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The map label for this gene is tktB [H]

Identifier: 16765794

GI number: 16765794

Start: 2583500

End: 2585500

Strand: Direct

Name: tktB [H]

Synonym: STM2474

Alternate gene names: 16765794

Gene position: 2583500-2585500 (Clockwise)

Preceding gene: 16765793

Following gene: 16765798

Centisome position: 53.19

GC content: 55.97

Gene sequence:

>2001_bases
ATGTCCCGTAAAGACCTTGCCAATGCGATTCGTGCGCTGAGCATGGATGCCGTTCAAAAAGCCAATTCCGGGCACCCCGG
CGCGCCGATGGGGATGGCGGATATCGCTGAAGTGCTATGGAACGATTTTCTTAAACATAACCCCACCGATCCGACCTGGT
ATGACCGTGATCGTTTTATCCTTTCCAACGGTCACGCCTCCATGCTGCTCTATAGTCTGCTGCATTTAACCGGGTATGAC
CTGCCGCTGGAGGAGTTAAAAAACTTCCGTCAACTGCACTCTAAAACGCCAGGTCACCCGGAGATTGGCTATACGCCCGG
CGTTGAAACCACCACCGGACCGCTGGGCCAGGGGCTGGCGAATGCCGTCGGGCTGGCGATTGCCGAGCGTACGTTAGGCG
CACAGTTCAACCGGCCGGACCATGAGATTGTCGACCACTACACCTATGTCTTTATGGGCGACGGCTGTCTGATGGAGGGG
ATCTCGCATGAGGTGTGTTCGCTGGCTGGTACGCTGGGACTGGGCAAACTGATCGGCTTTTACGATCACAACGGCATCTC
CATTGATGGCGAAACCGAAGGCTGGTTTACCGACGATACCGCCAAACGTTTTGAAGCCTACCACTGGCATGTCGTACATG
ACATTGACGGGCACGATCCGGAGGCGGTGAAAAAAGCCATTCTCGAAGCCCAGAGCGTAAAAGATAAACCTTCGCTAATT
ATCTGTCGGACGGTGATAGGTTTTGGCTCGCCGAATAAAGCCGGGAAGGAGGAGTCGCACGGCGCGGCGCTGGGCGAAGA
AGAGGTGGCGCTGACCCGCCAGAAGCTGGGATGGCATCATCCGGCGTTTGAGATCCCAAAAGAAATTTACCGCGCGTGGG
ATGGCCGTGAAAAAGGCGAGAAAGCGCAGCAGCAGTGGCAGGAAAAGTTTGCTGCTTATGAGAAGGCTTATCCTGAGCTG
GCCGCGGAGTTTACCCGCCGGATGAGCGGCGGACTGCCGGAGGCATGGGAATCCGCCACGCAAAAATTTATTAACGACTT
GCAGGCTAATCCGGCCAAAATCGCCACCCGTAAAGCATCGCAAAATACGCTCAATGCCTACGGTCCCCTGTTGCCGGAAC
TGTTGGGCGGATCGGCAGATCTGGCGCCGAGCAACCTGACTATCTGGAAAGGTTCGACCTCGTTGAAAGAGGATCCGGCA
GGTAATTATATCCACTATGGCGTGCGCGAATTCGGCATGACCGCCATTGCTAACGGCATCGCCCACCACGGCGGCTTTGT
ACCGTATACCGCCACGTTTCTGATGTTTGTCGAATATGCGCGTAACGCGGCGCGTATGGCGGCCTTAATGAAAGCCCGGC
AGATTATGGTCTATACCCACGACTCCATCGGTTTGGGCGAAGATGGCCCGACGCACCAGGCCGTGGAACAACTGGCGAGC
CTGCGCTTAACGCCTAACTTCAGCACCTGGCGTCCCTGCGATCAGGTTGAGGCGGCAGTCGGCTGGAAGCTGGCCATTGA
ACGTCAGCACGGGCCGACGGCGCTGATTCTCTCGCGGCAGAATCTGGCGCAGGTGGAACGCACGCCGGAACAGGTGAAAG
CGATTGCCCGCGGCGGTTATATTCTGAAAGATAGCGGCGGCAAGCCGGATATCATTCTGATCGCTACCGGATCGGAAATG
GAAATTACCCTACAGGCGGCGGAAAAATTGACTGGCGAGGGGCATAACGTTCGCGTGGTGTCGTTGCCTTCAACGGATAT
TTTCGATGCGCAGGACGAGGCATATCGCGAATCAGTGCTACCGGCACACGTAACCGCCCGCGTCGCGGTGGAGGCCGGTA
TAGCCGACTACTGGTATAAATATGTTGGCCTAAAAGGCGCAATTATCGGCATGACGGGATACGGTGAATCCGCTCCGGCT
GACAAACTGTTCCCGTATTTTGGCTTTACCGTGGAAAATATTGTAGAAAAAGCCCGCCGGGTGCTAAACATCAAAGGCTA
A

Upstream 100 bases:

>100_bases
GTAGAGAAGCTGTCGGAAGGTATCCGTCTTTTTGCCGTTGACCAGCGCAAACTGGAAGACCTGCTTGCCGCCAAACTATA
AACCTTGCATGGAGTGATTT

Downstream 100 bases:

>100_bases
GGCGAGCGTTAGCAACACAGACTTTGCACAGTCTGCAGACCTGTTCTGTAGGCTGTGCAAAATTACTTCGTAGACTCAGG
CGCATCTGACTGCCCGATGA

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG

Sequences:

>Translated_666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG
>Mature_665_residues
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYDL
PLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGI
SHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLII
CRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPELA
AEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAG
NYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLASL
RLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEME
ITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPAD
KLFPYFGFTVENIVEKARRVLNIKG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=29.3609671848014, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=29.3609671848014, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI133778974, Length=678, Percent_Identity=26.8436578171091, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI225637459, Length=676, Percent_Identity=22.4852071005917, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI225637463, Length=483, Percent_Identity=24.4306418219462, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637461, Length=646, Percent_Identity=22.1362229102167, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=92.9429429429429, Blast_Score=1300, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=75.9455370650529, Blast_Score=1082, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=666, Percent_Identity=25.0750750750751, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=47.8978978978979, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=45.440956651719, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=592, Percent_Identity=28.0405405405405, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45550715, Length=592, Percent_Identity=28.0405405405405, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24666278, Length=587, Percent_Identity=25.8943781942078, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=27.7173913043478, Blast_Score=146, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73060; Mature: 72929

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYEKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC
>Mature Secondary Structure 
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYEKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]