| Definition | Sulfolobus tokodaii str. 7 chromosome, complete genome. |
|---|---|
| Accession | NC_003106 |
| Length | 2,694,756 |
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The map label for this gene is ilvI [H]
Identifier: 15922741
GI number: 15922741
Start: 2413273
End: 2414868
Strand: Direct
Name: ilvI [H]
Synonym: ST2410
Alternate gene names: 15922741
Gene position: 2413273-2414868 (Clockwise)
Preceding gene: 15922740
Following gene: 15922750
Centisome position: 89.55
GC content: 36.59
Gene sequence:
>1596_bases ATGGATAGCGGTGCAAGACTCATTTTAAAAAGTCTACAAGATTTAGGTGTAGATAAAATCTTTATGGTATCTGGAACAGA TTATGCAGCATTTATTGAAGAAAAAGTAAGGGATCCTTCATTGCCAGATTTCGTAATAGTACCACATGAAATAACAGCTA CTGCTGCAGCTATAGGCTATTCTCTATCTGGAAAAATAGGGGTTGTTGCAGTTCATACAATTCCGGGTACTACAAATGCT TTAGGAATGATAATTAATGCTTTCACATCTAGAATACCCCTAATAGTTATTGCTGGCAGAAGTCCTTATACTGAAACTGG TAGTCCAGCAAGTAGGAATTTGAGAATACATTGGACTCAAGAGGCTAGGGATCAAGGAGAAATTGTTAGGCAATGGGTTA AATATGATTTTGAAATAAGGAGGACTGAGCAAATACCAGAGGTTATAGCTAGGGCTTATCAGATTGCATTTAGTGAGCCT AAGGGACCAGTATATATTGTGATTCCTAGAGAGGTGAGTATAGAGAAAAGCGAGTACAGAAAAGTTAGAGTTTCAACTTT TGAGCCAGGAATGAAAAGAGAAGATCTAGTAAAGGCTAAGAAAATGATCGAGGAGAGTGAAAGACCAATTATAATTACTT GGAGGGGTGGTAGAAGGAAAGAGTGGTTTGATAGCATAAAAACGTTTGCTGATAAAGTAGGGATACCAGTTTTAAATTAC ATAGGAGAGGTTGTAAATTATTCTGGTGAAATGGGATTAGATAGGATTGATTTATCAACTGTTGATTTAGCTATTGTAGT AGAGGCCGAGGTACCTTATATTCCAAAGAAAACTAAATTTGATGGCAAAATTATAAAGGTTGATGTAGATCCATCTTACT CTTATATCCCATTTTATGGTTTTCCTTGCGACTTGTGTATCCAATCTACCGTTTCAGAATTCTTTGACCAACTAGATGTT AAGGAGAAAAAGGAGTGGAAGGAAAAAGTAAAAGAGCTGAGGCTTCAACAAGAAAAGAAAAAGGAAGAGGAAATAGAACA ATTGAGGAAAAGGAGGTCAATTCATCCTAGATATTTAAGTTACGTTATTGGTAAGGTAATTGGGAAAGATGATGTTATAC TTAATGAGTATCCATTTAATCCTAGATATACAAAGCTTGATTTTGGGCAATACTTCGCTGATCCTTCATTTGGTCATTTA GGCTGGGCTTTAGGTGCTTCTTTCGGTGTCTCGTTAACAAATAGGAAAGTTATTGCTACAGTTGGTGATGGTGCATTTAT TTTTGGAGTGCCAGAGGCATTTTATTATGCAATTTCCACATATGGTGGTAATGTCACGGTAATAATTTATGATAATGGTG GCTGGCTAGCTAGTGCTGAAGCTGTTGAAGAAGTTTTTCCAGAAGGATTGGCAAAGGCAAAGCAGTATTTTCCTGGAGCA GACTTTAAGAGGTATAATATTGGCGAAACCGCTAAGGTTTTTGGTGGGTATTATAGGTTGGTGGAAGATGTTAATGAAGT AGAAGAGAGTGTAAGAGAAGCATACAACTTTAGAGGTATTTCTGTACTGCAAGTTATTGTGGATAGAGTAAGATAA
Upstream 100 bases:
>100_bases TTCTTCCTATTTTCTCCATTATATCTTTGGGCATTAATTTCTATTTTAGGCTTTCTCTCTATTCCATTATATTTATTAAG TATCAAGAGGATTGAAACAA
Downstream 100 bases:
>100_bases AACTATTATTTATTTGCCTCTCTAATTTGTTTTAATTCCCTTTCATATGCTTCTACGATAGAATCGTATGTCAGTATCCC TTTAAATTTTCCTTTTTCTA
Product: acetolactate synthase catalytic subunit
Products: NA
Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]
Number of amino acids: Translated: 531; Mature: 531
Protein sequence:
>531_residues MDSGARLILKSLQDLGVDKIFMVSGTDYAAFIEEKVRDPSLPDFVIVPHEITATAAAIGYSLSGKIGVVAVHTIPGTTNA LGMIINAFTSRIPLIVIAGRSPYTETGSPASRNLRIHWTQEARDQGEIVRQWVKYDFEIRRTEQIPEVIARAYQIAFSEP KGPVYIVIPREVSIEKSEYRKVRVSTFEPGMKREDLVKAKKMIEESERPIIITWRGGRRKEWFDSIKTFADKVGIPVLNY IGEVVNYSGEMGLDRIDLSTVDLAIVVEAEVPYIPKKTKFDGKIIKVDVDPSYSYIPFYGFPCDLCIQSTVSEFFDQLDV KEKKEWKEKVKELRLQQEKKKEEEIEQLRKRRSIHPRYLSYVIGKVIGKDDVILNEYPFNPRYTKLDFGQYFADPSFGHL GWALGASFGVSLTNRKVIATVGDGAFIFGVPEAFYYAISTYGGNVTVIIYDNGGWLASAEAVEEVFPEGLAKAKQYFPGA DFKRYNIGETAKVFGGYYRLVEDVNEVEESVREAYNFRGISVLQVIVDRVR
Sequences:
>Translated_531_residues MDSGARLILKSLQDLGVDKIFMVSGTDYAAFIEEKVRDPSLPDFVIVPHEITATAAAIGYSLSGKIGVVAVHTIPGTTNA LGMIINAFTSRIPLIVIAGRSPYTETGSPASRNLRIHWTQEARDQGEIVRQWVKYDFEIRRTEQIPEVIARAYQIAFSEP KGPVYIVIPREVSIEKSEYRKVRVSTFEPGMKREDLVKAKKMIEESERPIIITWRGGRRKEWFDSIKTFADKVGIPVLNY IGEVVNYSGEMGLDRIDLSTVDLAIVVEAEVPYIPKKTKFDGKIIKVDVDPSYSYIPFYGFPCDLCIQSTVSEFFDQLDV KEKKEWKEKVKELRLQQEKKKEEEIEQLRKRRSIHPRYLSYVIGKVIGKDDVILNEYPFNPRYTKLDFGQYFADPSFGHL GWALGASFGVSLTNRKVIATVGDGAFIFGVPEAFYYAISTYGGNVTVIIYDNGGWLASAEAVEEVFPEGLAKAKQYFPGA DFKRYNIGETAKVFGGYYRLVEDVNEVEESVREAYNFRGISVLQVIVDRVR >Mature_531_residues MDSGARLILKSLQDLGVDKIFMVSGTDYAAFIEEKVRDPSLPDFVIVPHEITATAAAIGYSLSGKIGVVAVHTIPGTTNA LGMIINAFTSRIPLIVIAGRSPYTETGSPASRNLRIHWTQEARDQGEIVRQWVKYDFEIRRTEQIPEVIARAYQIAFSEP KGPVYIVIPREVSIEKSEYRKVRVSTFEPGMKREDLVKAKKMIEESERPIIITWRGGRRKEWFDSIKTFADKVGIPVLNY IGEVVNYSGEMGLDRIDLSTVDLAIVVEAEVPYIPKKTKFDGKIIKVDVDPSYSYIPFYGFPCDLCIQSTVSEFFDQLDV KEKKEWKEKVKELRLQQEKKKEEEIEQLRKRRSIHPRYLSYVIGKVIGKDDVILNEYPFNPRYTKLDFGQYFADPSFGHL GWALGASFGVSLTNRKVIATVGDGAFIFGVPEAFYYAISTYGGNVTVIIYDNGGWLASAEAVEEVFPEGLAKAKQYFPGA DFKRYNIGETAKVFGGYYRLVEDVNEVEESVREAYNFRGISVLQVIVDRVR
Specific function: Valine and isoleucine biosynthesis; first step. [C]
COG id: COG0028
COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family [H]
Homologues:
Organism=Homo sapiens, GI93004078, Length=573, Percent_Identity=22.8621291448517, Blast_Score=77, Evalue=3e-14, Organism=Escherichia coli, GI87081685, Length=484, Percent_Identity=23.3471074380165, Blast_Score=102, Evalue=4e-23, Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=23.4767025089606, Blast_Score=93, Evalue=4e-20, Organism=Escherichia coli, GI1787096, Length=564, Percent_Identity=23.0496453900709, Blast_Score=87, Evalue=2e-18, Organism=Escherichia coli, GI1788716, Length=498, Percent_Identity=24.0963855421687, Blast_Score=76, Evalue=5e-15, Organism=Escherichia coli, GI1786717, Length=432, Percent_Identity=21.9907407407407, Blast_Score=66, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6323755, Length=242, Percent_Identity=26.8595041322314, Blast_Score=71, Evalue=4e-13, Organism=Drosophila melanogaster, GI19922626, Length=563, Percent_Identity=22.5577264653641, Blast_Score=77, Evalue=4e-14,
Paralogues:
None
Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012846 - InterPro: IPR012000 - InterPro: IPR012001 - InterPro: IPR000399 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.6 [H]
Molecular weight: Translated: 60089; Mature: 60089
Theoretical pI: Translated: 6.42; Mature: 6.42
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDSGARLILKSLQDLGVDKIFMVSGTDYAAFIEEKVRDPSLPDFVIVPHEITATAAAIGY CCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHCE SLSGKIGVVAVHTIPGTTNALGMIINAFTSRIPLIVIAGRSPYTETGSPASRNLRIHWTQ EECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECH EARDQGEIVRQWVKYDFEIRRTEQIPEVIARAYQIAFSEPKGPVYIVIPREVSIEKSEYR HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHCC KVRVSTFEPGMKREDLVKAKKMIEESERPIIITWRGGRRKEWFDSIKTFADKVGIPVLNY EEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHH IGEVVNYSGEMGLDRIDLSTVDLAIVVEAEVPYIPKKTKFDGKIIKVDVDPSYSYIPFYG HHHHHCCCCCCCCCEECCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEC FPCDLCIQSTVSEFFDQLDVKEKKEWKEKVKELRLQQEKKKEEEIEQLRKRRSIHPRYLS CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH YVIGKVIGKDDVILNEYPFNPRYTKLDFGQYFADPSFGHLGWALGASFGVSLTNRKVIAT HHHHHHCCCCCEEEECCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHCCCEECCCEEEEE VGDGAFIFGVPEAFYYAISTYGGNVTVIIYDNGGWLASAEAVEEVFPEGLAKAKQYFPGA ECCCEEEEECHHHHHEEHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCC DFKRYNIGETAKVFGGYYRLVEDVNEVEESVREAYNFRGISVLQVIVDRVR CCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC >Mature Secondary Structure MDSGARLILKSLQDLGVDKIFMVSGTDYAAFIEEKVRDPSLPDFVIVPHEITATAAAIGY CCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHCE SLSGKIGVVAVHTIPGTTNALGMIINAFTSRIPLIVIAGRSPYTETGSPASRNLRIHWTQ EECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECH EARDQGEIVRQWVKYDFEIRRTEQIPEVIARAYQIAFSEPKGPVYIVIPREVSIEKSEYR HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHCC KVRVSTFEPGMKREDLVKAKKMIEESERPIIITWRGGRRKEWFDSIKTFADKVGIPVLNY EEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHH IGEVVNYSGEMGLDRIDLSTVDLAIVVEAEVPYIPKKTKFDGKIIKVDVDPSYSYIPFYG HHHHHCCCCCCCCCEECCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEC FPCDLCIQSTVSEFFDQLDVKEKKEWKEKVKELRLQQEKKKEEEIEQLRKRRSIHPRYLS CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH YVIGKVIGKDDVILNEYPFNPRYTKLDFGQYFADPSFGHLGWALGASFGVSLTNRKVIAT HHHHHHCCCCCEEEECCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHCCCEECCCEEEEE VGDGAFIFGVPEAFYYAISTYGGNVTVIIYDNGGWLASAEAVEEVFPEGLAKAKQYFPGA ECCCEEEEECHHHHHEEHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCC DFKRYNIGETAKVFGGYYRLVEDVNEVEESVREAYNFRGISVLQVIVDRVR CCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9688822; 12089438 [H]