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The map label for this gene is ompC [H]

Identifier: 16764875

GI number: 16764875

Start: 1606415

End: 1607533

Strand: Direct

Name: ompC [H]

Synonym: STM1530

Alternate gene names: 16764875

Gene position: 1606415-1607533 (Clockwise)

Preceding gene: 16764872

Following gene: 16764885

Centisome position: 33.07

GC content: 46.38

Gene sequence:

>1119_bases
ATGAAAAAAGTAGTGGTGTTATCTGCGGTAGCCGCAGCCGTAATGATGGCTGGAGCCGCCAACGCAGCAGAAATCTATAA
CAAGGATGGCAATAAACTGGATTTGTATGGCAAGGTCGACGGCCTGCATTATTTTTCCAGTAATCATAGTACGGATGGCG
ATCAATCTTATATCCGTATGGGTATTAAAGGCGAGACTCAAATTACCGATCAACTAACCGGTTTTGGACAGTGGGAGTAT
CAGGTCAACGCCAATCGTCCGGAAGATGGTGACTCCAGCGGTTCCCCGCAAAGCTGGACGCGTCTCGGTTTTGCTGGTTT
GGCATTTGCCGATATGGGGTCTGTTGATTATGGTCGTAACTATGGCGTGTTATACGACATTGGTTCATGGACTGACGTAC
TGCCTGAATTTGGTAATGATTCGTATGAAGCTTCCGATAATTTTATGACCGGACGCGCGAATGGCGTTCTGACTTATCGC
AATAATGATTTCTTTGGTCTGGTTGATGGTCTGAATATTGCGTTGCAGTATCAGGGTAAAAATGACGGCCTGTCGAAAGA
AGGCGATCCTTTAAGTAATAATGCCAGAAAAAGTATCGCGTACCAGAATGGCGATGGTTTCGGGGCATCAGCGACATATG
ATTTGGGCATGGGGGTGAGCCTGGGGGCAGCCTATACCAGTTCCAAACGCACGCTTGATCAGATGACGCAAGATAAATAC
GACAATGGCGACCGCGCTGAAGCCTGGACTGGCGGCGTGAAGTATGATGCCAATAATATTTACCTGGCGGCAAACTATAC
CCGTACTTATGATATGACCTATATGGGCGATACATTGGGCGGCTTTGCACATAAAACCGATAACTGGGAAATGGTAGGGC
AATATCAATTTGATAATGGCTTACGCCCGTCACTGGCGTTCCTGCAATCCAGAGCCAATGATGTTGATGGACTGGGTTCG
TTCGACCTTGTGAAATATATTGATGTGGGTTCCTACTACTACTTCAATAAAAATATGTCCGCGTATGTTGACTACAAAAT
CAATCTGCTAAAAGATGGCAACCCATCGAATCCTAATACAGACAACACCGTGGCGCTCGGCTTAGTCTACGAGTTTTGA

Upstream 100 bases:

>100_bases
TGAAACTTAACGCACGGTAATTGTTAGTGATATTGTCCTGGACAGTTCCGCGAGCAGGCTTTGCGGAAAGTCCAAAAATA
AGACAAATAAGGCATATAAA

Downstream 100 bases:

>100_bases
TAAAACTTGCTGATTAAGACAGTTTAGGGATACCCTCCTTTTCCCAAAACTGTGTCACTGCTTAACCTTTATTATTGTTA
ATTTATTCTTTTATTATTTC

Product: outer membrane protein

Products: NA

Alternate protein names: Porin ompC; Porin ompk36 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF

Sequences:

>Translated_372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF
>Mature_372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF

Specific function: Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system [H]

COG id: COG3203

COG function: function code M; Outer membrane protein (porin)

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Gram-negative porin family [H]

Homologues:

Organism=Escherichia coli, GI1788544, Length=376, Percent_Identity=62.5, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1787641, Length=362, Percent_Identity=62.1546961325967, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1786436, Length=373, Percent_Identity=55.4959785522788, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1787160, Length=380, Percent_Identity=51.8421052631579, Blast_Score=350, Evalue=6e-98,

Paralogues:

None

Copy number: 6020 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 19068 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001897
- InterPro:   IPR013793
- InterPro:   IPR001702 [H]

Pfam domain/function: PF00267 Porin_1 [H]

EC number: NA

Molecular weight: Translated: 40776; Mature: 40776

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00576 GRAM_NEG_PORIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRM
CCEEEEHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEE
GIKGETQITDQLTGFGQWEYQVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRN
CCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCHHHEEEECCCCCCCCCC
YGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYRNNDFFGLVDGLNIALQYQGK
CEEEEECCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCEEEEEECCEEEEEECCC
NDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
CCCCCCCCCCCCCCCHHEEEEECCCCCCCCEEEECCCCEEECCEECCCHHHHHHHHHHCC
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNG
CCCCCCCEECCCEEECCCEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LRPSLAFLQSRANDVDGLGSFDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNT
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCEEEEEEEEEEEECCCCCCCCC
DNTVALGLVYEF
CCEEEEEEEEEC
>Mature Secondary Structure
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRM
CCEEEEHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEE
GIKGETQITDQLTGFGQWEYQVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRN
CCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCHHHEEEECCCCCCCCCC
YGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYRNNDFFGLVDGLNIALQYQGK
CEEEEECCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCEEEEEECCEEEEEECCC
NDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
CCCCCCCCCCCCCCCHHEEEEECCCCCCCCEEEECCCCEEECCEECCCHHHHHHHHHHCC
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNG
CCCCCCCEECCCEEECCCEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LRPSLAFLQSRANDVDGLGSFDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNT
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCEEEEEEEEEEEECCCCCCCCC
DNTVALGLVYEF
CCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7868262; 10196126 [H]