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The map label for this gene is cbh [H]

Identifier: 16764885

GI number: 16764885

Start: 1615333

End: 1616424

Strand: Direct

Name: cbh [H]

Synonym: STM1540

Alternate gene names: 16764885

Gene position: 1615333-1616424 (Clockwise)

Preceding gene: 16764875

Following gene: 16764886

Centisome position: 33.25

GC content: 47.71

Gene sequence:

>1092_bases
ATGATGAAAAAAAGTAAAGCAATGTTATTTATCGCTCCGGCGCTGTTTTCATACGCCCTGGCGGCACAGGCCTGCACGAC
CCTTGCTATTCAGGATAAACAAGGCGATATTTTTCATGGGCGTACGCTGGAATATATGCAGGATTTACCCTCATGGTTAA
CGTATTACCCGGCGGGAACACAGTTTGATAAAAAAACGCCGGATGGCAGCCAGGGGATAAGCTATCAGGCGAAGTATCCG
ATACTGGCCATTACTTCCACCATTACTGATGGCGATAGCAGAGACATACTTGAAGGCATGAATAGCGCGGGATTGTCATT
TAGTGAAAACATGATCATGAATGCGCAGTTGCCGCCATTGCCCGCGAGTGAATATAAACAGGCAATTCCTGTCACCTCGT
TGGGAGAATGGGCGCTGGCCCGTTTTGCTACTGTCGGCGAGGTAAAACAGGCAATAAAAGAGGGCAAATTCTGGTCACCA
GAACTGCATCGGTTTGGCGATCTGAAATCGCCATTTCATTACGCGTTTTACGACAAGAAAGGAGGAAGCATTGTCGTTGA
AGTGGAAAATGGTAAATTCCATGTCTATGACAATCCCACTCGCGTGATGACAAATGGTCCCGCATTCCCCTGGCATCTGA
CAAATCTGAATAATTATACGCAATTAACCAATGTGGACCGCTCTTCAGGCACACTGGGCGGGATAAAAGTGATGCAGCCT
GATAGCGGGATTGCTATTGCAGACTTGCCATCGTCCGATACGTCGGTTTCCCGTTTTATACGCGGCGTTTATTACACCAC
ATATGCGCCGCAAGCGACATCCGCCCACGATGCAATGAATACGCTTGCGCATATTATGAGCCGTTTCGATCGTCCGAAAA
ATATTACGGTTGATTATATGGGGAGTGAAGGGGAAGGCAACGCCACCCGCAAACCGGTCTCAGAATATACGGTCTGGACA
ACGCTGTCTGACTTAATGCACGGTGAGATGATGGTGCGCGGCTACAATGATATCAACTATAAAACCTGGTCTCTTTCTCA
GTTTAAGAACGCGACAGCGCCCGTGTTCGAGAAAATCAACGTCAAAGGATAA

Upstream 100 bases:

>100_bases
TTAGCTTGTAAAATAAGATCACAATTAATTACGTGCTGCATAACCATTGATAGGTTTAATTTAATATATTCATCCAATCC
ATTTTACAAACAAGGAGAGC

Downstream 100 bases:

>100_bases
ATAGCTCATCTCGGTTTAGTTTCCCCGGTAGTCTCGGCGAAGGTAATGGAGACTACCGGCGGTTGCTTCTCTTTATCATG
CACGGTAATTAATTATCACG

Product: hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MMKKSKAMLFIAPALFSYALAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLMHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG

Sequences:

>Translated_363_residues
MMKKSKAMLFIAPALFSYALAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLMHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG
>Mature_363_residues
MMKKSKAMLFIAPALFSYALAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLMHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 40282; Mature: 40282

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKSKAMLFIAPALFSYALAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGT
CCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCEECCCHHHHHHHHHHHHEECCCCC
QFDKKTPDGSQGISYQAKYPILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPL
CCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCC
PASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSPELHRFGDLKSPFHYAFYDKK
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
GGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
CCEEEEEEECCEEEEECCCCEEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCEEEECC
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYM
CCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
GSEGEGNATRKPVSEYTVWTTLSDLMHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKIN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEHHHHCCCCCCHHHHCC
VKG
CCC
>Mature Secondary Structure
MMKKSKAMLFIAPALFSYALAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGT
CCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCEECCCHHHHHHHHHHHHEECCCCC
QFDKKTPDGSQGISYQAKYPILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPL
CCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCC
PASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSPELHRFGDLKSPFHYAFYDKK
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
GGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
CCEEEEEEECCEEEEECCCCEEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCEEEECC
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYM
CCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
GSEGEGNATRKPVSEYTVWTTLSDLMHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKIN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEHHHHCCCCCCHHHHCC
VKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]