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The map label for this gene is serC [H]

Identifier: 218928537

GI number: 218928537

Start: 1568497

End: 1569582

Strand: Direct

Name: serC [H]

Synonym: YPO1389

Alternate gene names: 218928537

Gene position: 1568497-1569582 (Clockwise)

Preceding gene: 218928536

Following gene: 218928538

Centisome position: 33.7

GC content: 47.42

Gene sequence:

>1086_bases
ATGACACAGGTTTATAATTTTAGCGCTGGTCCAGCAATGTTACCGGTCGAAGTATTACGTCGTGCAGAACAAGAATTACG
TAACTGGCATGGTTTGGGAACGTCGGTGATGGAAATTAGTCACCGCAGTAAAGAATTTATGCAGGTTGCTGAAGAGTCGG
AGAAAGATCTGCGTGACCTGTTGCAGATACCGGCTAATTATAAAGTGTTATTTTGCCATGGTGGTGCCCGAGCACAGTTT
GCTGCGGTGCCATTGAACTTGCTTGGTGACCGCAACAGCGCTGACTATATCGATGGTGGCTATTGGGCGCACAGTGCGAT
TAAAGAAGCACAAAAATACTGCACTCCTAATGTTATTGATGTCACCACCCATGACAATGGCTTAACAGGTATTCAGCCAA
TGAAGCAATGGAAGTTGAGCGATAATGCGGCCTATGTGCACTATTGCCCAAATGAAACCATTGACGGCGTTGCGATTAAT
GAACAGCCTGATTTCGGCAATAAAGTTGTTGTTGCCGATTACTCCTCATCCATTCTTTCCCGTCCTATCGATATTAGCCG
TTATGGTGTGATCTATGCTGGCGCACAGAAGAACATTGGCCCAGCGGGCTTGACACTGGTTATCGTGCGTGAAGATTTAC
TTGGGAAAGCCCACACGGCGTTGCCGTCGATCCTGGACTACAAGGTATTGGCAGATAACGATTCGATGTTCAATACACCG
CCAACGTTCGCTTGGTATCTTTCTGGCCTGGTATTTAAATGGCTGAAAGAGCAGGGTGGTTTGGGCGAAATGGAAAAGCG
CAATCAGGCGAAAGCTGAACTATTGTACGGTGCCATCGACCGCACAGGCTTCTATCGCAATCAGGTTGCTATTACTAACC
GCTCTTGGATGAATGTGCCGTTCCAAATGGCAGATGCTTCATTAGATAAACTGTTCTTGAGTGAAGCTGAAGCACAAGGT
CTGCAGGCCTTAAAAGGCCACCGTGTTGCCGGGGGCATGCGGGCTTCTATCTATAACGCTATGCCAATTGAAGGCGTAAA
AGCCTTAACCGACTTTATGGCTGATTTTGAACGCCGCCATGGCTGA

Upstream 100 bases:

>100_bases
AATTATTTTGGGTATAACCGTTGCAGCAGGCCGACTCGAATGATAAAACCGGGGTACGGGTTATAACGATGGCAATCTCA
GTAGAGTGTGGTGAGGGGAA

Downstream 100 bases:

>100_bases
TTTTTCTGGAGCGGGTACTCATCCGCTCCGGATCGATGGGCCTCTTGCAACAATGAGTTCGTGTGTAATAACGCGTAAAT
TCGTAATAACACGTTAATTT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDLLQIPANYKVLFCHGGARAQF
AAVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVIDVTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAIN
EQPDFGNKVVVADYSSSILSRPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTP
PTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVPFQMADASLDKLFLSEAEAQG
LQALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRHG

Sequences:

>Translated_361_residues
MTQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDLLQIPANYKVLFCHGGARAQF
AAVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVIDVTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAIN
EQPDFGNKVVVADYSSSILSRPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTP
PTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVPFQMADASLDKLFLSEAEAQG
LQALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRHG
>Mature_360_residues
TQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDLLQIPANYKVLFCHGGARAQFA
AVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVIDVTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAINE
QPDFGNKVVVADYSSSILSRPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTPP
TFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVPFQMADASLDKLFLSEAEAQGL
QALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=46.8493150684932, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI10863955, Length=361, Percent_Identity=42.1052631578947, Blast_Score=285, Evalue=4e-77,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=75.9668508287293, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=42.9362880886427, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=39.2207792207792, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=48.4848484848485, Blast_Score=344, Evalue=4e-95,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 40084; Mature: 39953

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDL
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQIPANYKVLFCHGGARAQFAAVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVID
HHCCCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAINEQPDFGNKVVVADYSSSILS
EEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCHHHHC
RPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTP
CCCCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHCHHHHHHHHHHCEEEEECCCCCCCCC
PTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVP
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
FQMADASLDKLFLSEAEAQGLQALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHC
G
C
>Mature Secondary Structure 
TQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDL
CEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQIPANYKVLFCHGGARAQFAAVPLNLLGDRNSADYIDGGYWAHSAIKEAQKYCTPNVID
HHCCCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAINEQPDFGNKVVVADYSSSILS
EEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCHHHHC
RPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTP
CCCCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHCHHHHHHHHHHCEEEEECCCCCCCCC
PTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAITNRSWMNVP
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
FQMADASLDKLFLSEAEAQGLQALKGHRVAGGMRASIYNAMPIEGVKALTDFMADFERRH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2691337 [H]