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The map label for this gene is sipB

Identifier: 16766191

GI number: 16766191

Start: 3029114

End: 3030895

Strand: Reverse

Name: sipB

Synonym: STM2885

Alternate gene names: 16766191

Gene position: 3030895-3029114 (Counterclockwise)

Preceding gene: 16766192

Following gene: 16766190

Centisome position: 62.4

GC content: 52.3

Gene sequence:

>1782_bases
ATGGTAAATGACGCAAGTAGCATTAGCCGTAGCGGATATACCCAAAATCCGCGCCTCGCTGAGGCGGCTTTTGAAGGCGT
TCGTAAGAACACGGACTTTTTAAAAGCGGCGGATAAAGCTTTTAAAGATGTGGTGGCAACGAAAGCGGGCGACCTTAAAG
CCGGAACAAAGTCCGGCGAGAGCGCTATTAATACGGTGGGTCTAAAGCCGCCTACGGACGCCGCCCGGGAAAAACTCTCC
AGCGAAGGGCAATTGACATTACTGCTTGGCAAGTTAATGACCCTACTGGGCGATGTTTCGCTGTCTCAACTGGAGTCTCG
TCTGGCGGTATGGCAGGCGATGATTGAGTCACAAAAAGAGATGGGGATTCAGGTATCGAAAGAATTCCAGACGGCTCTGG
GAGAGGCTCAGGAGGCGACGGATCTCTATGAAGCCAGTATCAAAAAGACGGATACCGCCAAGAGTGTTTATGACGCTGCG
ACCAAAAAACTGACGCAGGCGCAAAATAAATTGCAATCGCTGGACCCGGCTGACCCCGGCTATGCACAAGCTGAAGCCGC
GGTAGAACAGGCCGGAAAAGAAGCGACAGAGGCGAAAGAGGCCTTAGATAAGGCCACGGATGCGACGGTTAAAGCAGGCA
CAGACGCCAAAGCGAAAGCCGAGAAAGCGGATAACATTCTGACCAAATTCCAGGGAACGGCTAATGCCGCCTCTCAGAAT
CAGGTTTCCCAGGGTGAGCAGGATAATCTGTCAAATGTCGCCCGCCTCACTATGCTCATGGCCATGTTTATTGAGATTGT
GGGCAAAAATACGGAAGAAAGCCTGCAAAACGATCTTGCGCTTTTCAACGCCTTGCAGGAAGGGCGTCAGGCGGAGATGG
AAAAGAAATCGGCTGAATTCCAGGAAGAGACGCGCAAAGCCGAGGAAACGAACCGCATTATGGGATGTATCGGGAAAGTC
CTCGGCGCGCTGCTAACCATTGTCAGCGTTGTGGCCGCTGTTTTTACCGGTGGGGCGAGTCTGGCGCTGGCTGCGGTGGG
ACTTGCGGTAATGGTGGCCGATGAAATTGTGAAGGCGGCGACGGGAGTGTCGTTTATTCAGCAGGCGCTAAACCCGATTA
TGGAGCATGTGCTGAAGCCGTTAATGGAGCTGATTGGCAAGGCGATTACCAAAGCGCTGGAAGGATTAGGCGTCGATAAG
AAAACGGCAGAGATGGCCGGCAGCATTGTTGGTGCGATTGTCGCCGCTATTGCCATGGTGGCGGTCATTGTGGTGGTCGC
AGTTGTCGGGAAAGGCGCGGCGGCGAAACTGGGTAACGCGCTGAGCAAAATGATGGGCGAAACGATTAAGAAGTTGGTGC
CTAACGTGCTGAAACAGTTGGCGCAAAACGGCAGCAAACTCTTTACCCAGGGGATGCAACGTATTACTAGCGGTCTGGGT
AATGTGGGTAGCAAGATGGGCCTGCAAACGAATGCCTTAAGTAAAGAGCTGGTAGGTAATACCCTAAATAAAGTGGCGTT
GGGCATGGAAGTCACGAATACCGCAGCCCAGTCAGCCGGTGGTGTTGCCGAGGGCGTATTTATTAAAAATGCCAGCGAGG
CGCTTGCTGATTTTATGCTCGCCCGTTTTGCCATGGATCAGATTCAGCAGTGGCTTAAACAATCCGTAGAAATATTTGGT
GAAAACCAGAAGGTAACGGCGGAACTGCAAAAAGCCATGTCTTCTGCGGTACAGCAAAATGCGGATGCTTCGCGTTTTAT
TCTGCGCCAGAGTCGCGCATAA

Upstream 100 bases:

>100_bases
GTACTGAAGATGAGTCTCTGCGGGCAAAAGCGTTGGTCTATCTGGAGGCGCTAAAAACGGCGGAGACAGAGCAGCACAGT
GAACAAGAAAAGGAATAATT

Downstream 100 bases:

>100_bases
AAACTGCCAAAATAAAGGGAGAAAAATATGTTAATTAGTAATGTGGGAATAAATCCCGCCGCTTATTTAAATAATCATTC
TGTTGAGAATAGTTCACAGA

Product: translocation machinery component

Products: NA

Alternate protein names: Effector protein sipB

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLS
SEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAA
TKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQN
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKV
LGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDK
KTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFG
ENQKVTAELQKAMSSAVQQNADASRFILRQSRA

Sequences:

>Translated_593_residues
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLS
SEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAA
TKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQN
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKV
LGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDK
KTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFG
ENQKVTAELQKAMSSAVQQNADASRFILRQSRA
>Mature_593_residues
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLS
SEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAA
TKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQN
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKV
LGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDK
KTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFG
ENQKVTAELQKAMSSAVQQNADASRFILRQSRA

Specific function: Required for entry into the host cell through presentation or delivery of sipC at the host cell plasma membrane. Along with sipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (By similarity). Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) and inserted into the host cell plasma membrane (By similarity)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the invasin protein B family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SIPB_SALDU (Q79BT1)

Other databases:

- EMBL:   U66877
- PRIDE:   Q79BT1
- GO:   GO:0009405
- InterPro:   IPR006972
- InterPro:   IPR003895
- PRINTS:   PR01375

Pfam domain/function: PF04888 SseC

EC number: NA

Molecular weight: Translated: 62451; Mature: 62451

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf80ce10)-; HASH(0xf69e640)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGE
CCCCHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SAINTVGLKPPTDAAREKLSSEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKE
HHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAATKKLTQAQNKLQSLDPADPG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQN
HHHHHHHHHHHCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEF
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEETRKAEETNRIMGCIGKVLGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDKKTAEMAGSIVGAIVAAIAMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFML
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
ARFAMDQIQQWLKQSVEIFGENQKVTAELQKAMSSAVQQNADASRFILRQSRA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH
>Mature Secondary Structure
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGE
CCCCHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SAINTVGLKPPTDAAREKLSSEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKE
HHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAATKKLTQAQNKLQSLDPADPG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQN
HHHHHHHHHHHCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEF
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEETRKAEETNRIMGCIGKVLGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDKKTAEMAGSIVGAIVAAIAMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFML
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
ARFAMDQIQQWLKQSVEIFGENQKVTAELQKAMSSAVQQNADASRFILRQSRA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA