Click here to switch to the map view.

The map label for this gene is prpR

Identifier: 16763747

GI number: 16763747

Start: 416087

End: 417712

Strand: Reverse

Name: prpR

Synonym: STM0367

Alternate gene names: 16763747

Gene position: 417712-416087 (Counterclockwise)

Preceding gene: 16763752

Following gene: 16763745

Centisome position: 8.6

GC content: 55.72

Gene sequence:

>1626_bases
ATGACGACTGCCCACAGCGCTCCGCGCGATAATAGCGATAAACCGGTGATCTGGACGGTCTCCGTAACGCGTCTGTTCGA
ACTGTTTCGGGATATCAGCCTGGAATTCGATCATCTGGCGACCATCACGCCTATTCAACTCGGCTTTGAAAAGGCGGTGA
CCTACATTCGCAAAAAACTGGCGACCGAGCGCTGCGACGCGATTATCGCGGCGGGTTCGAATGGGGCCTATTTAAAAAGC
CGCCTGTCAATACCGGTGATCCTCATCAAGCCCAGCGGATTCGATGTATTACAGGCGCTGGCGAAAGCGGGAAAGCTCAC
CTCGTCTATCGGTATCGTGACCTATCAGGAGACCATTCCGGCTTTACTTGCCTTTCAGAAAACGTTTCACCTCCGTCTTG
AACAGCGAAGCTATGTCACCGAAGAGGACGCGCGCGGGCAAATTAACGAACTTAAGGCCAACGGTATTGAGGCCGTCGTC
GGCGCGGGATTAATTACCGATCTGGCGGAAGAGGCAGGAATGACCGCCATCTTTATTTATTCCGCGGCGACCGTTCGTCA
GGCTTTTCATGATGCGCTGGATATGACCCGTCTGACACGGCGCCAGCGCGTGGATTACCCATCCGGCAAGGGATTACAAA
CCCGGTATGAACTGGGCGATATACGCGGCCAGTCGCCGCAAATGGAGCAGCTCCGCCAGACGATTACGCTCTATGCCCGC
TCCCGTGCGGCAGTGCTGATTCAGGGGGAAACAGGGACCGGAAAAGAGCTGGCGGCGCAGGCGATTCACCAGACGTTCTT
TCACCGCCAGCCTCACCGTCAGAATAAGCCATCCCCTCCCTTTGTCGCCGTCAATTGCGGCGCGATTACCGAGTCGTTGC
TGGAAGCGGAACTGTTTGGTTATGAAGAGGGCGCGTTTACCGGTTCACGACGAGGAGGCCGGGCGGGGCTGTTTGAAATC
GCACACGGCGGCACGCTGTTTCTGGATGAAATCGGCGAAATGCCCTTGCCGTTACAAACCCGACTTTTGCGCGTACTGGA
GGAAAAAGCCGTCACTCGCGTCGGCGGACACCAGCCGATCCCGGTGGATGTCCGGGTGATCAGCGCTACGCATTGCGATC
TGGATCGGGAGATAATGCAAGGACGTTTTCGCCCCGATCTCTTTTATCGCCTGAGTATTCTGCGTCTGACGCTTCCTCCT
TTGCGCGAGCGGCAGGCTGATATTTTGCCGCTGGCGGAAAGCTTTTTAAAACAGTCGCTGGCGGCGATGGAAATTCCGTT
TACCGAATCGATACGTCATGGATTGACACAGTGTCAGCCGCTTTTGCTGGCCTGGCGCTGGCCCGGTAATATTCGCGAAC
TGCGTAATATGATGGAGCGCCTGGCGCTTTTTTTAAGCGTCGATCCCGCGCCAACGCTGGACAGGCAATTTATGCGGCAG
TTATTACCTGAGCTTATGGTGAACACAGCAGAACTGACGCCTTCAACCGTGGATGCGAACGCGTTACAGGATGTACTGGC
GCGCTTTAAGGGCGATAAGACCGCCGCGGCGCGTTATCTGGGGATTAGCCGCACCACTCTGTGGCGTCGTTTAAAAGCTG
GTGCCAAAGACCAGTCGGATAATTAA

Upstream 100 bases:

>100_bases
GTCAGCTAACGTTTCATGAAACGAATCACCCTGTTTCATTGCAACATTTATGAAACACGTTTAAAACAAAAAATCGCCCC
TTAAAGATGAATCTACTGCG

Downstream 100 bases:

>100_bases
GACAAATGACAGCGTCCTGAATGCCTGATGGCGCTACGTTTACTGCAGGCCGTCATCCGGCAAAACGGATGCCGGTTGCC
AGGAATAAATATACCCGCCG

Product: prp operon regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSDN

Sequences:

>Translated_541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSDN
>Mature_540_residues
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKSR
LSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVG
AGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYARS
RAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEIA
HGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPL
RERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQL
LPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSDN

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain

Homologues:

Organism=Escherichia coli, GI1786524, Length=532, Percent_Identity=79.5112781954887, Blast_Score=843, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=350, Percent_Identity=41.7142857142857, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI87082117, Length=354, Percent_Identity=44.0677966101695, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790437, Length=316, Percent_Identity=43.3544303797468, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788905, Length=326, Percent_Identity=42.638036809816, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI1790299, Length=346, Percent_Identity=40.1734104046243, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789233, Length=331, Percent_Identity=41.0876132930514, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87082152, Length=244, Percent_Identity=46.7213114754098, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=40.2332361516035, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI87081872, Length=245, Percent_Identity=42.4489795918367, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=32.8267477203647, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=31.6614420062696, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1789828, Length=283, Percent_Identity=34.6289752650177, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRPR_SALTY (P74839)

Other databases:

- EMBL:   U51879
- EMBL:   AE006468
- RefSeq:   NP_459362.1
- ProteinModelPortal:   P74839
- GeneID:   1251886
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM0367
- NMPDR:   fig|99287.1.peg.353
- HOGENOM:   HBG740884
- OMA:   LEEDMQQ
- ProtClustDB:   PRK15424
- BioCyc:   STYP99287:STM0367-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524
- SMART:   SM00382
- TIGRFAMs:   TIGR02329

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 60339; Mature: 60208

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00675 SIGMA54_INTERACT_1; PS00676 SIGMA54_INTERACT_2; PS00688 SIGMA54_INTERACT_3; PS50045 SIGMA54_INTERACT_4; PS00134 TRYPSIN_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
ALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHEEHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPI
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSD
HHHHHHHCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure 
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
ALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHEEHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPI
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSD
HHHHHHHCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 11677609