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The map label for this gene is adh [H]

Identifier: 15922941

GI number: 15922941

Start: 2621717

End: 2622709

Strand: Direct

Name: adh [H]

Synonym: ST2605

Alternate gene names: 15922941

Gene position: 2621717-2622709 (Clockwise)

Preceding gene: 15922940

Following gene: 15922942

Centisome position: 97.29

GC content: 36.35

Gene sequence:

>993_bases
GTGAAGGCATTAGTTTTTGATAAAAGCGGAATAGAAAACCTTAAGTATACGGATTATGAAGACCCAAAAATAGGTCCAAA
CGAAGTTCTAATTAGGGTAAGATATGCTGGAGTAAATCCAGTAGATTATTATACTGTAACACGGCTTAATGTAAAACCAC
TTCCTCATATACCGGGTGTAGAGTTTGCTGGAGAAGTTGAAAAAGTAGGTGAAAGAGTAACTAAGGTTAAACCTGGTGAT
AGAGTTACAATCTACGGTAGAATATTTGACGGTACTTGCGATATGTGTATGATTGGTTATGAAACTCTATGTAGAAATGG
TGGAAGGATAGGAGTAGATGCTAATGGTGGCTGGGCTGAATATATTGCAGTTGAGGAAAAGTATGTGTTTAAATTACCTA
GTGAGTTTTCATGGGAGTTAGGAAGTAGTATGACTGTTTCAGCTTTAACTGCTTATCATGCATTAAAAGAGGCTAATTTA
AAGCCTGGAGAGGTTTTAGTAGTTTTTGGAGCATCCGGAAATACTGGAATGTTTGCGGTACAATTAGGTAAGAAATTTGG
TGCTAAAGTTATTGCTGTAAGTAGGAAGAGTTGGTTAAAGGATTTCGGTGCAGATCTAGTTGTTGGATATGATGAAGTTG
AAGAGAAAGTGAAAGAGTTTACTAACGGAAAAATGGCTGATGTTGTAATTGATTCCTTAGGAGGGAAGTTATGGAATAAG
GGATTTTCTGTTGTTGGTGTGAAGGGAAGAATAGTAACTTTTGGGACTCTTTTAGGTGCTGAGGTCAGCTTAAATCTATC
TGAACTTTATTCTAAACACATCTCGATATTGGGAGTTAACAGGGGGAATAGGAAGGATTTCGTTGAACTACTTGAATTAT
GTAAAGATTGTAAAGTAAAAACTCACAAAACTTACAAACTTGAAGAGGGTAAAGAAGCCTTACAAGAATTGTTTAACGAG
AAGAGGGATGGAAGAATTTTCCTCTCAACTTAA

Upstream 100 bases:

>100_bases
AGTCTCACAAGAAACTCCATATCACGAATACAAGGTTATCTGGGTAAAGCGTAGATTACTCTTCAGTTAAACATTTTATT
GTTCGAAATAAAACAAAAGT

Downstream 100 bases:

>100_bases
TAGTTTTTTGAAACCATGTTTATTAACATAAATAAATATATTAATATATGCCAATCTGTCCTTCATGTGAAATTAAATTT
AACAGCTGGTATGATGTTGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKALVFDKSGIENLKYTDYEDPKIGPNEVLIRVRYAGVNPVDYYTVTRLNVKPLPHIPGVEFAGEVEKVGERVTKVKPGD
RVTIYGRIFDGTCDMCMIGYETLCRNGGRIGVDANGGWAEYIAVEEKYVFKLPSEFSWELGSSMTVSALTAYHALKEANL
KPGEVLVVFGASGNTGMFAVQLGKKFGAKVIAVSRKSWLKDFGADLVVGYDEVEEKVKEFTNGKMADVVIDSLGGKLWNK
GFSVVGVKGRIVTFGTLLGAEVSLNLSELYSKHISILGVNRGNRKDFVELLELCKDCKVKTHKTYKLEEGKEALQELFNE
KRDGRIFLST

Sequences:

>Translated_330_residues
MKALVFDKSGIENLKYTDYEDPKIGPNEVLIRVRYAGVNPVDYYTVTRLNVKPLPHIPGVEFAGEVEKVGERVTKVKPGD
RVTIYGRIFDGTCDMCMIGYETLCRNGGRIGVDANGGWAEYIAVEEKYVFKLPSEFSWELGSSMTVSALTAYHALKEANL
KPGEVLVVFGASGNTGMFAVQLGKKFGAKVIAVSRKSWLKDFGADLVVGYDEVEEKVKEFTNGKMADVVIDSLGGKLWNK
GFSVVGVKGRIVTFGTLLGAEVSLNLSELYSKHISILGVNRGNRKDFVELLELCKDCKVKTHKTYKLEEGKEALQELFNE
KRDGRIFLST
>Mature_330_residues
MKALVFDKSGIENLKYTDYEDPKIGPNEVLIRVRYAGVNPVDYYTVTRLNVKPLPHIPGVEFAGEVEKVGERVTKVKPGD
RVTIYGRIFDGTCDMCMIGYETLCRNGGRIGVDANGGWAEYIAVEEKYVFKLPSEFSWELGSSMTVSALTAYHALKEANL
KPGEVLVVFGASGNTGMFAVQLGKKFGAKVIAVSRKSWLKDFGADLVVGYDEVEEKVKEFTNGKMADVVIDSLGGKLWNK
GFSVVGVKGRIVTFGTLLGAEVSLNLSELYSKHISILGVNRGNRKDFVELLELCKDCKVKTHKTYKLEEGKEALQELFNE
KRDGRIFLST

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=292, Percent_Identity=30.8219178082192, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI13236495, Length=292, Percent_Identity=30.8219178082192, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI18379349, Length=338, Percent_Identity=26.3313609467456, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239676, Length=199, Percent_Identity=33.1658291457286, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=27.6073619631902, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI28557745, Length=263, Percent_Identity=30.0380228136882, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI47519420, Length=274, Percent_Identity=29.9270072992701, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI24308257, Length=365, Percent_Identity=24.1095890410959, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501933, Length=231, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=27.8787878787879, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=27.8443113772455, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790485, Length=345, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790045, Length=198, Percent_Identity=31.3131313131313, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788407, Length=210, Percent_Identity=29.5238095238095, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082125, Length=234, Percent_Identity=29.0598290598291, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=23.9864864864865, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786518, Length=309, Percent_Identity=26.537216828479, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788075, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=270, Percent_Identity=25.1851851851852, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=331, Percent_Identity=26.2839879154079, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=26.7647058823529, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17507255, Length=339, Percent_Identity=29.2035398230088, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=336, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=327, Percent_Identity=26.2996941896024, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=328, Percent_Identity=23.780487804878, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=27.5147928994083, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=306, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=27.6073619631902, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=293, Percent_Identity=28.6689419795222, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319520, Length=349, Percent_Identity=26.0744985673352, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=339, Percent_Identity=28.3185840707965, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=225, Percent_Identity=29.3333333333333, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=379, Percent_Identity=23.2189973614776, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=280, Percent_Identity=27.5, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=280, Percent_Identity=27.5, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=348, Percent_Identity=25.5747126436782, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=25.3776435045317, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=28.7461773700306, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137530, Length=287, Percent_Identity=27.8745644599303, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36521; Mature: 36521

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVFDKSGIENLKYTDYEDPKIGPNEVLIRVRYAGVNPVDYYTVTRLNVKPLPHIPGV
CCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCC
EFAGEVEKVGERVTKVKPGDRVTIYGRIFDGTCDMCMIGYETLCRNGGRIGVDANGGWAE
CCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHCHHHHHCCCCEEEEECCCCEEE
YIAVEEKYVFKLPSEFSWELGSSMTVSALTAYHALKEANLKPGEVLVVFGASGNTGMFAV
EEEEECEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
QLGKKFGAKVIAVSRKSWLKDFGADLVVGYDEVEEKVKEFTNGKMADVVIDSLGGKLWNK
EECHHCCCEEEEECHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHC
GFSVVGVKGRIVTFGTLLGAEVSLNLSELYSKHISILGVNRGNRKDFVELLELCKDCKVK
CCEEEEECCEEEEEEEEECCEEEECHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCC
THKTYKLEEGKEALQELFNEKRDGRIFLST
CCCEEECHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MKALVFDKSGIENLKYTDYEDPKIGPNEVLIRVRYAGVNPVDYYTVTRLNVKPLPHIPGV
CCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCC
EFAGEVEKVGERVTKVKPGDRVTIYGRIFDGTCDMCMIGYETLCRNGGRIGVDANGGWAE
CCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHCHHHHHCCCCEEEEECCCCEEE
YIAVEEKYVFKLPSEFSWELGSSMTVSALTAYHALKEANLKPGEVLVVFGASGNTGMFAV
EEEEECEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
QLGKKFGAKVIAVSRKSWLKDFGADLVVGYDEVEEKVKEFTNGKMADVVIDSLGGKLWNK
EECHHCCCEEEEECHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHC
GFSVVGVKGRIVTFGTLLGAEVSLNLSELYSKHISILGVNRGNRKDFVELLELCKDCKVK
CCEEEEECCEEEEEEEEECCEEEECHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCC
THKTYKLEEGKEALQELFNEKRDGRIFLST
CCCEEECHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA