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The map label for this gene is yjmC [H]

Identifier: 16766382

GI number: 16766382

Start: 3242326

End: 3243333

Strand: Reverse

Name: yjmC [H]

Synonym: STM3081

Alternate gene names: 16766382

Gene position: 3243333-3242326 (Counterclockwise)

Preceding gene: 16766383

Following gene: 16766381

Centisome position: 66.77

GC content: 51.09

Gene sequence:

>1008_bases
ATGTCAACAATATTAGTCAAAGAAAATGAATTGAAAGCGCTGGCGTTTAATAAACTCACCCAGGCGGGTCTTGACGCGCA
AACGGCGCAGCAGGTAGCCGACGTTTTGGTTCATGCCGATATTACCGGCGTTCACTCCCACGGCGTTATTCGCGTAGAGC
ACTATTGTACCCGCCTGAACGCAGGCGGGCTCAATCCAAAAGCAACATTCAGCATCGAACAGATTTCGCCTTCAGTCGCT
ATTCTGGACTCTGATGATGGAATGGGACACTGCGCGCTGATAAAGGCGACAGATCACGCTATTAGTCTGGCGAGAGAGAC
GGGGCTGGGTTTCGTCAGCGTCAAAAATACGTCCCACTGCGGCGCGCTCTCGTGGTTCATTGAGCAGGCGACAAGCCAGG
GAATGGTGGCTATCGCCATGACGCGAACGGATACCTGTGTTGCGCCGTATGGCGGCGCGGAGCGCTTTCTGGGGACTAAC
CCAATCGCCTTCGGCTTCCCCGTTAAAGACAGCCATCCGATGATCGTCGATATGGCGACCAGCGCCATTGCGTTTGGTAA
AATTCTGCACGCCAAAGAAACCGGGAAACCAATAGGTCATGGTCTGGCGCTGGATAAAGAGGGACATATCACTACCGATC
CGCATAAAATTGAAAATCTGCTGCCCTTTGGCGGACACAAAGGTTCTGGTATTGCCCTGGCGATTGATGCGCTCACGGGC
GTCCTGATGGGGGCAAACTTTAGCAACCATATTGTTCGGATGTATGGCGACTATGACAAGATGCGCAAGTTAGCGAGTCT
GGTTATCGTTATTGATCCGCAGATGTTGGGCAATCCGCTGTTTTCCTCAATAATGAGCACAATGGTCAATGAGCTAAGGG
CTGTAAAACCGATGCCCGGTGTTGATAAAGTGCTGGCGCCAAACGATCCGCAAATCGCCTATAAAGAAAAATGTTTAAAA
GAAGGTATTCCTGTGGCTGAAGGTATTTACCAGTACCTGATTGGCTGA

Upstream 100 bases:

>100_bases
GAATTCGATTTCTATACGTTCGGCAACCAGTACCAGAAGAACGTGGTAGAAAACAAAAAATTGGTTAAAGGCGTTATCAA
ATTTTAATAGCGGGATAGTT

Downstream 100 bases:

>100_bases
TAATTATAATCACGACCATTATTTAGGATAACTATAGTATGCTATATGGAAATATAGAGCAGCTTACTTTATTACCTTAC
GTTAACCACATTATTAAAAA

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSTILVKENELKALAFNKLTQAGLDAQTAQQVADVLVHADITGVHSHGVIRVEHYCTRLNAGGLNPKATFSIEQISPSVA
ILDSDDGMGHCALIKATDHAISLARETGLGFVSVKNTSHCGALSWFIEQATSQGMVAIAMTRTDTCVAPYGGAERFLGTN
PIAFGFPVKDSHPMIVDMATSAIAFGKILHAKETGKPIGHGLALDKEGHITTDPHKIENLLPFGGHKGSGIALAIDALTG
VLMGANFSNHIVRMYGDYDKMRKLASLVIVIDPQMLGNPLFSSIMSTMVNELRAVKPMPGVDKVLAPNDPQIAYKEKCLK
EGIPVAEGIYQYLIG

Sequences:

>Translated_335_residues
MSTILVKENELKALAFNKLTQAGLDAQTAQQVADVLVHADITGVHSHGVIRVEHYCTRLNAGGLNPKATFSIEQISPSVA
ILDSDDGMGHCALIKATDHAISLARETGLGFVSVKNTSHCGALSWFIEQATSQGMVAIAMTRTDTCVAPYGGAERFLGTN
PIAFGFPVKDSHPMIVDMATSAIAFGKILHAKETGKPIGHGLALDKEGHITTDPHKIENLLPFGGHKGSGIALAIDALTG
VLMGANFSNHIVRMYGDYDKMRKLASLVIVIDPQMLGNPLFSSIMSTMVNELRAVKPMPGVDKVLAPNDPQIAYKEKCLK
EGIPVAEGIYQYLIG
>Mature_334_residues
STILVKENELKALAFNKLTQAGLDAQTAQQVADVLVHADITGVHSHGVIRVEHYCTRLNAGGLNPKATFSIEQISPSVAI
LDSDDGMGHCALIKATDHAISLARETGLGFVSVKNTSHCGALSWFIEQATSQGMVAIAMTRTDTCVAPYGGAERFLGTNP
IAFGFPVKDSHPMIVDMATSAIAFGKILHAKETGKPIGHGLALDKEGHITTDPHKIENLLPFGGHKGSGIALAIDALTGV
LMGANFSNHIVRMYGDYDKMRKLASLVIVIDPQMLGNPLFSSIMSTMVNELRAVKPMPGVDKVLAPNDPQIAYKEKCLKE
GIPVAEGIYQYLIG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=330, Percent_Identity=40.6060606060606, Blast_Score=257, Evalue=7e-70,
Organism=Escherichia coli, GI1787020, Length=322, Percent_Identity=29.1925465838509, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790000, Length=241, Percent_Identity=31.1203319502075, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17507179, Length=325, Percent_Identity=28.6153846153846, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17536633, Length=300, Percent_Identity=27.6666666666667, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45553211, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24667912, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24667904, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24667908, Length=326, Percent_Identity=33.1288343558282, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24648360, Length=305, Percent_Identity=28.5245901639344, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24658010, Length=310, Percent_Identity=26.4516129032258, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 35724; Mature: 35593

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTILVKENELKALAFNKLTQAGLDAQTAQQVADVLVHADITGVHSHGVIRVEHYCTRLN
CCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEEEEHHHHHCC
AGGLNPKATFSIEQISPSVAILDSDDGMGHCALIKATDHAISLARETGLGFVSVKNTSHC
CCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCCC
GALSWFIEQATSQGMVAIAMTRTDTCVAPYGGAERFLGTNPIAFGFPVKDSHPMIVDMAT
HHHHHHHHHHCCCCEEEEEEECCCCEECCCCCHHHHCCCCCEEEECCCCCCCCEEEEHHH
SAIAFGKILHAKETGKPIGHGLALDKEGHITTDPHKIENLLPFGGHKGSGIALAIDALTG
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHCCCCCCCCCCCEEEEHHHHHH
VLMGANFSNHIVRMYGDYDKMRKLASLVIVIDPQMLGNPLFSSIMSTMVNELRAVKPMPG
HHHCCCCCCCEEEEECCHHHHHHHHEEEEEECHHHHCCHHHHHHHHHHHHHHHHCCCCCC
VDKVLAPNDPQIAYKEKCLKEGIPVAEGIYQYLIG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STILVKENELKALAFNKLTQAGLDAQTAQQVADVLVHADITGVHSHGVIRVEHYCTRLN
CEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEEEEHHHHHCC
AGGLNPKATFSIEQISPSVAILDSDDGMGHCALIKATDHAISLARETGLGFVSVKNTSHC
CCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCCC
GALSWFIEQATSQGMVAIAMTRTDTCVAPYGGAERFLGTNPIAFGFPVKDSHPMIVDMAT
HHHHHHHHHHCCCCEEEEEEECCCCEECCCCCHHHHCCCCCEEEECCCCCCCCEEEEHHH
SAIAFGKILHAKETGKPIGHGLALDKEGHITTDPHKIENLLPFGGHKGSGIALAIDALTG
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHCCCCCCCCCCCEEEEHHHHHH
VLMGANFSNHIVRMYGDYDKMRKLASLVIVIDPQMLGNPLFSSIMSTMVNELRAVKPMPG
HHHCCCCCCCEEEEECCHHHHHHHHEEEEEECHHHHCCHHHHHHHHHHHHHHHHCCCCCC
VDKVLAPNDPQIAYKEKCLKEGIPVAEGIYQYLIG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]