| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is sipA [H]
Identifier: 16766188
GI number: 16766188
Start: 3024679
End: 3026736
Strand: Reverse
Name: sipA [H]
Synonym: STM2882
Alternate gene names: 16766188
Gene position: 3026736-3024679 (Counterclockwise)
Preceding gene: 16766189
Following gene: 16766187
Centisome position: 62.31
GC content: 48.01
Gene sequence:
>2058_bases ATGGTTACAAGTGTAAGGACTCAGCCCCCCGTCATAATGCCAGGTATGCAGACCGAGATCAAAACGCAGGCCACGAATCT TGCGGCGAATCTTTCCGCAGTCAGAGAAAGTGCCACAGCGACGCTGTCAGGGGAAATTAAAGGCCCGCAACTGGAAGATT TTCCCGCGCTGATCAAACAGGCGAGTCTGGATGCATTGTTTAAATGCGGGAAAGACGCTGAGGCGTTAAAAGAAGTTTTT ACCAATTCAAATAATGTCGCCGGTAAGAAAGCGATAATGGAGTTTGCCGGGCTCTTTCGTTCAGCGCTCAACGCCACCAG TGATTCTCCTGAGGCGAAGACGCTACTGATGAAGGTGGGGGCAGAGTATACCGCGCAAATCATAAAAGATGGCCTGAAAG AAAAGTCAGCTTTTGGGCCATGGCTGCCAGAAACAAAGAAAGCGGAAGCGAAGCTGGAAAACCTGGAAAAGCAGCTGTTA GATATTATCAAAAATAACACTGGCGGTGAATTAAGTAAATTATCGACGAATCTTGTTATGCAGGAGGTGATGCCCTATAT TGCCAGCTGCATTGAACATAACTTTGGCTGTACGTTAGATCCGTTAACCCGCAGCAATCTTACGCACCTTGTTGACAAAG CGGCGGCGAAGGCTGTTGAGGCGCTTGATATGTGCCACCAAAAATTAACGCAAGAGCAGGGTACCAGCGTAGGACGGGAA GCCCGGCACCTTGAAATGCAAACGTTGATACCCCTGCTGCTACGTAATGTTTTTGCACAAATTCCTGCAGATAAACTGCC TGACCCTAAAATTCCGGAGCCTGCGGCTGGACCAGTACCTGATGGTGGGAAAAAAGCAGAACCTACGGGTATTAATATCA ATATTAATATTGATAGCAGTAACCATAGCGTGGATAACAGTAAGCATATTAACAATAGCCGAAGCCATGTCGATAATAGC CAGCGCCATATCGATAATAGCAACCATGATAATAGCCGGAAGACGATTGATAATAGCCGAACATTTATTGATAACAGCCA ACGCAATGGCGAGTCACACCATTCGACTAACAGCAGCAACGTAAGTCATAGTCATTCGCGTGTGGATTCGACTACGCATC AAACGGAGACGGCACACAGCGCCAGCACAGGGGCAATTGACCATGGCATCGCGGGTAAAATTGACGTCACGGCTCATGCG ACGGCAGAGGCTGTGACCAACGCTTCATCCGAAAGTAAAGATGGAAAGGTGGTCACGTCAGAAAAGGGCACTACGGGTGA AACAACCTCTTTTGATGAAGTCGATGGCGTAACCAGCAAGAGCATTATCGGCAAGCCGGTACAGGCCACGGTGCACGGCG TTGATGATAATAAACAGCAAAGCCAGACGGCAGAGATTGTGAATGTGAAGCCGCTTGCCAGTCAACTGGCTGGCGTCGAG AATGTTAAAACCGATACCTTACAATCAGACACGACGGTAATTACAGGTAATAAAGCCGGTACGACCGATAATGATAATAG TCAGACAGATAAGACTGGCCCATTTTCTGGTTTGAAGTTTAAGCAAAATAGTTTCCTCTCAACAGTACCGAGCGTTACGA ATATGCATTCAATGCATTTCGACGCCCGTGAGACGTTTTTGGGTGTGATACGTAAAGCCCTGGAGCCAGATACCTCCACA CCGTTCCCTGTACGCAGAGCGTTTGACGGCTTGCGTGCGGAAATATTACCCAATGACACGATAAAGAGTGCAGCGTTGAA AGCGCAATGTAGCGATATTGACAAGCACCCAGAATTGAAAGCGAAAATGGAGACTCTCAAAGAGGTCATTACTCATCATC CACAAAAAGAAAAACTGGCTGAGATTGCACTGCAGTTTGCCAGAGAGGCGGGGCTGACCAGGCTAAAAGGGGAAACTGAC TATGTGTTAAGTAATGTGCTGGACGGCCTTATCGGAGACGGTAGCTGGCGAGCTGGCCCGGCTTACGAGTCATACCTGAA TAAACCTGGCGTGGATCGGGTTATTACTACCGTTGATGGCTTGCACATGCAGCGTTAA
Upstream 100 bases:
>100_bases ATTGTACGACAACCTGGTAAAAGTGCTGAGCAGTACGATAAGTAGCAGCCTGGAAACCGCCAAAAGCTTCCTGCAAGGAT AACAGAAGAGGATATTAATA
Downstream 100 bases:
>100_bases TTAACCGGGAAAGATGCGATGAATATGGATATTGAAGCAAGAGTCAAAAAAGTGATCACCTCTTGTATTGCCGTTGATGT TGATAGTATCAATGGTCAGA
Product: secreted effector protein
Products: NA
Alternate protein names: Effector protein sipA [H]
Number of amino acids: Translated: 685; Mature: 685
Protein sequence:
>685_residues MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVF TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS QRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHA TAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE NVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTST PFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETD YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
Sequences:
>Translated_685_residues MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVF TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS QRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHA TAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE NVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTST PFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETD YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR >Mature_685_residues MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVF TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS QRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHA TAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE NVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTST PFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETD YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates sipC activity; both are required for an efficient bacterial internalization [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) (By similarity) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the sipA/ipaA family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015138 - InterPro: IPR023224 - InterPro: IPR023225 [H]
Pfam domain/function: PF09052 SipA [H]
EC number: NA
Molecular weight: Translated: 73943; Mature: 73943
Theoretical pI: Translated: 6.58; Mature: 6.58
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQ CCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHH ASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVG HHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH AEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVM HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH QEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE HHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSS HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC NHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSN CCCCCCCHHCCCCHHHCCCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCC VSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHATAEAVTNASSESKDGKVVTS CCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEC EKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE CCCCCCCCCCCHHHCCCCHHHHCCCCHHHEEECCCCCHHHHHHHHHHCCHHHHHHHCCCC NVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHF CCCHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHHHHHHCC DARETFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELK HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH AKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETDYVLSNVLDGLIGDGSWRAGP HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCC AYESYLNKPGVDRVITTVDGLHMQR HHHHHCCCCCHHHHHHHHCCHHCCC >Mature Secondary Structure MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQ CCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHH ASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVG HHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH AEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVM HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH QEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE HHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSS HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC NHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSN CCCCCCCHHCCCCHHHCCCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCC VSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHATAEAVTNASSESKDGKVVTS CCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEC EKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE CCCCCCCCCCCHHHCCCCHHHHCCCCHHHEEECCCCCHHHHHHHHHHCCHHHHHHHCCCC NVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHF CCCHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHHHHHHCC DARETFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELK HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH AKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETDYVLSNVLDGLIGDGSWRAGP HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCC AYESYLNKPGVDRVITTVDGLHMQR HHHHHCCCCCHHHHHHHHCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA