]