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The map label for this gene is sicA

Identifier: 16766192

GI number: 16766192

Start: 3030898

End: 3031395

Strand: Reverse

Name: sicA

Synonym: STM2886

Alternate gene names: 16766192

Gene position: 3031395-3030898 (Counterclockwise)

Preceding gene: 16766193

Following gene: 16766191

Centisome position: 62.41

GC content: 42.57

Gene sequence:

>498_bases
ATGGATTATCAAAATAATGTCAGCGAAGAACGTGTTGCGGAAATGATTTGGGATGCCGTTAGTGAAGGCGCCACGCTAAA
AGACGTTCATGGGATCCCTCAAGATATGATGGACGGTTTATATGCTCATGCTTATGAGTTTTATAACCAGGGACGACTGG
ATGAAGCTGAGACGTTCTTTCGTTTCTTATGCATTTATGATTTTTACAATCCCGATTACACCATGGGACTGGCGGCAGTA
TGCCAACTGAAAAAACAATTTCAGAAAGCATGTGACCTTTATGCAGTAGCGTTTACGTTACTTAAAAATGATTATCGCCC
CGTTTTTTTTACCGGGCAGTGTCAATTATTAATGCGTAAGGCAGCAAAAGCCAGACAGTGTTTTGAACTTGTCAATGAAC
GTACTGAAGATGAGTCTCTGCGGGCAAAAGCGTTGGTCTATCTGGAGGCGCTAAAAACGGCGGAGACAGAGCAGCACAGT
GAACAAGAAAAGGAATAA

Upstream 100 bases:

>100_bases
TTTTGAATGTTCACTAACCACCGTCGGGGTTTAATAACTGCATCAGATAAACGCAGTCGTTAAGTTCTACAAAGTCGGTG
ACAGATAACAGGAGTAAGTA

Downstream 100 bases:

>100_bases
TTATGGTAAATGACGCAAGTAGCATTAGCCGTAGCGGATATACCCAAAATCCGCGCCTCGCTGAGGCGGCTTTTGAAGGC
GTTCGTAAGAACACGGACTT

Product: secretion chaperone

Products: NA

Alternate protein names: Salmonella invasin chaperone

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAV
CQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHS
EQEKE

Sequences:

>Translated_165_residues
MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAV
CQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHS
EQEKE
>Mature_165_residues
MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAV
CQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHS
EQEKE

Specific function: Type III secretion-associated chaperone required for sipB and sipC stabilization. Prevents premature association of sipB with sipC, which may lead to their targeting for degradation. Along with invF, required for transcription activation of sigDE (sopB pi

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lcrH/sycD chaperone family

Homologues:

Organism=Escherichia coli, GI1789215, Length=146, Percent_Identity=35.6164383561644, Blast_Score=112, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SICA_SALDU (P69064)

Other databases:

- EMBL:   U66877
- ProteinModelPortal:   P69064
- SMR:   P69064
- PRIDE:   P69064
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0009405
- GO:   GO:0006350
- InterPro:   IPR005415
- InterPro:   IPR016379
- InterPro:   IPR011716
- InterPro:   IPR011990
- Gene3D:   G3DSA:1.25.40.10
- PIRSF:   PIRSF003165
- PRINTS:   PR01595
- TIGRFAMs:   TIGR02552

Pfam domain/function: PF07720 TPR_3

EC number: NA

Molecular weight: Translated: 19221; Mature: 19221

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFF
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RFLCIYDFYNPDYTMGLAAVCQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
AAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHSEQEKE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFF
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RFLCIYDFYNPDYTMGLAAVCQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
AAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHSEQEKE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA