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The map label for this gene is sipC [H]

Identifier: 16766190

GI number: 16766190

Start: 3027857

End: 3029086

Strand: Reverse

Name: sipC [H]

Synonym: STM2884

Alternate gene names: 16766190

Gene position: 3029086-3027857 (Counterclockwise)

Preceding gene: 16766191

Following gene: 16766189

Centisome position: 62.36

GC content: 47.72

Gene sequence:

>1230_bases
ATGTTAATTAGTAATGTGGGAATAAATCCCGCCGCTTATTTAAATAATCATTCTGTTGAGAATAGTTCACAGACAGCTTC
GCAATCCGTTAGCGCTAAAGATATTCTGAATAGTATTGGTATTAGCAGCAGTAAAGTCAGTGACCTGGGGTTGAGTCCTA
CACTGAGCGCGCCTGCGCCAGGGGTATTAACGCAAACCCCCGGAACGATCACGTCCTTTTTAAAAGCCAGTATTCAAAAT
ACCGACATGAATCAGGATTTGAATGCTCTGGCAAATAATGTCACGACTAAAGCGAATGAGGTTGTGCAAACCCAGTTACG
CGAGCAGCAGGCAGAAGTCGGAAAGTTTTTTGATATTAGCGGAATGTCTTCCAGTGCCGTTGCGCTGTTGGCTGCCGCGA
ATACGTTAATGCTGACGTTGAACCAGGCTGATAGCAAACTGTCTGGTAAGTTGTCATTAGTCAGTTTTGATGCAGCTAAA
ACGACGGCAAGCTCCATGATGCGCGAAGGGATGAATGCGTTGTCCGGTAGTATTTCCCAGAGCGCGCTTCAGTTGGGGAT
CACTGGCGTGGGCGCCAAACTGGAATATAAGGGGCTGCAGAATGAAAGAGGCGCGCTTAAACATAATGCCGCGAAGATCG
ATAAACTGACCACTGAAAGCCACAGTATTAAAAACGTGCTGAACGGGCAGAATAGCGTCAAACTCGGTGCTGAAGGCGTC
GATTCTCTGAAATCGTTAAATATGAAGAAAACCGGTACCGATGCGACGAAAAATCTTAATGATGCGACGCTTAAATCTAA
TGCCGGAACCAGCGCCACGGAAAGTCTGGGTATTAAAGACAGTAATAAACAAATCTCCCCTGAACATCAGGCTATTCTGT
CGAAACGTCTTGAGTCTGTCGAATCCGATATTCGTCTTGAGCAGAATACCATGGATATGACCCGAATCGATGCGCGCAAG
ATGCAGATGACGGGCGATCTGATTATGAAGAACTCGGTCACGGTCGGTGGTATTGCAGGGGCGTCCGGGCAGTACGCCGC
TACTCAGGAACGTTCCGAGCAGCAAATTAGCCAGGTGAATAACCGGGTTGCCAGCACCGCATCGGACGAAGCCCGTGAAA
GTTCACGTAAATCGACCAGCCTGATTCAGGAAATGCTGAAAACAATGGAGAGCATTAACCAGTCGAAAGCATCCGCACTC
GCTGCTATCGCAGGCAATATTCGCGCTTAA

Upstream 100 bases:

>100_bases
AAAAGCCATGTCTTCTGCGGTACAGCAAAATGCGGATGCTTCGCGTTTTATTCTGCGCCAGAGTCGCGCATAAAAACTGC
CAAAATAAAGGGAGAAAAAT

Downstream 100 bases:

>100_bases
TCTGAAAGGTCATCTATACGCCATCATGGGTGTGATTTAATCGCGCTCCTGATGGCGAACTGGGGATATTATGCTTAATA
TTCAAAATTATTCCGCTTCT

Product: translocation machinery component

Products: NA

Alternate protein names: Effector protein sipC [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA

Sequences:

>Translated_409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA
>Mature_409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA

Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates sipC activity and both are required for an efficient bacterial internalization

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the invasin protein C family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005427 [H]

Pfam domain/function: PF09599 IpaC_SipC [H]

EC number: NA

Molecular weight: Translated: 42984; Mature: 42984

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAP
CEECCCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCC
GVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDIS
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQ
CCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCHHHH
SALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECHHHH
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESV
HHHHHCCCCCCCCCHHCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVN
HHHHEECCCHHHHHHHHHHHHHHHCCEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
NRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAP
CEECCCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCC
GVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDIS
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQ
CCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCHHHH
SALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECHHHH
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESV
HHHHHCCCCCCCCCHHCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVN
HHHHEECCCHHHHHHHHHHHHHHHCCEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
NRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8801431; 11677608; 12644504 [H]