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The map label for this gene is pabA

Identifier: 16766757

GI number: 16766757

Start: 3619759

End: 3620322

Strand: Reverse

Name: pabA

Synonym: STM3469

Alternate gene names: 16766757

Gene position: 3620322-3619759 (Counterclockwise)

Preceding gene: 16766758

Following gene: 16766756

Centisome position: 74.53

GC content: 55.14

Gene sequence:

>564_bases
ATGATCCTGCTTATCGATAACTATGATTCCTTTACCTGGAACCTCTACCAGTATTTTTGTGAACTGGGCGCGGAAGTGCA
GGTCCGGCGCAATGATGCGCTAACGCTGGCGCACATTGACGCTTTGAACCCGCAAAAAATCGTTATCTCTCCTGGCCCCT
GTACGCCGAATGACGCTGGCATTTCACTGGCGGTCATCCGCCATTATGCCGGACGTATTCCGATGCTGGGCGTTTGCCTG
GGTCATCAGGCGATGGCGCAGGCCTTTGGTGCGTCGGTAGTGCGGGCAGCGAAAGTGATGCACGGTAAAACGTCACCTGT
TACGCATAATGGACAGGGCGTGTTTCGGGGATTGCCCAGCCCGTTAACCGTGACACGTTACCACTCGCTGATTGTCGACC
CTGCCACGTTGCCTGAGTGTTTTGAGATCACCGCCTGGAGCGAAACGCAGGAGATTATGGGCATTCGCCACCGCGAGTGG
GATCTGGAAGGCGTGCAGTTCCACCCGGAAAGTATTCTCAGCGAACAAGGACACGCTCTGCTGAAAAATTTCCTCCGGCG
TTGA

Upstream 100 bases:

>100_bases
ATGGGCGATCTCTCCGCTTTGCGGGCGATTTTTCAGAAAGCGATAAGCGAAGCTCGCGAAACTGAGTAAAATAGTGCGGT
TCTACTCACCCGGAGCCGCC

Downstream 100 bases:

>100_bases
TTTGTGGTTGCTATTGAGTGATTTTTTATTCATATTTTGTGATTATAATTTCACTGGCATTTCTACTTAACCGGGTGGTA
ATGATATGGCAACTGAACAA

Product: para-aminobenzoate synthase component II

Products: NA

Alternate protein names: ADC synthase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MILLIDNYDSFTWNLYQYFCELGAEVQVRRNDALTLAHIDALNPQKIVISPGPCTPNDAGISLAVIRHYAGRIPMLGVCL
GHQAMAQAFGASVVRAAKVMHGKTSPVTHNGQGVFRGLPSPLTVTRYHSLIVDPATLPECFEITAWSETQEIMGIRHREW
DLEGVQFHPESILSEQGHALLKNFLRR

Sequences:

>Translated_187_residues
MILLIDNYDSFTWNLYQYFCELGAEVQVRRNDALTLAHIDALNPQKIVISPGPCTPNDAGISLAVIRHYAGRIPMLGVCL
GHQAMAQAFGASVVRAAKVMHGKTSPVTHNGQGVFRGLPSPLTVTRYHSLIVDPATLPECFEITAWSETQEIMGIRHREW
DLEGVQFHPESILSEQGHALLKNFLRR
>Mature_187_residues
MILLIDNYDSFTWNLYQYFCELGAEVQVRRNDALTLAHIDALNPQKIVISPGPCTPNDAGISLAVIRHYAGRIPMLGVCL
GHQAMAQAFGASVVRAAKVMHGKTSPVTHNGQGVFRGLPSPLTVTRYHSLIVDPATLPECFEITAWSETQEIMGIRHREW
DLEGVQFHPESILSEQGHALLKNFLRR

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=85.0267379679144, Blast_Score=345, Evalue=1e-96,
Organism=Escherichia coli, GI1787517, Length=188, Percent_Identity=40.9574468085106, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788854, Length=191, Percent_Identity=28.7958115183246, Blast_Score=67, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322638, Length=185, Percent_Identity=51.8918918918919, Blast_Score=225, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324361, Length=212, Percent_Identity=29.2452830188679, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PABA_SALTY (P06193)

Other databases:

- EMBL:   X02603
- EMBL:   M32355
- EMBL:   AE006468
- PIR:   S09636
- RefSeq:   NP_462372.1
- ProteinModelPortal:   P06193
- SMR:   P06193
- PRIDE:   P06193
- GeneID:   1254992
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM3469
- NMPDR:   fig|99287.1.peg.3349
- HOGENOM:   HBG292341
- OMA:   NSENIIM
- ProtClustDB:   PRK08007
- BioCyc:   STYP99287:STM3469-MONOMER
- BRENDA:   2.6.1.85
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =2.6.1.85

Molecular weight: Translated: 20801; Mature: 20801

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I ; PS00678 WD_REPEATS_1

Important sites: ACT_SITE 79-79 ACT_SITE 168-168 ACT_SITE 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLIDNYDSFTWNLYQYFCELGAEVQVRRNDALTLAHIDALNPQKIVISPGPCTPNDAG
CEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCC
ISLAVIRHYAGRIPMLGVCLGHQAMAQAFGASVVRAAKVMHGKTSPVTHNGQGVFRGLPS
CHHHHHHHHHCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
PLTVTRYHSLIVDPATLPECFEITAWSETQEIMGIRHREWDLEGVQFHPESILSEQGHAL
CEEEEEHHHEEECCCCCCHHEEEECCCCHHHHHCCCCCCCCCCCEEECHHHHHHHCCHHH
LKNFLRR
HHHHHCC
>Mature Secondary Structure
MILLIDNYDSFTWNLYQYFCELGAEVQVRRNDALTLAHIDALNPQKIVISPGPCTPNDAG
CEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCC
ISLAVIRHYAGRIPMLGVCLGHQAMAQAFGASVVRAAKVMHGKTSPVTHNGQGVFRGLPS
CHHHHHHHHHCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
PLTVTRYHSLIVDPATLPECFEITAWSETQEIMGIRHREWDLEGVQFHPESILSEQGHAL
CEEEEEHHHEEECCCCCCHHEEEECCCCHHHHHCCCCCCCCCCCEEECHHHHHHHCCHHH
LKNFLRR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3894673; 2403545; 11677609