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The map label for this gene is xapR [H]

Identifier: 218928333

GI number: 218928333

Start: 1317355

End: 1318248

Strand: Direct

Name: xapR [H]

Synonym: YPO1169

Alternate gene names: 218928333

Gene position: 1317355-1318248 (Clockwise)

Preceding gene: 218928332

Following gene: 218928335

Centisome position: 28.31

GC content: 43.29

Gene sequence:

>894_bases
ATGCAAAAGCTTCTTTTTTCCGGTCGTATCAATTTGAAAATGATCCGCTATTTTTTAGCCGTTTCAGACGAGTTACACTT
CGGAAAAGCCGCCGAACGCCTTCATATCTCTCAGCCGCCGTTGAGCCTGCAAATTAAAGAATTAGAAGATGCATTAGGTT
TCCCTCTCTTTATACGAGACAGCCGTAACGTGGTGTTAACCCTGGCGGGCGAAATGATGAAGGCTGAAATGAAAGATGTA
TTTGATAATATAGAGAATTCATTAAGCCGCGTATCCTATATTGCCCGCCATGAACAAACCCACCTTAATATTGGCATTAT
CGGTTCCGCCCTTTGGCATCAGCTACTAGAGAAATTCAAGCATTATAAGACAGTCAATCCTAAGACCACCTGGTCGTTAC
ACGAGCTGCCACCCAGTAAGCAGTATGAAGCCTTATTAAATAAGAAGCTTGATATTGGGTTCTGGCGATGTGCCGATCTG
GAACAGAATCCGGCGCTGATCTATAGGCGGGTAGAAAAGCAGCGTGTCGCCGTCGCCGTGTCTAATGAGAGCTTATTGGT
GAATAAAAAAATACTCACGCTGAAAGATCTCTCAGGGCAAACGCTCATATTTCTCACCTTTAATCACTCTGGCTACTCTA
AAAATTTATACAATAGTTGTCTTAATGCTGGCTGCACGCCGCAGGCTATTTATCAGTTTGATGAACCTCAGACCCAGTTG
GCTTTTGTGAATAGCAACCTTGGTATCGCCTTAGTTCCTGAAAGTATGCAGGAAATCCCATGGCCTAATATTAAATTTAT
TCCGCTGAAAGAAGATCTTTCTGCCGATCTCTTCGCTGTTTATCACCCTGATAGCGTGACTCCGGCACTAAATAAGTTGC
TTGCGTTATTTTGA

Upstream 100 bases:

>100_bases
AATAAATACATATAATTAAGATTGCGGTTTGATTATCAGACAAGATTATTATTGAAATAATAATTCAGGTTGCTCGCATT
AAAATAATTGGATAGGTGAT

Downstream 100 bases:

>100_bases
GTGTGATTTTTGAATCTGTGGCATTCACTGGCCGGTATTACTTGGCTTTAACTAAAATAGCCATCGCGATAATCACTAAA
ATGGCTCCGCTGGCGATCTC

Product: DNA-binding transcriptional activator XapR

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQKLLFSGRINLKMIRYFLAVSDELHFGKAAERLHISQPPLSLQIKELEDALGFPLFIRDSRNVVLTLAGEMMKAEMKDV
FDNIENSLSRVSYIARHEQTHLNIGIIGSALWHQLLEKFKHYKTVNPKTTWSLHELPPSKQYEALLNKKLDIGFWRCADL
EQNPALIYRRVEKQRVAVAVSNESLLVNKKILTLKDLSGQTLIFLTFNHSGYSKNLYNSCLNAGCTPQAIYQFDEPQTQL
AFVNSNLGIALVPESMQEIPWPNIKFIPLKEDLSADLFAVYHPDSVTPALNKLLALF

Sequences:

>Translated_297_residues
MQKLLFSGRINLKMIRYFLAVSDELHFGKAAERLHISQPPLSLQIKELEDALGFPLFIRDSRNVVLTLAGEMMKAEMKDV
FDNIENSLSRVSYIARHEQTHLNIGIIGSALWHQLLEKFKHYKTVNPKTTWSLHELPPSKQYEALLNKKLDIGFWRCADL
EQNPALIYRRVEKQRVAVAVSNESLLVNKKILTLKDLSGQTLIFLTFNHSGYSKNLYNSCLNAGCTPQAIYQFDEPQTQL
AFVNSNLGIALVPESMQEIPWPNIKFIPLKEDLSADLFAVYHPDSVTPALNKLLALF
>Mature_297_residues
MQKLLFSGRINLKMIRYFLAVSDELHFGKAAERLHISQPPLSLQIKELEDALGFPLFIRDSRNVVLTLAGEMMKAEMKDV
FDNIENSLSRVSYIARHEQTHLNIGIIGSALWHQLLEKFKHYKTVNPKTTWSLHELPPSKQYEALLNKKLDIGFWRCADL
EQNPALIYRRVEKQRVAVAVSNESLLVNKKILTLKDLSGQTLIFLTFNHSGYSKNLYNSCLNAGCTPQAIYQFDEPQTQL
AFVNSNLGIALVPESMQEIPWPNIKFIPLKEDLSADLFAVYHPDSVTPALNKLLALF

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=287, Percent_Identity=38.3275261324042, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1787879, Length=278, Percent_Identity=28.0575539568345, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=27.681660899654, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790399, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI157672245, Length=248, Percent_Identity=25.4032258064516, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=26.4591439688716, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693105, Length=289, Percent_Identity=22.4913494809689, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=23.6, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994962, Length=110, Percent_Identity=32.7272727272727, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87081904, Length=169, Percent_Identity=31.3609467455621, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790208, Length=65, Percent_Identity=44.6153846153846, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789173, Length=116, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33867; Mature: 33867

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLLFSGRINLKMIRYFLAVSDELHFGKAAERLHISQPPLSLQIKELEDALGFPLFIRD
CCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCEEEHHHHHHHHCCCEEEEC
SRNVVLTLAGEMMKAEMKDVFDNIENSLSRVSYIARHEQTHLNIGIIGSALWHQLLEKFK
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHH
HYKTVNPKTTWSLHELPPSKQYEALLNKKLDIGFWRCADLEQNPALIYRRVEKQRVAVAV
HHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCEEEEEE
SNESLLVNKKILTLKDLSGQTLIFLTFNHSGYSKNLYNSCLNAGCTPQAIYQFDEPQTQL
CCCEEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHEECCCCCEEE
AFVNSNLGIALVPESMQEIPWPNIKFIPLKEDLSADLFAVYHPDSVTPALNKLLALF
EEEECCCCEEECCHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure
MQKLLFSGRINLKMIRYFLAVSDELHFGKAAERLHISQPPLSLQIKELEDALGFPLFIRD
CCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCEEEHHHHHHHHCCCEEEEC
SRNVVLTLAGEMMKAEMKDVFDNIENSLSRVSYIARHEQTHLNIGIIGSALWHQLLEKFK
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHH
HYKTVNPKTTWSLHELPPSKQYEALLNKKLDIGFWRCADLEQNPALIYRRVEKQRVAVAV
HHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCEEEEEE
SNESLLVNKKILTLKDLSGQTLIFLTFNHSGYSKNLYNSCLNAGCTPQAIYQFDEPQTQL
CCCEEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHEECCCCCEEE
AFVNSNLGIALVPESMQEIPWPNIKFIPLKEDLSADLFAVYHPDSVTPALNKLLALF
EEEECCCCEEECCHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]